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Background
Bruce Levine is an alumnus of the University of Pennsylvania. He began his scientific career at the Wistar Institute during summers in high school and while an undergraduate at Penn. While there, he learned cell culture in the laboratory of Dr. Vincent Cristofalo. After graduation in 1984, he worked as a technician in the Division of Infectious Diseases at the Children's Hospital of Philadelphia examining immune responses following Varicella (Chicken Pox) vaccination.
Dr. Levine received his Ph. D. in Immunology and Infectious Diseases from the Johns Hopkins University in 1992. He was a post-doctoral fellow with Dr. Carl June at the Naval Medical Research Institute in Bethesda, MD and later an Investigator at NMRI and Research Assistant Professor of Medicine at the Uniformed Services University for the Health Sciences. During this time, he developed a system for large scale efficient culture of lymphocytes that has proved to be the foundation for several current Phase I clinical trials of adoptive immunotherapy for infection or malignancy at the Abramson Cancer Center at the University of Pennsylvania.
He is currently Director of the Clinical Cell and Vaccine Production Facility which activates, inserts potentially therapeutic genes and expands patient immune system cells ex vivo as a way to re-educate the immune system to better fight residual cancer or infection . A second part of the role of the CVPF in supporting new clinical trials is the scale-up and validation of large-scale cell processing procedures for the next generation of cell therapy trials. The third aspect of the CVPF mission is to study immune status from patient samples pre- and post-treatment to delve into the mechanisms of engineered tumor and HIV immunity. Dr. Levine maintains research interests in lymphocyte growth, activation and senescence, and HIV immunity.
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