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Member Information
Dean Cruess, PhD
Assistant Professor, Department of Psychology
Office Phone: 215-573-4801
Office Fax: 215-898-7301
Email: dcruess@psych.upenn.edu
Website(s):
Education: PhD 1998, University of Miami
Keywords: Depression, Stress and Stress Management, Psychoneuroimmunology
Research and/or Clinical Interests:
My research examines how psychosocial factors, such as stress and depression, can affect one's physical health and the underlying physiological mechanisms involved in this process.
Summary:
My HIV-related research examines how depression and stress, and also psychological treatment for these conditions, can affect an individual's physical health and the underlying physiological mechanisms involved in this process. I conduct research within the multidisciplinary field of Psychoneuroimmunology (PNI), which examines how stressors, stress responses and distress states relate to immune function by way of neural and endocrine processes. I am particularly interested in the effects of cognitive-behavioral therapy (CBT), stress-reduction strategies, and emotional expression on mood, stress and sex hormones, and immune regulation. Over the past several years, I have studied the effects of a group-based, cognitive-behavioral stress management (CBSM) intervention on the psychological, neuroendocrine and immune function of individuals diagnosed with HIV/AIDS. I am currently engaged in a collaborative project funded by the NIMH examining the effects of depression, and it's treatment, on endocrine and immune function among HIV-seropositive women. I am also developing a pilot study to study the physiological effects of traumatic stress among HIV+ adolescents.
Representative Publications:
Cruess, D.G., Evans, D.L., Repetto, M.J., Gettes, D.R., Douglas , S.D. , Petitto, J.M. Prevalence, diagnosis, and pharmacological treatment of mood disorders in HIV disease. Biological Psychiatry 54: 307-316, 2003."
Cruess, D.G., Antoni, M.H., Gonzalez, J., Fletcher, M.A., Klimas, N., Duran, R., Ironson, G., Schneiderman, N. Sleep disturbance mediates the association between psychological distress and immune status among HIV-positive men and women on combination antiretroviral therapy. Journal of Psychosomatic Research 54: 185-189, 2003."
Cruess, D.G., Petitto, J.M., Leserman, J., Douglas, S.D., Gettes, D.R., Ten Have, T.R., Evans, D.L. Depression and HIV infection: Impact on immune function and disease progression. CNS Spectrums 8: 52-58, 2003."
Repetto, M.J., Evans, D.L., Cruess, D.G., Gettes, D.R., Douglas, M.D., Petitto, J.M. Neuropsychopharmacological treatment of depression and other neuropsychiatric disorders in HIV-infected individuals. CNS Spectrums 8: 59-63, 2003."
Evans, D.L., Ten Have, T., Douglas, S.D., Gettes, D.R., Morrison, M., Chiappini, M.S., Brinker-Spence, P., Job, C., Mercer, D., Wang, Y.L., Cruess, D.G., Dube, B., Dalen, E.A., Brown, T., Bauer, R., Petitto. J.M. Depression in women with HIV-infection is associated with viral load, CD8 T cells and natural killer lymphocytes. American Journal of Psychiatry 159: 1752-1759, 2002."
Antoni, M.H., Cruess, D.G., Klimas, N., Maher, K., Cruess, S.E., Kumar, M., Lutgendorf, S., Ironson, G., Schneiderman, N., Fletcher, M.A. Stress management and immune system reconstitution in symptomatic HIV-infected gay men over time: Effects on transitional naive T-cells (CD4+CD45RA+CD29+). American Journal of Psychiatry 159: 143-145, 2002."
Cruess, D.G., Leserman, J., Petitto, J.M., Golden, R.N., Szuba, M.P., Morrison, M.F., Evans, D.L . Psychosocial-immune relationships in HIV disease . Seminars in Clinical Neuropsychiatry 6: 241-252, 2001."
Antoni, M.H., Cruess, D.G., Cruess, S.E., Lutgendorf, S., Kumar, M., Ironson, G., Klimas, N., Fletcher, M.A., Schneiderman, N. Cognitive behavioral stress management intervention effects on anxiety, 24-hour urinary norepinephrine output, and T-cytotoxic/suppressor cells over time among symptomatic HIV-infected gay men. Journal of Consulting and Clinical Psychology 68: 31-45, 2000."
Cruess, D.G., Antoni, M.H., Schneiderman, N., Ironson, G., McCabe, P., Fernandez, J.B., Cruess, S.E., Klimas, N., Kumar, M. Cognitive-behavioral stress management increases free testosterone and decreases psychological distress in HIV-seropositive men. Health Psychology 19: 12-20, 2000."
Cruess, D.G., Antoni, M.H., Kumar, M., Schneiderman, N. Reductions in salivary cortisol are associated with mood improvement during relaxation training among HIV-seropositive men. Journal of Behavioral Medicine 23: 107-122, 2000."
Cruess, S.E., Antoni, M.H., Cruess, D.G., Fletcher, M.A., Ironson, G., Kumar, M., Hayes, A., Klimas, N., Schneiderman, N. Reductions in Herpes Simplex Virus Type-2 antibody titers after cognitive behavioral stress management and relationships with neuroendocrine function, relaxation skills and social support in HIV-positive men. Psychosomatic Medicine 62: 828-837, 2000."
Antoni, M.H., Cruess, S.E., Cruess, D.G., Kumar, M., Lutgendorf, S., Ironson, G., Dettmer, E., Williams, J., Klimas, N., Fletcher, M.A., Schneiderman, N. Cognitive behavioral stress management reduces distress and 24-hour urinary free cortisol output among symptomatic HIV-infected gay men. Annals of Behavioral Medicine 22: 29-37, 2000."
