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TRANSLATIONAL RESEARCH
Bruce L. Levine
Levine Lab | Staff | Publications | Employment | Clinical Cell Production Facility
Selected Publications

Levine, B.L., Humeau, L.M., Boyer, J., MacGregor, R.R., Rebello T., Lu, X., Binder, G.K., Slepushkin, V., Lemiale, F., Mascola, J.R., Bushman, F.D., Dropulic, B., June, C.H. Gene Transfer in Humans Using A Conditionally Replicating Lentiviral Vector . Proceedings of the National Academy of Sciences USA November 2006.

Porter, D.L., Levine, B.L., Bunin, N., Stadtmauer, E.A., Luger, S.M., Goldstein, S., Loren, A., Phillips, J., Nasta, S., Perl, A., Schuster, S., Tsai, D., Sohal, A., Veloso, E., Emerson, S., June, C.H. A Phase I Trial of Donor Lymphocyte Infusions Expanded and Activated Ex-Vivo Via CD3/CD28 Co-Stimulation. Blood 107(4): 1325-1331, February 2006.

Rapoport, A.P., Stadtmauer, E.A., Aqui, N., Badros, A., Cotte, J., Chrisley, L., Veloso, E., Zheng, Z., Westphal, S., Mair, R., Chi, N., Ratterree, B., Pochran, M.F., Natt, S., Hinkle, J., Sickles, C., Sohal, A., Ruehle, K., Lynch, C., Zhang, L., Porter, D.L., Luger, S., Guo, C., Fang, H.B., Blackwelder, W., Hankey, K., Mann, D., Edelman, R., Frasch, C., Levine, B.L., Cross, A., June, C.H. Restoration of Immunity in Lymphopenic Cancer Patients by Vaccination and Adoptive T Cell Transfer. Nature Medicine 11(11): 1230-1237, November 2005.

Rapoport, A.P., Levine, B.L., Badros, A., Meisenberg, B., Ruehl, K., Nandi, A., Rollins, S., Natt, S., Ratterree, B., Westphal, S., Mann, D., June, C. Molecular Remission of CML after Autotransplantation Followed by Adoptive Transfer of Costimulated Autologous T-Cells. Bone Marrow Transplantation Vol. 33: 53-60, 2004 Notes: doi:10.1038/sj.bmt.1704317.

Bernstein, W.B., Cox, J.H., Aronson, N.E., Tracy, L., Schlienger, K., Ratto-Kim, S., Garner, R., Cotte, J., Zheng, Z., Winestone, L., Liebig, C., Galley, L.M., Connors, M., Birx, D.L., Carroll, R.G., Levine, B.L. Immune Reconstitution Following Autologous Transfers of CD3/CD28 Stimulated CD4+ T Cells to HIV-Infected Persons. Clinical Immunology 111: 262-274, 2004.

Laport GG., Levine BL., Stadtmauer EA., Schuster SJ., Luger SM., Grupp S., Bunin N., Strobl FJ., Cotte J., Zheng Z., Gregson B., Rivers P., Vonderheide RH., Liebowitz DN., Porter DL., June CH. Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation. Blood 102(6): 2004-13, Sep 15 2003.

Levine BL, Bernstein WB, Aronson NE, Schlienger K, Cotte J, Perfetto S, Humphries MJ, Ratto-Kim S, Birx DL, Steffens C, Landay A, Carroll RG, June CH.  Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nature Medicine 8(1):47-53, 2002.

Levine, B.L., Cotte, J., Small, C.C., Carroll, R.G., Riley, J.L., Bernstein, W.B., Van Epps, D., Hardwick, R.A., June, C.H. Large scale production of CD4+ T cells from HIV-1 infected donors following CD3/CD28 costimulation . Journal of Hematotherapy 7:437-448, 1998.

Levine BL, Bernstein W.B., Connors, M., Craighead N., Lindsten T., Thompson C.B., June C.H. Effects of CD28 Costimulation on Long Term Proliferation of CD4+ T Cells In the Absence of Exogenous Feeder Cells. Journal of Immunology 159(12):5921-5930, 1997.

Levine, BL, Mosca, JD, Riley, JL, Carroll, RG, Vahey, MT, Jagodzinski, LL, Wagner, KF, Mayers, DL, Burke, DS, Weislow, OS, St. Louis, DC, June, CH. Antiviral Effect From the CD28 Costimulatory Receptor Mediates Ex Vivo CD4+ T Cell Expansion from Patients with HIV Infection. Science 272:1939-1943, 1996.
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