| 1. |
Determine the potential role of menin/histone H3 methylation in regulating beta cell proliferation |
| 2. |
Unravel the potential mutations of oncogenes such as Ras or tumor suppressors such as p53 and pRB in insulinomas from MEN1 tumors |
| 3. |
Investigate how menin menin regulates endocrine and hematopoietic cells in a tissue-specific manner |
| 4. |
Test whether menin and TGF-ß collaboratively regulate cell proliferaton |
| 5. |
Does menin regulate the chromatin domains in a tissue-specific manner? |
| 6. |
Does menin regulate cells in a transcription-independent manner? |
| 7. |
Elucidate how menin regulates cell cycle regulators specifically in insulin-secreting beta cells |
