 |
||||
 |
||||
 |
||||
 |
||||
 |
||||
 |
||||
 |
||||
 |
||||
|
||||
|
||||
|
||||
|
||||
|
||||
|
||||
|
||||
|
||||
PAST SYMPOSIUM
Thursday, November 19, 2009 1:00 - 1:45 p.m. 1:45 - 2:05 p.m. 2:05 - 2:50 p.m. 2:50 - 3:10 p.m. 3:10 - 3:55 p.m. 3:55 - 4:15 p.m. 4:15 - 5:00 p.m. 5:00 - 6:00 p.m.
Third Annual Chemistry-Biology Interface Picnic Friday, July 24, 2009
LASERS IN CHEMISTRY, BIOCHEMISTRY, AND MEDICINEThursday, March 19, 2009 1:30 - 2:10 p.m. 2:10 - 2:25 p.m. 2:25 - 2:40 p.m. 2:40 - 2:55 p.m. 2:55 - 3:35 p.m. 3:35 - 3:55 p.m. Coffee Break 3:55 - 4:35 p.m. 4:35 - 4:50 p.m. 4:50 - 5:05 p.m. 5:05 - 4:20 p.m. 5:20 - 6:00 p.m. 6:00 - 6:45 p.m.
OXIDATION AND REDUCTION
|
|||||||||||||||||||
|
SCHEDULE OF EVENTS |
|
|
9:20 - 10:00 a.m. |
Check-in and Breakfast, Science Center 101 |
|
10:00 - 12:00 p.m. |
MORNING SPEAKERS, Science Center 101 Michelle Bunagan, Department of Chemistry |
|
12:00 - 12:30 p.m. |
PICNIC LUNCH |
|
12:30 - 2:00 p.m. |
POSTER SESSION Mike Brent, Marmorstein Lab (Wistar/Chemistry) |
|
2:00 - 4:00 p.m. |
Afternoon Speakers Smita Mukherjee, Department of Chemistry |
|
4:00 - 4:30 p.m. |
Reception, Outdoor games |
|
4:30 – 6:00 p.m. |
Buffet Dinner |
February 22, 2007, 12:50 p.m. - 6:00 p.m.
Location: Grossman Auditorium, The Wistar Institute
12:50 p.m. – 1:40 p.m.
Michael Silverman and Farhad Abtahian
University of Pennsylvania MD/PhD Program
Dissecting a deadly virus: lessons from Avian Influenza and the Pandemic of 1918
1:40 p.m. - 1:55 p.m.
Sarah Abdulla
Ertl Group, The Wistar Institute
A flu vaccine for the elderly
1:55 p.m. - 2:10 p.m.
Vilma Decman (Post-Doctoral Fellow)
Wherry Group, The Wistar Institute
Influenza infection in aged and young mice
2:10 p.m. - 2:55 p.m.
Larry Pinto, Northwestern University
Influenza proton channels: their role in infection and mechanism for transport
2:55 p.m. - 3:10 p.m.
Amanda Stouffer (Post-Doctoral Fellow)
DeGrado Group, Department of Biochemistry and Biophysics
Amantadine binding to the M2 proton channel and the new wild type
3:25 p.m. - 3:40 p.m.
Matteo Dal Peraro (Post-Doctoral Fellow)
Klein Group, Department of Chemistry
Blocking and resistance mechanisms of M2 channel explored by molecular dynamics simulations
3:40 p.m. - 4:25 p.m.
Ted Jardetzky, Northwestern University
Structural insights into the membrane fusion mechanism of parainfluenza viruses
4:25 p.m. - 4:40 p.m.
Darya Zharikova (Post-Doctoral Fellow)
Gerhard Group, The Wistar Institute
Potential of Influenza A virus to escape protection mediated by antibodies to the matrix protein 2
4:40 p.m. - 5:25 p.m.
Judith White, University of Virginia
The fusion proteins of Influenza and Ebola Viruses
5:25 p.m. - 6:00 p.m. Reception
ORGANIZERS:
Alexei Polishchuk, Chair, BMB graduate studentFACULTY ADVISORS:
Bill DeGrado, Faculty Advisor, Biochemistry/Biophysics Faculty
Jeff Saven, Faculty Advisor, Chemistry Faculty
Robert Doms,Faculty Advisor, Microbiology FacultyORGANIZING DEPARTMENTS:
Department of Biochemistry and Biophysics
Department of Chemistry
Department of Microbiology
The Wistar Institute
SPONSORS:
Graduate Student Associations Council (GSAC)
Influmedix
The departments listed above
Thursday, October 12, 2006
Location: Carolyn Hoff Lynch Room, First Floor, Cret Wing, Chemistry Complex
1 p.m. - 6 p.m.
1:00 p.m. - 1:45 p.m.
Dongping Zhong, Ohio State University
Surface hydration dynamics and protein-water interactions
1:45 p.m. - 2:00 p.m.
Jennifer Dashnau (Graduate Student)
Vanderkooi Group, BMB Graduate Group
Small molecule effects on H-bonding in water: polyalcohol case studies
2:00 p.m. - 2:15 p.m.
Yung Sam Kim (Post-Doctoral Fellow)
Hochstrasser Group, Department of Chemistry
Ultrafast dynamics of water-peptide interactions
2:15 p.m. - 2:30 p.m.
Walter Witschey (Graduate Student)
Reddy Group, Radiology, BMB Graduate Group
Structural and functional characteristics of biological water: Lessons from MRI
2:30 p.m. - 3:15 p.m.
Theresa Head-Gordon, University of California, Berkeley
Theoretical and experimental studies of bulk water and aqueous solutions
3:30 p.m. - 4:15 p.m.
Steve Granick, University of Illinois at Urbana-Champaign
Studies of interfacial water
4:15 p.m. - 4:30 p.m.
Marco De Vivo (Post-Doctoral Fellow)
Klein Group, Department of Chemistry
The role of water in phosphatase activity in soluble epoxide hydrolase
4:30 p.m. - 4:45 p.m.
Maxim Pometun (Post-Doctoral Fellow)
Wand Group, Department of Biochemistry and Biophysics
Cold-induced unfolding of encapsulated proteins
4:45 p.m. - 5:30 p.m.
Ken Dill, University of California, San Francisco
Modeling water, the hydrophobic effect, and ion solvation
5:30 p.m. - 6:00 p.m. Reception
CHAIR:
Nathaniel Nucci, Chair, BMB graduate student
FACULTY ADVISORS:
Jeff Saven, Department of Chemistry
Jane Vanderkooi, Department of Biochemistry and BiophysicsSPONSORS:
The Graduate and Professional Student Assembly (GAPSA)
Thursday, April 27, 2006
Class of '62 Auditorium, Ground Floor, John Morgan Bldg.
1 p.m. - 6 p.m.
1:00 p.m. - 1:35 p.m.
Jeffery Kelly, The Scripps Research Institute
Understanding and ameliorating misfolding diseases
1:40 p.m. - 1:52 p.m.
Eric Greenbaum, Department of Pharmacology
Advisor: Walter Englander
The structure and folding of alpha synuclein amyloid: insights from hydrogen exchange and electron microscopy
1:55 p.m. - 2:07 p.m.
Pramit Chowdhury, Department of Chemistry
Advisor: Feng Gai
Computer aided design of small peptides for serpin depolymerization
2:10 p.m. - 2:45 p.m.
Peter Lansbury, Harvard Medical School
Therapeutic approaches to disease-modifying drugs for Parkinson's Disease
2:50 p.m. - 3:02 p.m.
Casey H. Londergan, Department of Chemistry
Advisor: R.M. Hochstrasser
The onset of peptide aggregation monitored by two-dimensional infrared spectroscopy
3:25 p.m. - 4:00 p.m.
Ron Wetzel, University of Tennessee
Energetics of amyloid assembly
4:05 p.m. - 4:17 p.m.
Sheldon Park, Department of Chemistry
Advisor: Jeff Saven
Simulation of pH-dependent edge strand rearrangement in human b-2 microglobulin
4:20 p.m. - 4:32 p.m.
Jun Han, Department of Chemistry
Advisor: Hai-Lung Dai
Detection of b-Amyloid peptide oligomers in Alzheimer's Disease through single-pair FRET microscopy
4:35 p.m. - 5:10 p.m.
Robert Tycko, National Institutes of Health
Molecular structures of fibrils associated with amyloid diseases and yeast prions
5:15 p.m. - 6:00 p.m. Reception
CHAIR:
Kesav Kumar, Chair, Chemistry Graduate Student
FACULTY ADVISORS:
Walter Englander, Department of Biochemistry and Biophysics
Robin Hochstrasser, Department of Chemistry
Virginia Lee, Center for Neurodegenerative ResearchSPONSORS:
OLIS, Inc.
The Provost’s Interdisciplinary Seminar Fund
Graduate Student Associations Council (GSAC)
Thursday, March 9, 2006
Austrian Auditorium, Clinical Research Building
1 p.m. - 6 p.m.
1:00 - 1:35 p.m.
Eugene Koonin, NCBI-NIH
Unifying measures of protein function and evolution
1:40 - 1:55 p.m.
Feng Chen, Advisor: Jeff Saven/David Roos
Department of Chemistry
A quantitative comparative analysis of ortholog identification methods
2:00 - 2:15 p.m.
Tammer Farid, Advisor: Les Dutton/Chris Moser
Department of Biochemistry and Biophysics
Electron tunneling simulations in the mitochondrial respiratory chain
2:20 - 2:55 p.m.
Roland Dunbrack, Fox Chase Cancer Center
Predicting the structure of proteins and protein complexes
3:20 - 3:55 p.m.
Olivier Lichtarge, Baylor University
Annotation and re-design of proteins"
4:00 - 4:15 p.m.
Ravindra Venkatramani, Advisor: Ravi Radhakrishnan
Department of Bioengineering
Studying the DNA replication cycle in a high fidelity polymerase by molecular dynamics simulations
4:20 - 4:35 p.m.
John Skinner, Advisor: Kim Sharp
Department of Biochemistry and Biophysicss
Pump probe MD: locating allosteric pathways
4:40 - 5:15 p.m.
Mark Gerstein, Yale University
Understanding protein function on a genome-scale using networks
5:20 - 6:00 p.m. Reception
CHAIR:
Thomas Petty, Chair
Genomics and Computational Biology (GCB) Graduate StudentFACULTY ADVISORS:
Jeff Saven, Chemistry Faculty
Kim Sharp, Biochemistry/Biophysics Faculty
Lyle Unger, Computer and Informations Sciences Faculty
David Roos, Biology Faculty
Junhyong Kim, Biology Faculty
Sridhar Hannenhalli, Genetics Faculty
This event is sponsored by the
Greater Philadelphia Bioinformatics Alliance
and The Provost’s Interdisciplinary Seminar Fund
NOVEMBER 17, 2005
Auditorium, Biomedical Research Building II/III
1 p.m. - 6 p.m.
1:00 - 1:40 p.m.
David Bocian, University of California Riverside
Hybrid semiconductor/molecular memories
1:40 - 2:00 p.m.
H. Chris Fry, Department of Chemistry
De novo designed proteins binding non-biological cofactors
2:00 - 2:20 p.m.
Hongling Zou (Graduate Student)
Department of Chemistry
Molecular dynamics study of heme cofactor binding to amphiphilic 4-helix bundle peptides at soft interfaces
2:20 - 3:00 p.m.
Joan Valentine, University of California, Los Angeles
Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis (ALS)
3:20 - 4:00 p.m.
John Shelnutt, Sandia National Laboratories & University of New Mexico
Ionic self-assembly of porphyrin nanostructures for artificial photosynthesis
4:00 - 4:20 p.m.
Olga Finikova (Postdoctoral Fellow), Department of Biochemistry and Biophysics
Symmetrically π-extended porphyrins: versatile near-infrared chromophores for biomedical applications
4:20 - 4:40 p.m.
Gretchen Bender (Graduate Student), Department of Biochemistry and Biophysics
Correlating structure and function of de novo designed metalloporphyrin proteins
4:40 - 5:20 p.m.
Joel Friedman, Albert Einstein College of Medicine
Probing the functional role of equilibrium & non-equilibrium protein dynamics in hemeproteins using sol-gel encapsulation protocols
5:25 - 6:00 p.m. Reception
CHAIR:
David Finkelstein, BMB Graduate StudentFACULTY ADVISORS:
Michael Therien, Department of Chemistry
Jane Vanderkooi, Department of Biochemistry and BiophysicsSPONSORS:
Bruker Biospin
The Provost’s Interdisciplinary Seminar Fund
Graduate Student Associations Council (GSAC)
OCTOBER 25, 2005
Grossman Auditorium, Wistar Institute, 36 & Spruce Streets
1 p.m. - 6 p.m.
Novel Membrane Studies:
1:00 - 1:30 p.m.
Ian Murray (Postdoctoral Fellow)
Advisor: Paul Axelsen, Pharmacology
Membrane-mediated amyloidogenesis
1:30 - 2:00 p.m.
Jia Zeng (Graduate Student)
Advisor: Hai-Lung Dai, Chemistry
Real-time, nonlinear optical probe of molecular transport across Living E.coli cell membranes
2:00 - 2:30 p.m.
Matthew J. Tucker (Graduate Student)
Advisor: Feng Gai, Chemistry
A new FRET technique to probe the folding dynamics of membrane binding peptides
2:30 - 3:00 p.m.
Qing Luo (Postdoctoral Fellow)
Advisor: Britton Chance, BMB
Non-invasive optical probing of prefrontal cortex function in students
Mechanisms of Molecular Recognition:
3:15 - 3:45 p.m.
Joe Swift (Graduate Student)
Advisor: Ivan Dmochowski, Chemistry
"Application and optimization of ferritin: nature’s template for inorganic nanoparticle synthesis"
3:45 - 4:15 p.m.
Troy Messick (Postdoctoral Fellow)
Advisor: Ronen Marmorstein, Wistar
"Structure of the OTU deubiquitinating enzyme bound to ubiquitin"
4:15 - 4:45 p.m.
Sung-wook Choi (Graduate Student)
Advisors: Bill DeGrado and Jeffrey Winkler, Chemistry
"Bioactive arylamide foldamer"
4:45 - 5:15 p.m.
Sheldon Park (Postdoctoral Fellow)
Advisor: J.G. Saven, Chemistry
Biophysical studies and computational design of a DNA binding protein
5:15-6:00 Reception
CHAIR:
Daniel Dowling, Chair, Department of ChemistryFACULTY ADVISORS:
Dewey McCafferty,Department of Biochemistry and Biophysics
Bill DeGrado, Department of Biochemistry and Biophysics
Feng Gai, Department of ChemistrySPONSORS:
Optical Apparatus Company
The Provost’s Interdisciplinary Seminar Fund
Graduate Student Associations Council (GSAC)
Thursday, April 21, 2005
Carolyn Hoff Lynch Room, First Floor, Cret Wing, Chemistry Complex
1:00 p.m. – 6:00 p.m.
1:00 - 1:40 p.m.
Enrico Gratton, University of Illinois at Urbana-Champaign
Tracking molecules in cells using a two-photon microscope
1:40 - 1:55 p.m.
Jia Tang (Graduate Student)
Advisor: Feng Gai, Department of Chemistry
Single molecule study of protein polymerization
2:00 - 2:15 p.m.
Jennifer Ross (Postdoctoral Fellow)
Advisor: Yale Goldman, Dept. of Biochemistry and Biophysics
Direct observation of single dynein-dynactin complexes walking along microtubules in vitro
2:20 - 2:55 p.m.
Julio Fernandez, Columbia University
Force-quench studies of protein folding
3:20 - 3:55 p.m.
Sunney Xie, Harvard University
From in vitro to in vivo single molecule studies
4:00 - 4:15 p.m.
Alexey Sharonov (Postdoctoral Fellow)
Advisor: Robin Hochstrasser,Department of Chemistry
Real time imaging of protein interactions with living cells
4:20 - 4:35 p.m.
Nishant Bhasin (Graduate Student)
Advisor: Dennis Discher, Dept. of Chemical Engineering
Chemistry on a single protein, VCAM-1, during forced unfolding
4:40 - 5:15 p.m.
Justin Molloy,National Institute for Medical Research, London
Single molecule mechanical and optical studies: in vitro and inside live mammalian cells
5:20 - 6:00 p.m. Reception
CHAIR:
Joe LaaksoFACULTY ADVISORS:
Yale Goldman, Department of Physiology
Feng Gai, Department of ChemistrySPONSORS:
Optical Apparatus Company
The Provost’s Interdisciplinary Seminar Fund
Graduate Student Associations Council (GSAC)
Thursday, March 10, 2005
Austrian Auditorium, Clinical Research Building
1:00 p.m. – 6:00 p.m.
1:00 - 1:40 p.m.
Lynne Regan, Yale University
Structure, function, and folding of designed repeat proteins
1:40 - 1:55 p.m.
Jing He (Graduate Student)
Advisor: Jeff Saven, Department of Chemistry
Computational design of anesthetic binding ion channel model
2:00 - 2:15 p.m.
Michelle DeRitter (Graduate Student)
Advisor: Feng Gai, Department of Chemistry
Fast folding of Trp-cage mini-proteins
2:20 - 3:00 p.m.
Themis Lazaridis, City College of New York
Energy functions for membrane proteins
3:20-4:00
Karyn O’Neil, Centocor, Inc
Epitope directed panning for selection of an anti-tissue factor surrogate antibody
4:00 - 4:15 p.m.
Vikas Nanda (Postdoctoral Fellow)
Advisor: Bill DeGrado, Dept. of Biochemistry & Biophysics
Doubling the design alphabet - varying backbone and sidechain stereochemistry
4:20 - 4:35 p.m.
Ting Xu (Postdoctoral Fellow)
Advisor: Kent Blasie, Department of Chemistry
Design, synthesis & characterization of novel electronic biomolecular materials
4:40 - 5:20 p.m.
Michael Hecht, Princeton University
Protein design unplugged: novel proteins from combinatorial libraries
5:20 - 6:00 p.m. Reception
CHAIR:
Scott ShandlerFACULTY ADVISOR:
Bill DeGrado, Department of Biochemistry and Biophysics
Jeff Saven, Department of ChemistrySPONSORS:
SynPep
The Provost’s Interdisciplinary Seminar Fund
Thursday, November 18, 2004
JMB Reunion Hall, John Morgan Building
1:00 p.m. – 6:00 p.m.
1:00 - 1:40 p.m.
Eddy Arnold, Rutgers University
Aiming at a rapidly evolving target: drug and vaccine design against HIV/AIDS
1:40 - 1:55 p.m.
Brandi Sanders (Graduate Student)
Advisor: Ronen Marmorstein, The Wistar Institute
Structure-based activation of Sir2 proteins
2:00 - 2:15 p.m.
Klara Stefflova (Graduate Student)
Advisor: Gang Zheng, Department of Radiology, UPHS
Photodynamic therapy agent with built-in apoptosis sensor (PDT-BIAS)
2:20 - 3:00 p.m.
William Jorgensen, Yale University
Protein-ligand binding and structure-based drug design
3:20 - 4:00 p.m.
William Moore Jr, Locus Pharmaceuticals
4:00 - 4:15 p.m.
Howard Bregman (Graduate Student)
Advisor: Eric Meggers, Department of Chemistry
A new avenue to highly potent protein kinase inhibitors
4:20 - 4:35 p.m.
Seth Snyder (Postdoctoral Fellow)
Advisor: Bill DeGrado, Department of Biochemistry and Biophysics
4:40 - 5:20 p.m.
Chris Walsh, Harvard Medical School
Glycosyltransferases dedicated to the maturation of antibiotics
5:20 - 6:00 p.m. Reception
CHAIR:
Michael BrentFACULTY ADVISORS:
Dewey McCafferty, Department of Biochemistry and Biophysics
Ronen Marmorstein, Department of ChemistrySPONSORS:
Merck Research Laboratories
The Provost’s Interdisciplinary Seminar Fund
Thursday, April 22, 2004
Carolyn Hoff Lynch Seminar Room, Cret Chemistry Building
1:00 p.m. – 6:00 p.m.
1:00 - 1:45 p.m.
Paul A. Lindahl, Texas A&M University, College Station, TX
Acetyl-coenzyme A synthase: the case for a Ni(0)-based mechanism of catalysis
1:50 - 2:05 p.m.
Frank V. Cochran (Postdoctoral Fellow)
Department of Biochemistry and Biophysics
de novo design and characterization of a four-helix bundle protein that selectively binds a non-biological cofactor
2:10 - 2:55 p.m.
Carol A. Fierke, University of Michigan, Ann Arbor, MI
Function of Zn(II) and Mg(II) in protein prenyltransferases
3:20 - 4:05 p.m.
Tom L. Poulos, University of California, Irvine, CA
Transfer in heme enzymes: intermediates, radicals, and electron transfer in heme enzymes: peroxidases as a model system"
4:10 - 4:25 p.m.
German Gomez (Graduate Student)
Department of Chemistry
Phosphatase activity in human epoxide hydrolase
4:30 - 5:15 p.m.
John D. Lipscomb, University of Minnesota, MN
Keys to the castle gate: the basis for specificity in methanse oxidation by methane monooxygenase
5:20 - 6:00 p.m. Reception
CHAIR:
Herschel WadeFACULTY ADVISORS:
Joe Jarrett, Department of Biochemistry and Biophysics
Ivan Dmochowski, Department of ChemistrySPONSORS:
Polymedix
Provost’s Interdisciplinary Seminar Fund
Thursday, February 26, 2004
Austrian Auditorium, Clinical Research Building
1:00 p.m. – 6:00 p.m.
1:00 - 1:40 p.m.
Donald M. Engelman, Yale University
Membrane protein folding and evolution
1:50 - 2:05 p.m.
Ronald Peterson (Postdoctoral Fellow)
Department of Biochemistry and Biophysics
Induced folding of metastable proteins
2:10 - 2:25 p.m.
Mallela M. G. Krishna (Postdoctoral Fellow)
Department of Biochemistry and Biophysics
Residue resolved structure, stability, folding and unfolding rates of a kinetic protein folding intermediate
2:30 - 3:10 p.m.
George Rose, Johns Hopkins University
Proteins: the unfolding story
3:40 - 3:55 p.m.
Ting Wang (Postdoctoral Fellow)
Department of Chemistry
Ultrafast folding of a three-helix bundle:1prb
4:00 - 4:15 p.m.
Chong Fang (Graduate Student)
Department of Chemistry
Dynamics and interactions within alpha-helices by 2D IR
4:20 - 5:00 p.m.
Martin Gruebele, University of Illinois at Urbana-Champaign
Folding kinetics and dynamics of proteins on rough energy landscapes
5:15 - 6:00 p.m. Reception
CHAIR:
Sabrina BédardFACULTY ADVISORS:
Walter Englander, Department of Biochemistry and Biophysics
Feng Gai, Department of ChemistrySPONSORS:
Proterion
Graduate Student Associations Council (GSAC)
Thursday, November 20, 2003
Carolyn Hoff Lynch Room, Chemistry Building, Cret Wing
1:00 p.m. - 5:15 p.m.
1:00 - 1:40 p.m.
Phil Cole, Johns Hopkins University
Bisubstrate analogs for probing structure and function of protein kinases and HATs
1:50 - 2:05 p.m.
Jason Chruma (Postdoctoral Fellow)
Department of Chemistry
Inhibition of the protein-protein interaction that occurs when the AIDS virus attacts T-cells
2:10 - 2:25 p.m.
Jaskiran Kaur (Postdoctoral Fellow)
Department of Chemistry
Design and testing of peptides as inhibitors of ribonucleotide reductase
2:30 - 3:10 p.m.
Zhiping Weng, Boston Univesity
An integrated approach to protein-protein docking
3:40 - 3:55 p.m.
Kendra Frederick (Graduate Student)
Department of Biochemistry and Biophysics
Comparison of the dynamics of complex formation between calmodulin and different calmodulin binding domain peptides
4:00 - 4:15 p.m.
Lumelle Schneeweis (Graduate Student)
Department of Biochemistry and Biophysics
Elucidation of the stoichiometry of binding of RANKL to its receptor, RANK, and to its decoy receptor, osteoprotegerin
4:20 - 5:00 p.m.
Craig Crews, Yale University
Chemical genetics: probing protein function with small molecules
CHAIR:
Lumelle Schneeweis
FACULTY ADVISORS:
Jeff Saven, Department of Chemistry
Marcos Milla, Department of Biochemistry and BiophysicsSPONSORS:
Biacore
Provost’s Interdisciplinary Seminar Fund
