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We are proud to present InSight and InSight-Light, the new newsletters of the Penn Memory Center. As the science and research covered in our newsletter continue to evolve, so does our newsletter itself.

InSight replaces the former “Quarterly.” This new name and design reflect the human interest and features on people and efforts at the Penn Memory Center and beyond, that bring the knowledge we need about Alzheimer’s disease and healthy brain aging ever closer in sight.

InSight-Light is a new, quick-read, “lighter” version of the full-size Penn Memory Center newsletter. It will come to you twice a year between our two regular InSight issues. As with the full-size InSight newsletter, you can choose to receive either a print version by mail or an electronic version via email. InSight-Light will allow us to bring you more wide-reaching, lighter features. You’ll also get concise answers to common questions about Alzheimer’s disease and healthy brain aging, more timely news on activities and offerings at the PMC, and updates from the world of Alzheimer’s disease and healthy brain aging research at large.


Winter/End of Year 2010

Features in our latest issue of InSight include:

  • “Taking Our Research on the Road” – a look at the tremendous interest and participation in our brain-aging research by hundreds of enthusiastic and “resilient” residents at a local retirement living community
  • ”Talking – and more –about MCI:” Two Penn Memory Center research partners with MCI describe their involvement with interview studies and other research related to better understanding this condition
  • Coverage of enhancements to our care and research for Latinos, including the addition of a new bilingual/bicultural physician
  • Updates from the news and journals on a reliable family-performed quick screen for cognitive problems developed by researchers at Washington University in St. Louis; a study from the Mayo Clinic that found MCI earlier and more often in men, and how investigators at University of Pittsburgh found walking may help preserve grey matter
  • A feature on sleep as we age – beware the “PM’s”
  • Thanks to our recent donors, PMC in the media, and PMC events

Read and download a .pdf of this latest issue, Winter/Year End (with clickable links)


Spring/Summer 2010

InSight - Spring/Summer 2010
Features Included:

  • Interviews with two individuals adjusting to living with Mild Cognitive Impairment; one who is open about his condition and another who’s “Keeping her MCI on the QT”
  • Facts on MCI and the increased risk for developing dementia which it represents
  • Updates from the news and journals about Social Security disability for those with an early-onset Alzheimer’s diagnosis; more evidence of a maternal link to AD, and a study suggesting a “purposeful life” may rebuff dementia
  • An explanation of what Aricept, Namenda and other current Alzheimer’s medications do, and don’t do
  • A talk with Penn Memory Center Director Dr. Steven Arnold, on what he learned as a participant in one of our diagnostic/brain aging studies
  • A list of recent donors, open research studies, and more.

Read and download a .pdf of this issue, Spring/Summer 2010



Fall 2009

InSight - Winter/End of Year 2009
Features Included:

  • A family who remains in a partially terminated investigational drug trial because they believe the benefits to all outweigh the risks
  • How enhanced cognitive testing could help us foresee who may be heading toward cognitive problems before symptoms are evident
  • Our actively recruiting clinical trials; how to become a normal control, and the PMC’s newest line of healthy brain-aging research -- a study on how stress affects life-long brain health
  • Featured articles from the medical journals including understanding that advanced dementia is a terminal illness, and how money-management troubles could signal other cognitive problems in elders
  • Updates of PMC honors, awards, activities, and more
  • Grateful recognition of gifts and bequests

Read and download a .pdf of this issue, Winter/End of Year 2009



Fall 2009

InSight Light - Fall 2009
Features Included:

  • A fascinating interview with the man who brought Alzheimer’s disease to the comics –Woody Wilson, author of Rex Morgan, M.D.
  • Alzheimer’s Disease and Dementia—What’s the Difference?
  • Notable Outreach, Achievements, and Honors at the Penn Memory Center
  • Info on clinical trials, and important roles in our research for people with normal cognition
  • How you can win a $2500 Brain Game
  • More


Read and download a .pdf of this issue, Fall 2009



Fall 2009

InSight - Spring/Summer 2009
Features Included:

  • Penn Memory Center families helping Penn scientists discover the genetics of Alzheimer’s disease
  • Brain donation from our Latino cohort
  • A new test that can be used to determine if an individual with Mild Cognitive Impairment (MCI) will convert to AD, developed through contributions from Penn Memory Center research participants
  • One donor’s special effort to go from donuts to dollars for AD research
  • Thought-provoking items from the news and journals, updates on Penn Memory Center activity, recognizing your gifts, and more.

Read and download a .pdf of this issue (20 pages), Spring/Summer 2009



fall 2009/winter 2009Volume 6, Issue 3, Fall 2008/Winter 2009
Features Included:

  • "Why Alzheimer's Research Needs Cognitively Normal People" with brief features on some of our most dedicated normal controls, and an invitation to join us a normal control research partner.
  • Profiles of three new physicians in our PENN Memory Center: Dr. Roy Hamilton, Dr. Steven Huege, and Dr. David Wolk
  • Info on our caregiver skills group led by new PENN Memory Center Psychologist Melissa Gartenberg Livney, PsyD. New sessions start in 2009
  • Info on the show “Alzheimer’s Disease: Facing the Facts,” an arresting and poignant look at the personal and societal impact of AD today, and what we may be facing tomorrow. This one-hour documentary, airing nationally on PBS television affiliates in 2009, has its roots in our Alzheimer’s Disease Center. It will air locally on WHYY-TV, Thursday January 22nd, 2009 at 10:00 pm.
  • and more ...

Read and download a .pdf of this issue (20 pages) Volume 6, Issue 3, Fall 2008/Winter 2009



spring/summer 2008

Volume 6, Issue 1, Spring/Summer 2008
Features Included:

    • A candid and moving look at husband’s struggle with the psychiatric and emotional complications of his wife Alzheimer’s disease
    • NEW Investigational Drugs studies and insight from research participants
    • Transitions: a caregiver daughter must finally place her mother in a nursing facility
    • How you can receive two free educational DVDs from a national project led by the PENN Alzheimer’s Disease Center
    • News and Journal Items of interest
    • Some thoughts from colleagues on the retirement of PENN Memory Center Director Dr. Christopher Clark
  • and more ...

Read and download a .pdf of this issue (16 pages) Volume 6, Issue 1, Spring/Summer 2008


Quarterly

Volume 5, Issue 4, Winter/Fall 2007
Features Included:

  • Living with Mild Cognitive Impairment, and
    the debate among Alzheimer’s researchers
    on this condition
  • APOE’s role in Alzheimer’s risk, and a look
    at a study of what people who learned their
    APOE status did – and did not –do.
  • Some thoughts from a caregiver daughter
  • Findings from a large study on people’s
    reactions to cerebrospinal fluid sampling
    through lumbar puncture (lp)
  • News and items from the world of AD research
  • And, photos of our Research Partner
    Thank You Breakfast
  • and more ...

Read and download a .pdf of this issue (16 pages) Volume 5, Issue 4, Fall/Winter 2007


Volume 5 Issue 3, Spring 2007
Features Included:

  • Brain donation and how progress in Alzheimer's
    research depends on it
  • Fascinating stories of a brain donor and donors-to-be
  • A look at the CERND study now enrolling at
    the PENN Memory Center
  • Profiles of our staff's personal involvement
    in research
  • A look at Brain Training
  • and more ...

Read and download a .pdf of this issue (16 pages) Volume 5, Issue 3, Spring 2007


Volume 5 Issue 2, Fall 2006

Features Included:

  • “We Can't Not Try”
  • Antibodies target brain plaques
  • Q2 & A with Dr. Steven Arnold
  • Medical Care Advance Planning: Can We Talk?
  • and more ...

Read and download a .pdf of this issue (16 pages)

This issue includes an extended coverage insert that addresses the question, “My mother has Alzheimer’s disease. Should I tell her?”

Read and download a .pdf of this insert


Volume 5 Issue 1, Spring 2006

Features Included:

  • A view from inside Alzheimer's disease
  • Creativity in dementia
  • The facts, not fiction, on cerebrospinal fluid sampling
  • The knowledge YOU made possible
  • More
Read and download a .pdf of this issue (20 pages)

Volume 4, Issue 3, Fall 2005


Features Included:

  • "Normal Controls, Extraordinary People"
  • The Knowledge you made Possible:IMPY
  • Portrait of a Research Volunteer Extraordinare
  • Where did Alzheimer's Disease Centers Come From, and Where are they Going: An Interview with Zaven Kachaturian
  • More
Read and download a .pdf (12 pages) of this issue

Volume 4, Issue 2, Summer 2005

  • What does "Reduce the Risk of Cognitive Impairment" Really Mean
  • Want to Maintain Your Brain? Shop!
  • Women, Drink to Your Health
  • A Distress-Dementia Link
  • Christopher Clark, M.D., Receives Unprecendented Grant to Establish a Center of Excellence for Research on Neurodegenerative Diseases
  • More

Read and download a .pdf (12 pages) of this issue


Volume 3, Issue 3, Fall 2004

Lead Story: Issues Related to Voting by persons With Cognitive Impairment

Primary Focus

  • Looking at ethical, legal, and practical considerations in assessing an individual's capacity to vote responsibly
  • An agenda for public policy and education on this issue
Secondary Stories
  • Information on and ways families can approach Advanced Life Planning
  • A feature on basics of assisted living and an interview with a facility director
  • TARP (Temple Association for Retired Persons)
  • Opportunities for lifelong learning and meaningful cognitive activity
  • Staff publications and awards; and descriptions of and requests to take part in various ADC research studies
Read and download a .pdf (8 pages) of this issue


Volume 3, Issue 2, Summer 2004

Lead Story: Wanted: One Thousand Dedicated Families - The Load Study

Primary Focus
  • An overview of the goals of the LOAD study and Penn's role in it
  • Information on the science of genetic components to dementia
  • An interview with a LOAD participating family
  • A "how to" on creating a multi-generation family health and disease "pedigree"
Secondary Stories
  • Helping children understand Alzheimer's Disease in a loved one
  • Conferences for families
  • Staff publications and awards; and descriptions of and requests to take part in various ADC research studies
Read and download a .pdf (8 pages) of this issue


Volume 3, Issue 1, Winter 2004

Lead Story: Memantine: Examining the Choices of Two Caregivers

Primary Focus
  • Information on Memantine, a look at the clinical and ethical question of when in the course of AD is the benefit of treatment no longer valid
  • Two extensive interviews conducted by Jason Karlawish with husbands of AD patients in our ADC, one of whom elected treatment with Namenda for his wife, the other, who elected to not start treatment, and their individual reasons why
Secondary Stories
  • Information on Penn's participation in the .LOAD study
  • A book/program review of the nationally broadcast "The Forgetting"
  • Updates on staff activities, publications, and awards
  • Descriptions of and requests to take part in various ADC research studies
Read and download a .pdf (8 pages) of this issue


Volume 2, Issue 4, Spring 2003

Lead Story: Young Adult Caregivers

Primary Focus
  • In the form of an exchange of email, two young women, each of whom care for a father diagnosed with AD, share their feelings and awarenesses of those experiences
Secondary Stories
  • A report on the Greenwall Foundation taskforce on ethical, legal, and social issues related to voting by persons suffering dementia, of which the Education and Information Transfer Core Leader, Jason Karlawish, is a chief panelist
  • Updates on cooperative efforts with the Alzheimer's Association Delaware Valley Chapter
  • A review of a book on a daughter's experience with her father's AD
  • Descriptions of and requests to take part in various ADC research studies
Read and download a .pdf (8 pages) of this issue


Volume 2, Issue 3, Winter 2003

Lead Story: AD and African Americans

Primary Focus
  • Two articles address particular racial differences in the risk and treatment of Alzheimer's Disease, including findings on antihypertensives preserving cognitive function in African Americans
  • A look at why AD risk may be higher for African Americans than whites, but without the gene association (APOE e4) more often found in whites
Secondary Stories
  • Coverage on the role of hip protectors in preventing one of the most common complications of cognitive impairment, hip fracture
  • An interview on the professional background and philosophies of the Education Core Leader
  • Descriptions of and requests to take part in various ADC research studies
Read and download a .pdf (8 pages) of this issue


Volume 2, Issue 2, Fall 2002

Lead Story: Mild Cognitive Impairment

Primary Focus
  • An extensive feature on the diagnostic criteria of MCI
  • An insight piece on the struggles ADC staff, and MCI-affected individuals may face, with the "labeling" terminology of patient, caregiver, etc., when impairment is so mild as to permit normal general cognitive function and activities of daily living
Secondary Stories
  • Coverage of a large Dementia Care Conference held by the ADC made available as a webcast
  • Updates on ongoing Penn research studies
  • Reviews of books on the scientific understanding of memory and its loss, and on personal involvement with that experience
  • An interview with the Penn ADC Associate Director and Clinical Core Leader, Dr. Christopher Clark
  • Professional activities and publications by Penn ADC staff
Read and download a .pdf (8 pages) of this issue


Volume 2, Issue 1, Summer 2002

Lead Story: May We Look At Your Brain? Why Brain donation, especially by non impaired persons, is needed

Primary Focus
  • A comprehensive explanation of the Penn Brain Tissue Research Program's worldwide collaboration efforts, why donations are so necessary, and addressing common concerns families or potential donors may have related to this procedure
Secondary Stories
  • A detailed look at the Penn ADC organizational and operational structure, from the National Institutes of Health level down
  • An interview with the Penn Director of the Center for Neurodegenerative Disease Research, John Trojanowski, M.D., Ph. D., on his experience and interest in the field
  • A feature on the aspects and benefits of adult day care for persons with cognitive impairment
  • An interview with the Penn ADC Associate Director and Clinical Core Leader, Dr. Christopher Clark
  • Information on educational/support programs for caregivers
Read and download a .pdf (8 pages) of this issue


Volume 1, Issue 4, Spring 2002

Lead Story: Staging of Dementia

Primary Focus
  • An explanation of the process of, and benefits to caregivers and patients from accurately assessing a patient's disease stage, with charts and a glossary to assist caregivers in making that assessment
Secondary Stories
  • Report on a 2-day "Safe Return" Registration Drive, co-led by our ADC and the Alzheimer's Association, which enrolled 39 participants from our West Philadelphia neighborhoods, boosting area enrollment from 93 to 132, an increase of over 40%
  • An interview with an ADC Clinical Nurse Specialist on her experience and interest in the field
  • An explanation of the termination of the AN-1792 clinical trial
  • Information on the new Alzheimer's Association 24-hour hotline
  • Descriptions of and invitations to take part in particular ADC research studies
Read and download a .pdf (8 pages) of this issue


Volume 1, Issue 3, Winter 2001

Lead Story: National and Penn-specific AD research efforts

Primary Focus
  • A comprehensive explanation of the research efforts then and how individuals could take part
  • Coverage of the Alzheimer's Disease Cooperative Study, why it is important, and its related aspects, including the primary Prevention Instrument Study
  • An APOE story
Secondary Stories
  • A background and career philosophy feature on a Clinical Research Coordinator
  • Information on staff authorship of books and articles
  • Ways to operationally and financially support the ADC
Read and download a .pdf (6 pages) of this issue


Volume 1, Issue 2, Fall 2001

Lead Story: Clear Thinking on New Alzheimer's Disease Treatments

Primary Focus
  • An explanation of clinically useful measures of medications, and guidelines for patients and families heartened by news of new "breakthrough" AD medications
Secondary Stories
  • Cooperation with the regional Alzheimer's Association in sponsoring a support group for early-stage dementia patients, and a concomitant offering for their caregivers
  • An insight feature on how personal experience shaped the professional background and philosophies of the Education Core Leader
  • Information on educational offerings available on the ADC's website
Read and download a .pdf (4 pages) of this issue


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