University of Pennsylvania ADC

Features in our Latest Issue of the Quarterly include:

Living with Mild Cognitive Impairment, and
the debate among Alzheimer’s researchers
on this condition
APOE’s role in Alzheimer’s risk, and a look
at a study of what people who learned their
APOE status did – and did not –do.
Some thoughts from a caregiver daughter
Findings from a large study on people’s
reactions to cerebrospinal fluid sampling
through lumbar puncture (lp)
News and items from the world of AD research
And, photos of our Research Partner
Thank You Breakfast
and more ...

Read and download a .pdf of this latest issue (16 pages) Volume 5, Issue 4, Fall/Winter 2007

Volume 5 Issue 3, Spring 2007
Features Included:

Brain donation and how progress in Alzheimer's
research depends on it
Fascinating stories of a brain donor and donors-to-be
A look at the CERND study now enrolling at
the PENN Memory Center
Profiles of our staff's personal involvement
in research
A look at Brain Training
and more ...

Read and download a .pdf of this latest issue (16 pages) Volume 5, Issue 3, Spring 2007

Volume 5 Issue 2, Fall 2006

Features Included:

“We Can't Not Try”
Antibodies target brain plaques
Q2 & A with Dr. Steven Arnold
Medical Care Advance Planning: Can We Talk?
and more ...

Read and download a .pdf of this issue (16 pages)

This issue includes an extended coverage insert that addresses the question, “My mother has Alzheimer’s disease. Should I tell her?”

Read and download a .pdf of this insert

Volume 5 Issue 1, Spring 2006

Features Included:

A view from inside Alzheimer's disease
Creativity in dementia
The facts, not fiction, on cerebrospinal fluid sampling
The knowledge YOU made possible
More

Read and download a .pdf of this issue (20 pages)

Volume 4 Issue 3, Fall 2005

Features Included:

"Normal Controls, Extraordinary People"
The Knowledge you made Possible:IMPY
Portrait of a Research Volunteer Extraordinare
Where did Alzheimer's Disease Centers Come From, and Where are they Going: An Interview with Zaven Kachaturian
More

Read and download a .pdf (12 pages) of this issue

Volume 4, Issue 2, Summer 2005

What does "Reduce the Risk of Cognitive Impairment" Really Mean
Want to Maintain Your Brain? Shop!
Women, Drink to Your Health
A Distress-Dementia Link
Christopher Clark, M.D., Receives Unprecendented Grant to Establish a Center of Excellence for Research on Neurodegenerative Diseases
More

Read and download a .pdf (12 pages) of this issue

Volume 3, Issue 3, Fall 2004

Lead Story: Issues Related to Voting by persons With Cognitive Impairment

Primary Focus

Looking at ethical, legal, and practical considerations in assessing an individual's capacity to vote responsibly
An agenda for public policy and education on this issue

Secondary Stories

Information on and ways families can approach Advanced Life Planning
A feature on basics of assisted living and an interview with a facility director
TARP (Temple Association for Retired Persons)
Opportunities for lifelong learning and meaningful cognitive activity
Staff publications and awards; and descriptions of and requests to take part in various ADC research studies

Read and download a .pdf (8 pages) of this issue

Volume 3, Issue 2, Summer 2004

Lead Story: Wanted: One Thousand Dedicated Families - The Load Study

Primary Focus

An overview of the goals of the LOAD study and Penn's role in it
Information on the science of genetic components to dementia
An interview with a LOAD participating family
A "how to" on creating a multi-generation family health and disease "pedigree"

Secondary Stories

Helping children understand Alzheimer's Disease in a loved one
Conferences for families
Staff publications and awards; and descriptions of and requests to take part in various ADC research studies

Read and download a .pdf (8 pages) of this issue

Volume 3, Issue 1, Winter 2004

Lead Story: Memantine: Examining the Choices of Two Caregivers

Primary Focus

Information on Memantine, a look at the clinical and ethical question of when in the course of AD is the benefit of treatment no longer valid
Two extensive interviews conducted by Jason Karlawish with husbands of AD patients in our ADC, one of whom elected treatment with Namenda for his wife, the other, who elected to not start treatment, and their individual reasons why

Secondary Stories

Information on Penn's participation in the .LOAD study
A book/program review of the nationally broadcast "The Forgetting"
Updates on staff activities, publications, and awards
Descriptions of and requests to take part in various ADC research studies

Read and download a .pdf (8 pages) of this issue

Volume 2, Issue 4, Spring 2003

Lead Story: Young Adult Caregivers

Primary Focus

In the form of an exchange of email, two young women, each of whom care for a father diagnosed with AD, share their feelings and awarenesses of those experiences

Secondary Stories

A report on the Greenwall Foundation taskforce on ethical, legal, and social issues related to voting by persons suffering dementia, of which the Education and Information Transfer Core Leader, Jason Karlawish, is a chief panelist
Updates on cooperative efforts with the Alzheimer's Association Delaware Valley Chapter
A review of a book on a daughter's experience with her father's AD
Descriptions of and requests to take part in various ADC research studies

Read and download a .pdf (8 pages) of this issue

Volume 2, Issue 3, Winter 2003

Lead Story: AD and African Americans

Primary Focus

Two articles address particular racial differences in the risk and treatment of Alzheimer's Disease, including findings on antihypertensives preserving cognitive function in African Americans
A look at why AD risk may be higher for African Americans than whites, but without the gene association (APOE e4) more often found in whites

Secondary Stories

Coverage on the role of hip protectors in preventing one of the most common complications of cognitive impairment, hip fracture
An interview on the professional background and philosophies of the Education Core Leader
Descriptions of and requests to take part in various ADC research studies

Read and download a .pdf (8 pages) of this issue

Volume 2, Issue 2, Fall 2002

Lead Story: Mild Cognitive Impairment

Primary Focus

An extensive feature on the diagnostic criteria of MCI
An insight piece on the struggles ADC staff, and MCI-affected individuals may face, with the "labeling" terminology of patient, caregiver, etc., when impairment is so mild as to permit normal general cognitive function and activities of daily living

Secondary Stories

Coverage of a large Dementia Care Conference held by the ADC made available as a webcast
Updates on ongoing Penn research studies
Reviews of books on the scientific understanding of memory and its loss, and on personal involvement with that experience
An interview with the Penn ADC Associate Director and Clinical Core Leader, Dr. Christopher Clark
Professional activities and publications by Penn ADC staff

Read and download a .pdf (8 pages) of this issue

Volume 2, Issue 1, Summer 2002

Lead Story: May We Look At Your Brain? Why Brain donation, especially by non impaired persons, is needed

Primary Focus

A comprehensive explanation of the Penn Brain Tissue Research Program's worldwide collaboration efforts, why donations are so necessary, and addressing common concerns families or potential donors may have related to this procedure

Secondary Stories

A detailed look at the Penn ADC organizational and operational structure, from the National Institutes of Health level down
An interview with the Penn Director of the Center for Neurodegenerative Disease Research, John Trojanowski, M.D., Ph. D., on his experience and interest in the field
A feature on the aspects and benefits of adult day care for persons with cognitive impairment
An interview with the Penn ADC Associate Director and Clinical Core Leader, Dr. Christopher Clark
Information on educational/support programs for caregivers

Read and download a .pdf (8 pages) of this issue

Volume 1, Issue 4, Spring 2002

Lead Story: Staging of Dementia

Primary Focus

An explanation of the process of, and benefits to caregivers and patients from accurately assessing a patient's disease stage, with charts and a glossary to assist caregivers in making that assessment

Secondary Stories

Report on a 2-day "Safe Return" Registration Drive, co-led by our ADC and the Alzheimer's Association, which enrolled 39 participants from our West Philadelphia neighborhoods, boosting area enrollment from 93 to 132, an increase of over 40%
An interview with an ADC Clinical Nurse Specialist on her experience and interest in the field
An explanation of the termination of the AN-1792 clinical trial
Information on the new Alzheimer's Association 24-hour hotline
Descriptions of and invitations to take part in particular ADC research studies

Read and download a .pdf (8 pages) of this issue

Volume 1, Issue 3, Winter 2001

Lead Story: National and Penn-specific AD research efforts

Primary Focus

A comprehensive explanation of the research efforts then and how individuals could take part
Coverage of the Alzheimer's Disease Cooperative Study, why it is important, and its related aspects, including the primary Prevention Instrument Study
An APOE story

Secondary Stories

A background and career philosophy feature on a Clinical Research Coordinator
Information on staff authorship of books and articles
Ways to operationally and financially support the ADC

Read and download a .pdf (6 pages) of this issue

Volume 1, Issue 2, Fall 2001

Lead Story: Clear Thinking on New Alzheimer's Disease Treatments

Primary Focus

An explanation of clinically useful measures of medications, and guidelines for patients and families heartened by news of new "breakthrough" AD medications

Secondary Stories

Cooperation with the regional Alzheimer's Association in sponsoring a support group for early-stage dementia patients, and a concomitant offering for their caregivers
An insight feature on how personal experience shaped the professional background and philosophies of the Education Core Leader
Information on educational offerings available on the ADC's website

Read and download a .pdf (4 pages) of this issue


Our Newsletters FAQs Ten warning signs of Alzheimers Disease The stages of Alzheimers Disease How we diagnose Alzheimers Disease Treating agitation On telling someone she has Alzheimers Disease Driving information Facilitating voting as people age: Implications of cognitive impairment Links to articles of interest Sunrise Magazine's "Ask Jason" column From the community	The Quarterly, the newsletter of the University of Pennsylvania Alzheimer's Disease Center and Penn Memory Center, is published four times yearly. It is sent in electronic and print format to a wide array of readers; from our research participants and their families, to our supporters and contributors, to fellow researchers and interested parties here in the greater Philadelphia region, across our nation and around the world. Subscription Request Features in our Latest Issue of the Quarterly include: Living with Mild Cognitive Impairment, and the debate among Alzheimer’s researchers on this condition APOE’s role in Alzheimer’s risk, and a look at a study of what people who learned their APOE status did – and did not –do. Some thoughts from a caregiver daughter Findings from a large study on people’s reactions to cerebrospinal fluid sampling through lumbar puncture (lp) News and items from the world of AD research And, photos of our Research Partner Thank You Breakfast and more ... Read and download a .pdf of this latest issue (16 pages) Volume 5, Issue 4, Fall/Winter 2007 Volume 5 Issue 3, Spring 2007 Features Included: Brain donation and how progress in Alzheimer's research depends on it Fascinating stories of a brain donor and donors-to-be A look at the CERND study now enrolling at the PENN Memory Center Profiles of our staff's personal involvement in research A look at Brain Training and more ... Read and download a .pdf of this latest issue (16 pages) Volume 5, Issue 3, Spring 2007 Volume 5 Issue 2, Fall 2006 Features Included: “We Can't Not Try” Antibodies target brain plaques Q2 & A with Dr. Steven Arnold Medical Care Advance Planning: Can We Talk? and more ... Read and download a .pdf of this issue (16 pages) This issue includes an extended coverage insert that addresses the question, “My mother has Alzheimer’s disease. Should I tell her?” Read and download a .pdf of this insert Volume 5 Issue 1, Spring 2006 Features Included: A view from inside Alzheimer's disease Creativity in dementia The facts, not fiction, on cerebrospinal fluid sampling The knowledge YOU made possible More Read and download a .pdf of this issue (20 pages) Volume 4 Issue 3, Fall 2005 Features Included: "Normal Controls, Extraordinary People" The Knowledge you made Possible:IMPY Portrait of a Research Volunteer Extraordinare Where did Alzheimer's Disease Centers Come From, and Where are they Going: An Interview with Zaven Kachaturian More Read and download a .pdf (12 pages) of this issue Volume 4, Issue 2, Summer 2005 What does "Reduce the Risk of Cognitive Impairment" Really Mean Want to Maintain Your Brain? Shop! Women, Drink to Your Health A Distress-Dementia Link Christopher Clark, M.D., Receives Unprecendented Grant to Establish a Center of Excellence for Research on Neurodegenerative Diseases More Read and download a .pdf (12 pages) of this issue Volume 3, Issue 3, Fall 2004 Lead Story: Issues Related to Voting by persons With Cognitive Impairment Primary Focus Looking at ethical, legal, and practical considerations in assessing an individual's capacity to vote responsibly An agenda for public policy and education on this issue Secondary Stories Information on and ways families can approach Advanced Life Planning A feature on basics of assisted living and an interview with a facility director TARP (Temple Association for Retired Persons) Opportunities for lifelong learning and meaningful cognitive activity Staff publications and awards; and descriptions of and requests to take part in various ADC research studies Read and download a .pdf (8 pages) of this issue Volume 3, Issue 2, Summer 2004 Lead Story: Wanted: One Thousand Dedicated Families - The Load Study Primary Focus An overview of the goals of the LOAD study and Penn's role in it Information on the science of genetic components to dementia An interview with a LOAD participating family A "how to" on creating a multi-generation family health and disease "pedigree" Secondary Stories Helping children understand Alzheimer's Disease in a loved one Conferences for families Staff publications and awards; and descriptions of and requests to take part in various ADC research studies Read and download a .pdf (8 pages) of this issue Volume 3, Issue 1, Winter 2004 Lead Story: Memantine: Examining the Choices of Two Caregivers Primary Focus Information on Memantine, a look at the clinical and ethical question of when in the course of AD is the benefit of treatment no longer valid Two extensive interviews conducted by Jason Karlawish with husbands of AD patients in our ADC, one of whom elected treatment with Namenda for his wife, the other, who elected to not start treatment, and their individual reasons why Secondary Stories Information on Penn's participation in the .LOAD study A book/program review of the nationally broadcast "The Forgetting" Updates on staff activities, publications, and awards Descriptions of and requests to take part in various ADC research studies Read and download a .pdf (8 pages) of this issue Volume 2, Issue 4, Spring 2003 Lead Story: Young Adult Caregivers Primary Focus In the form of an exchange of email, two young women, each of whom care for a father diagnosed with AD, share their feelings and awarenesses of those experiences Secondary Stories A report on the Greenwall Foundation taskforce on ethical, legal, and social issues related to voting by persons suffering dementia, of which the Education and Information Transfer Core Leader, Jason Karlawish, is a chief panelist Updates on cooperative efforts with the Alzheimer's Association Delaware Valley Chapter A review of a book on a daughter's experience with her father's AD Descriptions of and requests to take part in various ADC research studies Read and download a .pdf (8 pages) of this issue Volume 2, Issue 3, Winter 2003 Lead Story: AD and African Americans Primary Focus Two articles address particular racial differences in the risk and treatment of Alzheimer's Disease, including findings on antihypertensives preserving cognitive function in African Americans A look at why AD risk may be higher for African Americans than whites, but without the gene association (APOE e4) more often found in whites Secondary Stories Coverage on the role of hip protectors in preventing one of the most common complications of cognitive impairment, hip fracture An interview on the professional background and philosophies of the Education Core Leader Descriptions of and requests to take part in various ADC research studies Read and download a .pdf (8 pages) of this issue Volume 2, Issue 2, Fall 2002 Lead Story: Mild Cognitive Impairment Primary Focus An extensive feature on the diagnostic criteria of MCI An insight piece on the struggles ADC staff, and MCI-affected individuals may face, with the "labeling" terminology of patient, caregiver, etc., when impairment is so mild as to permit normal general cognitive function and activities of daily living Secondary Stories Coverage of a large Dementia Care Conference held by the ADC made available as a webcast Updates on ongoing Penn research studies Reviews of books on the scientific understanding of memory and its loss, and on personal involvement with that experience An interview with the Penn ADC Associate Director and Clinical Core Leader, Dr. Christopher Clark Professional activities and publications by Penn ADC staff Read and download a .pdf (8 pages) of this issue Volume 2, Issue 1, Summer 2002 Lead Story: May We Look At Your Brain? Why Brain donation, especially by non impaired persons, is needed Primary Focus A comprehensive explanation of the Penn Brain Tissue Research Program's worldwide collaboration efforts, why donations are so necessary, and addressing common concerns families or potential donors may have related to this procedure Secondary Stories A detailed look at the Penn ADC organizational and operational structure, from the National Institutes of Health level down An interview with the Penn Director of the Center for Neurodegenerative Disease Research, John Trojanowski, M.D., Ph. D., on his experience and interest in the field A feature on the aspects and benefits of adult day care for persons with cognitive impairment An interview with the Penn ADC Associate Director and Clinical Core Leader, Dr. Christopher Clark Information on educational/support programs for caregivers Read and download a .pdf (8 pages) of this issue Volume 1, Issue 4, Spring 2002 Lead Story: Staging of Dementia Primary Focus An explanation of the process of, and benefits to caregivers and patients from accurately assessing a patient's disease stage, with charts and a glossary to assist caregivers in making that assessment Secondary Stories Report on a 2-day "Safe Return" Registration Drive, co-led by our ADC and the Alzheimer's Association, which enrolled 39 participants from our West Philadelphia neighborhoods, boosting area enrollment from 93 to 132, an increase of over 40% An interview with an ADC Clinical Nurse Specialist on her experience and interest in the field An explanation of the termination of the AN-1792 clinical trial Information on the new Alzheimer's Association 24-hour hotline Descriptions of and invitations to take part in particular ADC research studies Read and download a .pdf (8 pages) of this issue Volume 1, Issue 3, Winter 2001 Lead Story: National and Penn-specific AD research efforts Primary Focus A comprehensive explanation of the research efforts then and how individuals could take part Coverage of the Alzheimer's Disease Cooperative Study, why it is important, and its related aspects, including the primary Prevention Instrument Study An APOE story Secondary Stories A background and career philosophy feature on a Clinical Research Coordinator Information on staff authorship of books and articles Ways to operationally and financially support the ADC Read and download a .pdf (6 pages) of this issue Volume 1, Issue 2, Fall 2001 Lead Story: Clear Thinking on New Alzheimer's Disease Treatments Primary Focus An explanation of clinically useful measures of medications, and guidelines for patients and families heartened by news of new "breakthrough" AD medications Secondary Stories Cooperation with the regional Alzheimer's Association in sponsoring a support group for early-stage dementia patients, and a concomitant offering for their caregivers An insight feature on how personal experience shaped the professional background and philosophies of the Education Core Leader Information on educational offerings available on the ADC's website Read and download a .pdf (4 pages) of this issue
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