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Member Information
John A. Detre, MD
Associate Professor, Departments of Neurology and Radiology
Director, Center for Functional Neuroimaging, University of Pennsylvania
Office Phone: 215-349-8465
Office Fax: 215-614-1927
Email: detre@mail.med.upenn.edu
Website(s): http://ictus.med.upenn.edu/; http://cfn.upenn.edu/
Education:
Keywords: Basic and Clinical Neuroimaging, Cerebral Blood Flow
Research and/or Clinical Interests:
Developing and validating neuroimaging biomarkers of disease progression and therapeutic response in the brain.
Summary:
My research interests include cerebrovascular physiology, physiology of functional activation, cognitive neuroimaging, and clinical applications of functional neuroimaging, particularly in stroke and epilepsy. Current research interests represent an integrated program that ranges from basic investigations to clinical diagnosis and is consolidated around several topics, all of which pertain to neuroimaging in neuropsychiatric disorders of the CNS.
Representative Publications:
Buerk, D.G., B.M. Ances, J.H. Greenberg & J.A. Detre (2003) Temporal dynamics of brain tissue nitric oxide during functional forepaw stimulation in rats. Neuroimage 18, 1-9.
Wang, J., D.C. Alsop, L. Li, J. Listerud, J.B. Gonzalez-At, M.D. Schnall & J.A. Detre (2002) Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla. Magn. Reson. Med. 48, 242-54.
Aguirre, G.K., J.A. Detre & D.C. Alsop (2002) Experimental design and the relative sensitivity of BOLD and perfusion fMRI. Neuroimage 15, 488-500.
Ances, B.M., D.G. Buerk, J.H. Greenberg & J.A. Detre (2001) Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats. Neurosci. Lett. 306, 106-10.
Ances, B.M., D.F. Wilson, J.H. Greenberg & J.A. Detre (2001) Dynamic changes in CBF, O2 tension and calculated CMRO2 during functional activation using oxygen phosphorescence. J. Cereb. Blood Flow Metab. 21, 511-16.
Ances, B.M., E. Zarahn , J.H. Greenberg & J.A. Detre (2000) The coupling of neural activation to blood flow in the somatosensory cortex of rats is time-intensity seperable but not linear. J. Cereb. Blood. Flow Metab. 20, 921-30.
Gonzalez-At, J.B., D.C. Alsop & J.A. Detre (2000) Perfusion and transit time changes during task activation determined with steady-state arterial spin labeling. Magn. Reson. Med. 43, 739-746.
Chalela, J.A., D.C. Alsop, J.B. Gonzalez-Atavalez, J.A. Maldjian, S.E. Kasner & J.A. Detre (2000) Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling. Stroke 31, 680-687.
Ances, B.M., J.H. Greenberg & J.A. Detre (2000) Effects of variations in interstimulus interval on activation flow coupling response and somatosensory evoked potentials with forepaw stimulation in the rat. J. Cereb. Blood Flow Metab. 20, 290-297.
Alsop , D.C. , J.A. Detre & M. Grossman (1999) Assessment of cerebral blood flow in Alzheimer's disease by spin labeling MRI. Ann. Neurol. 47, 93-100.
Ances, B.M, J.H. Greenberg., & J.A. Detre (1999) Laser Doppler imaging of activation-flow coupling in rat somatosensory cortex. Neuroimage 10, 716-723.
Detre, J.A., O.B. Samuels, D.C. Alsop, J.B. Gonzalez-At, S.E. Kasner & E.C. Raps (1999) Noninvasive MRI evaluation of CBF with acetazolamide challenge in patients with cerebrovascular stenosis. JMRI 10, 870-875.
Detre, J.A., B.M. Ances, K. Takahashi, and J.H. Greenberg (1998) Signal averaged laser Doppler measurements of activation-flow coupling in the rat forepaw somatosensory cortex. Brain Res. 726, 921-28.
Alsop , D.C. & J.A. Detre (1998) Multi-slice cerebral blood flow imaging with continuous arterial spin labeling MRI. Radiology 208, 410-416.
Detre, J.A., L. Maccotta, D. King, D.C. Alsop, M. D'Esposito, E. Zarahn , G.K. Aguirre, G. Glosser & J.A. French (1998) Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology 50, 926-32.
Detre, J.A., D.C. Alsop, L.R. Vives, L. Maccotta, J.W. Teener & E.C. Raps (1998) Noninvasive perfusion MRI in cerebrovascular disease. Neurology 50, 633-641.
Bagley, L.J., R.I. Grossman, K.D. Judy, M. Curtis, L.A. Loevner, M. Polansky & J. Detre (1997) Gliomas--Correlation of Magnetic-Susceptibility artifact with histologic grade. Radiology 202, 511-16.
Detre, J.A., D.C. Alsop, G.K. Aguirre, and M.R. Sperling (1996) Coupling of cortical and thalamic ictal activity in human partial epilepsy. Epilepsia, 37, 657-61.
Alsop , D.C. and J.A. Detre (1996) Reduced transit time sensitivity in noninvasivee magnetic resonance imaging of human cerebral blood flow. J. Cereb. Blood Flow Metab., 16, 1236-49.
Aguirre, G.K., J.A. Detre , D.C. Alsop, and M. D'Esposito (1996) The parahippocampus subserves topographical learning in humans. Cerebral Cortex, 6, 824-829.
Alsop, D.C., H. Murai, J.A. Detre, T.K. McIntosh and D.H. Smith (1996) etre, J.A., J.I.Sirven, D.C. Alsop, M.J. O'Connor and J.A. French (1995) Localization and time course of subclinical ictal activity by functional MRI: Correlation with invasive monitoring. Ann. Neurol. 38, 618-624.
D'Esposito, M., J.A. Detre , D.C. Alsop, R.K. Shin, S.W. Atlas, and M. Grossman (1995) The neural basis of the central executive system of working memory. Nature 378, 279-81.
