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Member Information
Joshua Metlay, MD, PhD
Assistant Professor of Medicine and Epidemiology
Office Phone:
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Website(s): http://www.cceb.upenn.edu/main/people/metlay.html
Education:
Keywords: Pharmacoepidemiology, health services research, antibiotic resistance, respiratory tract infections
Research and/or Clinical Interests:
Investigating the epidemiology of emerging drug resistance among respiratory tract pathogens, with particular focus on Streptococcus pneumoniae.
Summary:
Dr. Metlay's research focused on two complimentary areas: 1) the epidemiology of drug resistance among common bacterial respiratory pathogens, particularly S. pneumoniae and 2) determinants of inappropriate antibiotic prescribing in ambulatory care settings. . Dr. Metlay is the PI of an NIAID-funded study to develop a clinical prediction rule for patients at risk of drug resistant pneumococcal pneumonia and he is the leader for one of the core projects in the AHRQ-funded Center of Excellence in Patient Safety at the University of Pennsylvania . Dr. Metlay is also one of the co-Principal Investigators of the University of Pennsylvania 's Center for Education and Research on Therapeutics (CERT). The Penn CERT is focused on expanding post-marketing research on the risks and benefits of antimicrobial drug use in both hospital and community settings and translating this knowledge into practice improvement.
Representative Publications:
Metlay JP , Hofmann J, Cetron MS, Fine MJ, Farley MM, Whitney C, Breiman RF. "Impact of penicillin susceptibility on medical outcomes for adult patients with bacteremic pneumococcal pneumonia." Clin Infect Dis. 2000;30:520-528.
Finkelstein JA, Dais RL, Dowell SF, Metlay JP , Soumerai SB, Rifas-Shiman SL, Higham M, Miller Z, Miroshnik I, Pedan A, Platt R. "Reducing antibiotic use in children: A randomized trial in 12 practices." Pediatrics. 2001;108:1-7.
Metlay JP , Shea JA, Crossette LB, Asch DA. "Tensions in antibiotic prescribing: Pitting social concerns against the interests of individual patients." J Gen Intern Med. 2002;17:87-94.
Metlay JP , Fine MJ. "Testing strategies in the initial management of patients with community-acquired pneumonia." Annals Intern Med. 2003;138:109-118.
Metlay JP , Shea JA, Asch DA. "Antibiotic prescribing decisions of generalists and infectious diseases specialists: Thresholds for choosing new therapies" Medical Decision Making. 2002;22:498-505 .
Metlay JP, Hardy C, Strom BL. "Agreement between patient self-report and a VA national pharmacy database for identifying recent exposures to antibiotics." Pharmacoepidemiology and Drug Safety. 2003;12:9-15.
Metlay JP , Strom BL, Asch DA. "Patterns of antimicrobial drug exposure and subsequent risk of trimethoprim-sulfamethoxazole resistant urinary tract infections." J Antimicrobial. Chemotherapy. 2003;51:963-970.
