Thursdays at 12:00 noon
Austrian Auditorium, Clinical Research Building
Fall 2009
September 17
 Larry Zipursky* (University of California, Los Angeles) 
"Dscam proteins, cell recognition and wiring the brain"
September 24
 Sarah Woodson (John Hopkins)
“RNA folding and ribosome assembly”
October 1
 Ned Wingreen* (Princeton University)
“Modeling adaptation in E. coli chemotaxis: precise, robust, and optimized”
October 8
 Lukas Tamm (University of Virginia)
"Structure and gating of outer membrane porins by NMR"
October 15
 Craig Peterson* (University of Massachusetts Medical School)
“Chromatin remodeling and genomic integrity”
October 22
 Peter Walter (University of California, San Francisco)
"Unfolded protein response: how the endoplasmic reticulum talks to the nucleus"
October 29
 Matthew J. Lang (M.I.T.)
"A single molecule study of kinesin and ClpXP being powered by ATP"
November 5
 Doug Barrick (Johns Hopkins University)
"Folding pathways and cooperativity in linear symmetrical proteins"
November 12
 Randy Schekman (University of Californina, Berkeley)
"Mechanism of protein sorting at the trans Golgi membrane"
December 3
 Dagmar Ringe (Brandeis University)
"Structural biology of neurodegenerative disease"
December 10
 Dan Leahy (Johns Hopkins University)
“The elegance of hedgehog signaling”
* student invited speaker
Spring 2009
January 15
 David Case (Rutgers University)
"Biomolecular simulations using continuum solvent models"
January 22
 Frederick Hughson (Princeton University)
"Directing traffic: tethers, SNAREs and vesicle transport"
January 29
 Andrej Sali (University of California, San Francisco)
"Integrating diverse data for structure determination of macromolecular assemblies"
February 5
 Scott Strobel (Yale University)
"Three views of RNA catalysis:  ribosomes, ribozymes and riboswitches"
February 19
 Susan Taylor (University of California, San Diego)
"Dynamics of PKA Signaling"
February 26
 Eva Nogales (Berkeley)
“A structural biology look at gene regulation: RNA transcription, processing and degradation machinery visualized by electron microscopy”
March 5
 Leemor Joshua-Tor (Cold Spring Harbor Laboratory)*
“DNA translocation through a replicative helicase: one step at a time”
March 19
 Peter Ogilby (University of Aarhus, Denmark)
“Singlet oxygen in single cells: killing cells softly and watching them die”
March 26
 Amy Keating (Massachusetts Institute of Technology)
“Protein interaction specificity in native and designed bZIP coiled coils”
April 2
 Stephen Benkovic (Pennsylvania State University)
“Biochemistry in the cell in the purinosome”
April 9
 Michael Rape (University of California, Berkeley)
“Chaining ubiquitin to the spindle”
April 16
 Ernesto Freire (Johns Hopkins University)
“How to achieve extremely high affinity in ligand design”
* student invited speaker
Please contact Angie Young at 215-898-4639 or younga@mail.med.upenn.edu
for additional information