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Member Information
David S. Metzger, PhD
Associate Professor, Department of Psychiatry
Office Phone: 215-746-7346
Office Fax:
Email: dsm@mail.med.upenn.edu
Website(s): http://www.uphs.upenn.edu/rap/index.htm
Education: PdD 1987, Rutgers University
Keywords: Prevention, Injection and non-injection drug use, Drug Treatment, Vaginal Microbicides, HIV Vaccines, Hepatitis C, Immune function
Research and/or Clinical Interests:
Developing and evaluating structural, behavioral and biomedical HIV prevention interventions among drug and alcohol using populations.
Summary:
Our research group is focused on evaluating structural, behavioral and biomedical prevention interventions for drug using populations at highest risk of HIV infection. With regard to structural interventions, we have a particular interest in evaluating the impact of drug treatment on HIV risk and infection. Behavioral interventions tested by our group include group level interventions for drug using women and social network interventions for injection drug users. Our group has also conducted Phase I trials of vaginal microbicides and has participated in a Phase II trial of HIV vaccines. In collaboration with Drs. Steven Douglas and Wenzhe Ho of the Children's Hospital of Philadelphia , we are also exploring the impact of continued drug and alcohol use on immune function among HIV infected individuals.
Internationally, our group is involved in studies among drug users in St. Petersburg , Russia , Rio de Janiero and Porto Alegre , Brazil . As a site of the HIV Prevention Trials Network (HPTN), we are also involved in the development and implementation of protocols for studies targeting drug using populations in China , Thailand , and St. Petersburg . The HPTN (www.HPTN.org) is a network of domestic and international research sites established to test prevention interventions using HIV infection as the primary outcome measure.
Our research interests also include the development of methods necessary to recruit and retain high risk drug using populations, HIV risk assessments, sexual partnerships of injection drug users, and geographic analyses of risk behavior.
Representative Publications:
Yang, J.H., Lai, J.P., Douglas, S.D., Metzger, D., Zhu, X.H., and Ho, W.Z. Real-time PCR for quantification of hepatitis C Virus RNA. J Virologic Meth. 102:119-128, 2002.
Pechansky, F., Hirakata , V., and Metzger, D. Adaptation and validation of a questionnaire about risk behaviors for AIDS among drug users. Brazilian Journal of Psychiatry. 24: 130-136, 2002.
Porter, J., Metzger, D.S., and Scotti, R. Awareness of drug treatment and other services among needle exchange participants. Drug Use and Misuse. 2002.
Wang, X., Douglas , S.D. , Metzger, D.S., Guo, C-J.,. Li, Y., O'Brien C.P., Song, L., Davis-Vogal, A., and Ho, W-Z.: Alcohol potentiates HIV-1 infection of human blood mononuclear phagocytes. Alcohol. Clin. Exp. Res. 26:1880-1886, 2002.
Pechansky, F., von Diemen, L., Kessler, F., Hirakata, V., Metzger, D., Woody, G.E. Preliminary estimates of HIV prevalence and incidence among cocaine abusers of Porto Alegre, Brazil. J. Urban Health, 80:115-126, 2003.
Coletti, A., Heagerty, P., Sheon, A., Gross, M., Koblin, B., Metzger, D., Seage, G. Randomized, controlled evaluation of a prototype informed consent process for HIV vaccine trials. Journal of Acquired Immune Deficiency Syndromes, 32: 161-169, 2003.
Messiah A, Navaline H, Davis-Vogel A, Tobin-Fiore D, Metzger D. Sociodemographic and behavioral characteristics associated with timeliness and retention in a six-month follow-up study of high-risk injection drug users. American Journal of Epidemiology, 157: 930-939, 2003.
Needle, R.H., Trotter,R.T. II, Singer, M., Bates, C., Page, J.B., Metzger,D., Marcelin, L. Rapid Assessment of the HIV/AIDS crisis in racial and ethnic minority communities: an approach for timely community interventions. Am J Pub Health, 93: 970-979, 2003.
Zhang, T., Li, Y., Lai, J-P., Douglas , S.D. , Metzger, D.S., O'Brien C.P., and Ho, W-Z.: Alcohol potentiates hepatitis C virus (HCV) replicon expression. Hepatology. 38(1), 57-65, 2003.
Metzger DS, Navaline HA, Woody GE. Drug abuse treatment as AIDS prevention. Public Health Reports, In Press.
Cornish JW, Metzger DS, Woody GE, Wilson D, McLellan AT, Vandergrift B, O'Brien CP. Naltrexone pharmacotherapy for opoid dependent federal probationers. Journal of Substance Abuse Treatment. 1997:14 (6):529-534.
Fureman I, Meyers K, Metzger D, McLellan AT, Woody GE. Evaluation of a video supplement to informed consent: injection drug users and preventive HIV vaccine efficacy trials. AIDS Education and Prevention. 1997.
