Agenda

Thursday, October 18, 2007

1:00 - 1:15 p.m.

WELCOME - Jim Hoxie and Andrew Lackner

NEUROPATHOGENESIS: Francisco González-Scarano, Session Chair

1:15 - 1:45 p.m.

Andrew Lackner, DVM, Ph.D.
Professor of Microbiology/Immunology/Pathology
Director, Tulane National Primate Research Center
Francisco González-Scarano, M.D.
Professor/Chair of Neurology, University of Pennsylvania
"Host and Viral Factors in the Neuropathogenesis of AIDS"

1:45 - 2:15 p.m.

Janice Clements, Ph.D.
Director, Department of Molecular & Comparative Pathobiology, Johns Hopkins University
"Innate Immune Response in the CNS: Induction of HIV/SIV Transcriptional Latency in Macrophages"

2:15 - 2:45 p.m.

Dana Gabuzda, M.D.
Professor of Neurology, Harvard Medical School
Cancer Immunology and AIDS, Dana Farber Cancer Institute
"Viral Variants and Monocyte Activation in HIV/SIV Pathogenesis"

2:45 - 3:00 p.m.

BREAK

IMMUNOPATHOGENESIS: Steven D. Douglas, Session Chair

3:05 - 3:35 p.m.

Danny Douek, Ph.D.
Chief, Human Immunology Section, Vaccine Research Center , NIH
"HIV Disease Progression: Immune Activation, Microbes and a Leaky Gut"

3:35 - 4:05 p.m.

Ron Veazey, DVM, Ph.D.
Professor of Pathology, Tulane National Primate Research Center
"Mechanisms of CD4 T cell depletion in SIV infection"

4:05 - 4:35 p.m.

Cristian Apetrei, M.D., Ph.D.
Tulane National Primate Research Center
"Acute Intestinal CD4+ T-Cell Depletion Is Not Predictive of SIV Virulence"

4:35 - 5:05 p.m.

Ashley Haase, M.D.
Professor of Medicine, Professor/Head of Microbiology, University of Minnesota
"The Impact of Apoptosis on Innate and Adaptive Immunity in the Gut in Acute SIV Infection"

Friday, October 19, 2007

8:00 - 8:30 a.m.

Continental Breakfast

8:30 - 8:40 a.m.

WELCOME - Jim Hoxie and Andrew Lackner

NATURAL HOSTS: Guido Silvestri, Session Chair

8:40 - 9:10 a.m.

Guido Silvestri, M.D.
Associate Professor of Pathology and Lab Medicine, University of Pennsylvania
"Natural SIV Infection: Implications for AIDS Pathogenesis"

9:10 - 9:40 a.m.

Ivona Pandrea, M.D., Ph.D.
Associate Professor of Comparative Pathology,
Tulane National Primate Research Center
"Pathogenesis of SIVagm in African Green Monkeys"

9:40 - 10:00 a.m.

BREAK

PREVENTION / Microbicides: Ron Veazey, Session Chair

10:00 - 10:30 a.m.

John Moore, Ph.D.
Professor of Microbiology and Immunology, Cornell University
"Entry Inhibitor-based Microbicides to Prevent HIV-1 Sexual Transmission"

10:30 - 11:00 a.m.

Federica Crostarosa, Ph.D.
Postdoctoral Fellow, Center for Biomedical Research, Population Council
"Carraguard-based Microbicides Prevent Vaginal Immunodeficiency Virus Infection in Naïve and HSV-2-infected Macaques"

11:00 - 11:30 a.m.

Salvatore T. Butera, DVM, Ph.D.
Centers for Disease Control and Prevention, Division of AIDS, STD and TB
"Pre-clinical Assessment of Candidate Microbicides for Safety and Efficacy Using an Animal Model Approach that More Closely Mimics Human Mucosal HIV Exposures"

11:30 a.m. - 12:25 p.m.

LUNCH

PREVENTION / Vaccine: Preston Marx/Hildegund Ertl, Session Chairs

12:25 - 12:40 p.m.

Hildegund Ertl, M.D.
Professor, Immunology Program Leader, The Wistar Institute
"HIV-1 Vaccine Platforms"

12:40 - 1:10 p.m.

Phil Johnson, M.D.
Professor of Pediatrics and Chief Scientific Officer
Children's Hospital of Philadelphia
"A Novel Strategy for SIV Neutralization"

1:10 - 1:40 p.m.

Ron Desrosiers, Ph.D.
Director, New England Primate Research Center , Harvard Medical School
"Use of Gamma-2 Herpesviruses as Vaccine Vectors for AIDS"

1:40 - 2:10 p.m.

Dan Barouch, M.D.
Associate Professor of Medicine, Harvard Medical School
"Novel Adenovirus Vector-Based Vaccines for HIV-1"

2:20 - 2:50 p.m.

Jack Rose, Ph.D.
Professor of Pathology, Yale University School of Medicine
"VSV-based Vaccines in Macaque Models of AIDS"

2:50 - 3:20 p.m.

Matthias Schnell, Ph.D.
Professor of Microbiology and Immunology, Thomas Jefferson University
"From Monkeys Back to Mice: Rabies Virus-based HIV-1 Vaccines, Molecular Adjuvant and Vector Pathogenicity"

3:20 - 3:50 p.m.

Dave Weiner, Ph.D.
Professor of Pathology and Laboratory Medicine, University of Pennsylvania
"Combination Optimization Approaches Improve the Potency of DNA Vaccines in Non Human Primates"

3:50 - 5:00 p.m.

RECEPTION, Faculty Lounge, 14th Floor of BRB II/III