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University of Pennsylvania Alzheimers Disease Center
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ADNI
The Alzheimer's Disease Neuroimaging Initiative


Underway throughout the US and Canada, ADNI is the largest public-private partnership study of its kind ever. The project uses advanced imaging technology, and studies biomarkers (found in proteins, and fluids such as blood, urine, etc.) to attempt to identify Alzheimer's Disease in its earliest stages, and measure the physiological changes that occur with the disease over time.


The Director of our Alzheimer's Disease Center, Dr. John Trojanowski, is the chief investigator of the Biomarkers Core of this project.


We are a participating ADNI site.

Eligibility

  • Persons age 55 to 90, with Alzheimer's Disease or Mild Cognitive Impairment, and normal control participants age 70 to 90, are studied.
  • Younger persons of Latino heritage in any category may also be eligible.

    For more information on this study, contact the study coordinator, Jessica Nunez Lopez, by email jessica.nunez@uphs.upenn.edu, or by phone at 215-662-4379.

    Other information about ADNI is available from many web sources, including the following

    National Institutes of Health Press Release http://www.nih.gov/news/pr/feb2006/nia-09.htm

    The ADNI website http://www.loni.ucla.edu/ADNI/

    ADEAR (Alzheimer's Disease Education & Referral Center) A Service of the National Institute on Aging http://www.alzheimers.org/ADNI/



    Biomarkers

    This aim of this study is to identify, measure, and store specific biomarkers (found in proteins, and fluids such as blood, urine, and cerebrospinal fluid.) to better understand the physiological changes that occur over time in Alzheimer's Disease. Like ADNI, this study also involves advanced imaging technology. Age and other participation criteria may be somewhat broader than for ADNI.

    Eligibility

  • Persons age 60 to 90 with Alzheimer's Disease or Mild Cognitive Impairment, and normal control participants, as young as age 40, are studied

    For more information on this study, contact the senior research coordinator, Jessica Nunez-Lopez, by email jessica.nunez@uphs.upenn.edu, or by phone at 215-662-4379.


    CERND

    Diagnostic studies aim to identify and better understand changes occurring over time in the brain that cause problems with memory and thinking. The tell-tale chemical and physical indicators of these changes are known as “biomarkers.”

    The CERND (Center for Excellence in Research on Neurodegenerative Diseases) Study uses and compares different diagnostic technologies to detect these “biomarkers” of changes in the brain.

    For more information on this study, contact the study coordinator, Marianne Watson, by email marianne.watson@uphs.upenn.edu, or by phone at 215-662-4373.

    Click here to read our CERND brochure.

    Click here to read our CERND brochure in Spanish.

     


    CSF SAMPLING

    Sampling of Cerebrospinal Fluid (CSF) through a process known as lumbar puncture, or spinal tap, is often an important part of Alzheimer's Disease research.

    Learn the facts - not the frightening fiction - about CSF sampling.


    Healthy Brain Monitoring

    The purpose of this study is to learn how to best, and most easily, monitor brain health outside of the clinic. Persons in this study will complete a series of cognitive tests over four years in their home, and be provided follow-up medical care if any changes brain health are suspected. These tests will be done on mail-in forms, the telephone, or a computer. We are we doing this study because we know very little about how best to monitor the cognitive health of individuals from the comfort of their own home.

    Enrollment is now closed.

    For more information on this study, contact the research coordinator, Kristin Harkins, by email kristin.harkins@uphs.upenn.edu or by phone at 215-349-5545.


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