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Background
Brian Keith received his Ph.D. from The Rockefeller University. He completed postdoctoral training with Dr. Gerald R. Fink at the Whitehead Institute for Biomedical Research, after which he became an Assistant Professor in the departments of Molecular Genetics and Cell Biology, and Medicine at the University of Chicago. Dr. Keith joined the AFCRI in 1999 as Director of Education and is currently an Associate Investigator and Adjunct Associate Professor in the Department of Cancer Biology.
Dr. Keith collaborates with Dr. Celeste Simon to study how cells respond to oxygen deprivation (hypoxia), which occurs naturally as tissue (or tumor) growth outstrips its blood supply. Specifically, we generate mouse models in which genes encoding critical components of the hypoxic response pathway are mutated. These novel genetic tools offer unique insights into the mechanisms by which hypoxia regulates cancer cell function and tumor growth. In addition to research, Dr. Keith coordinates the educational activities of AFCRI faculty at the medical, graduate, and undergraduate level. Most recently, Dr. Keith has developed an undergraduate course on the biological origins of cancer (Cancer Cell Biology - Biol407), which is offered annually through the Department of Biology. |
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