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Member Information
Dwight L. Evans, MD
Ruth Meltzer Professor and Chairman
Professor of Psychiatry, Medicine and Neuroscience
Chair, Department of Psychiatry
Office Phone: 215-662-2818
Office Fax: 215-662-6911
Email: dlevans@mail.med.upenn.edu
Website(s):
Education: MD 1976, Temple University
Keywords: Depression, Medical Illnesses --concentration on HIV disease
Research and/or Clinical interests:
Determine if antidepressants, conventional and novel, can benefit HIV infected individuals and extend their survival rate
Summary:
Dr. Evans' research examines how stress and depression may affect key parameters of cellular immunity in normal subjects, psychiatric patients and patients with HIV infection. Stress and depressive symptoms, especially when they occur jointly, are associated with decreased cellular immunity. In immunocompromised individuals, such as patients with HIV infection or cancer, stress and depressive symptoms may have clinical implications for the course of the disease. Underlying mechanisms with a specific focus on innate immunity are being studied as well as neuroendocrine and neuropeptide mechanisms.
Representative Publications:
Repetto MJ, Evans, DL, Cruess DG, Gettes DR , Douglas SD, Petitto JM: Neuropsychopharmacologic Treatment of Depression and Other Neuropsychiatric Disorders in HIV-Infected Individuals. CNS Spectrums 8(1):59-63, 2003
Cruess DG, Petitto J, Leserman J, Douglas S, Gettes D, Ten Have T, Evans DL: Depression and HIV Infection: Impact on Immune Function and Disease Progression. CNS Spectrums 8(1):52-58, 2003.
Evans DL, Charney DS: Mood Disorders and Medical Illness: A Major Public Health Problem (Editorial) Biological Psychiatry 54(3):177-180, 2003.
Cruess DG, Evans DL, Repetto MJ, Gettes D, Douglas SD, Petitto JM: Prevalence, diagnosis and pharmacological treatment of mood disorders in HIV disease Biological Psychiatry 54(3):307-316, 2003.
Petitto JM, Cruess DG, Evans DL: Clinical Neuroimmunology: Understanding the Development and Pathogenesis of Neuropsychiatric and Psychsomatic Illnesses. In: The Neurobiology of Mental Illness , DS Charney, EJ Nestler, RB Innis (Eds.) Oxford University Press, New York, NY. (In press).
Ho WZ, Evans DL, Douglas SD: Substance P and Human Immunodeficiency Virus Infection: Psychoneuroimmunology. CNS Spectrums 7(12): 867-874, 2002.
Evans DL, Ten Have T, Douglas SD, Gettes DR, Morrison M, Chiappini MS, Brinker-Spence P, Job C, Mercer D, Wang YL, Cruess D, Dube B, Dalen EA, Brown T, Bauer R, Petitto JM: Association of Depression with Viral Load, CD8 T Lymphocytes, and Natural Killer Cells in Women with HIV Infection. American Journal of Psychiatry 159:10:1752-1759, 2002.
Barroso J, Preisser JS, Leserman J, Gaynes BN, Golden RN, Evans DL: Predicting Fatigue and Depression in HIV Positive Gay Men. Psychosomatics 43(4): 317-325, 2002.
Morrison M, Petitto J, Ten Have T, Gettes D, Chiappini M, Weber M, Brinker-Spence P, Bauer R, Douglas S, Evans DL: Prevalence of Depressive and Anxiety Disorders in Women with HIV Infection. American Journal of Psychiatry 159:5:789-796, 2002.
Leserman J, Petitto JM, Gu H, Gaynes BN, Barroso J, Golden R, Perkins DO, Folds JD, Evans DE: Progression to AIDS, a Clinical AIDS Condition, and Mortality: Psychosocial and Psychological Predictors. Psychological Medicine 32: 1059-1073, 2002.
Evans DL, Mason K, Bauer R, Leserman J, Petitto J: Neuropsychiatric Manifestations of HIV-1 Infection and AIDS, In: Neuropsychopharmacology: The Fifth Generation of Progress D Charney, J Coyle, K Davis, C Nemeroff (Eds.), Raven Press, NY 2002.
Gumnick JF, Evans DL, Miller AH: Nervous, Endocrine and Immune System Interactions in Psychiatry. In: Textbok of Neuropsychiatry and Clinical Neurosciences , SC Yudofsky and RE Hales (Eds.) American Psychiatric Press, Inc., Washington , DC . 2002
Douglas SP, Gettes DR, Ho WZ, Cnaan A, Zhao H, Evans DL: Elevated Substance P Levels in HIV-Infected Men. AIDS 15:2043-2045, 2001.
