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Breast cancer is the most common cancer among women and is the leading cause of death from disease in women from ages 25-54. Moreover, a woman's probability of developing breast cancer is markedly influenced by the timing of normal developmental events that occur over the course of her life. The Chodosh laboratory uses genetically engineered mouse models to study the genes and mechanisms that cause breast cancer and that regulate normal mammary gland development. Particular areas of interest include: oncogene-dependence; the function of oncogenes and tumor suppressor genes in breast cancer initiation, metastasis and recurrence; the role of stem cells in cancer and the normal development of the mammary gland; the use of genomics and computational approaches to understand genetic programs in mammary development and breast cancer; the mechanisms by which reproductive events such as puberty and pregnancy alter breast cancer risk in humans; and the use of non-invasive imaging approaches such as PET, MRI, and bioluminescence to study tumor biology. These approaches employ a broad array of molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in mammary gland and tumor biology.
Background
After graduating with a B.S. in Molecular Biophysics and Biochemistry from Yale University in 1981, Dr. Chodosh earned his M.D. from Harvard Medical School and his Ph.D. in Biochemistry from M.I.T. in 1989 in the laboratory of Dr. Phillip Sharp. Dr. Chodosh received his clinical training at the Massachusetts General Hospital in Internal Medicine and in Endocrinology, followed by postdoctoral research with Dr. Philip Leder in the Department of Genetics at Harvard Medical School where he studied transgenic animal models of breast cancer. Dr. Chodosh joined the faculty of the University of Pennsylvania in 1994 and joined the faculty of the of the Abramson Family Cancer Research Institute at the University of Pennsylvania in 2002 as an Associate Investigator. Dr. Chodosh is an Associate Professor in the Departments of Cancer Biology, where he serves as Vice Chair, Cell and Developmental Biology, and Medicine in the Division of Endocrinology, Diabetes and Metabolism. Dr. Chodosh serves as Director of one of four Congressionally-Directed Breast Cancer Centers of Excellence and is Principal Investigator of one of the sites of the National Cancer Institute's Mouse Models of Human Cancer Consortiums. Currently, he leads the Breast Cancer Program at the University of Pennsylvania. Dr. Chodosh's laboratory is focused on the use of genetically engineered mouse models to study breast cancer and the normal developmental biology of the mammary gland. He is a past Charles E. Culpeper Foundation Scholar in the Medical Sciences and presently serves on the advisory board for the Harvard Nurses' Health Study.
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