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The laboratory of J. Alan Diehl, Ph.D. focuses on the mechanisms whereby extra-cellular signals are sensed by the cell cycle machine and are then transmitted into regulated cell cycle progression. This information will provide the framework necessary to elucidate how growth regulatory pathways are subverted in neoplasia. One major focus concerns the elucidation of mechanisms whereby growth-signaling pathways regulate the mitogenically responsive D-type cyclins and more specifically how these pathways regulate accumulation of an active, nuclear cyclin D1-dependent kinase. The second area of interest focuses on how a novel stress-induced signaling pathway emanating from the endoplasmic reticulum regulates cell cycle progression and cell survival.
Background
J. Alan Diehl, Ph.D. received his B.S. in Biochemistry at North Carolina State University in 1990 and his Ph.D. in Biochemistry from the University of Missouri in 1995. Alan Diehl then joined Charles J. Sherr's laboratory at St. Jude Children's Hospital where he completed his postdoctoral training. Following postdoctoral training, he joined The Eppley Cancer Institute at the University of Nebraska Medical Center where, as an Assistant Professor, he was selected as a 2000 V Scholar by the Jim Valvano Foundation. |
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