BRITTON CHANCE, Ph.D., Sc.D. (Cantab.), M.D. (Hon)

Eldridge Reeves Johnson University Professor Emeritus of Biophysics,
Physical Chemistry, and Radiologic Physics
Member of the National Academy of Sciences
Foreign Member of the Royal Society
Member of the American Philosophical Society

Location: 250 Anatomy-Chemistry Building
Tel: (215) 222-1888
Fax: (215) 573-2085
Email: chance@mail.med.upenn.edu

Ph.D. University of Pennsylvania (1940)
Ph.D. Cambridge University (1942)
D. Sc. Cambridge University (1952)


DESCRIPTION OF RESEARCH INTERESTS:
  • The study of the basic theory of photon migration through tissues.
  • The use of picosecond pulsed and high frequency modulation of near infrared (NIR) light in human brain, breast and muscle, to characterize tissue optical properties.
  • The use of imaging systems to detect breast tumor; hemorrhage deep within tissues; and human brain function in cognitive activity.
RECENT REPRESENTATIVE PUBLICATIONS:

  1. Chance, B., Cope, M., Gratton, E., Ramanujam, N. and Tromberg, B. (1998) Phase measurement of light absorption and scatter in human tissues. Rev. Sci. Instru. 689:3457-3481.
  2. Chance, B. Anday, E., Nioka, S., Zhou, S., Long, H., Worden, K., Li, C., Turray, T., Ovetsky, Y., Pidikiti, D. and Thomas, R. (1998) A novel method for fast imaging of brain function, non-invasively, with light. Optics Express 2:411-423. http://epubs.osa.org/opticsexpress/ May 11, 1998 issue
  3. Chance, B., Luo, Q., Nioka, S., Alsop, D.C. and Detre, J.A. (1997) Optical investigations of physiology: a study of biomedical contrast: intrinsic and extrinsic. Phil. Trans. R. Soc. Lond. B 352:707-716.
  4. Chance, B. (1997) Near infrared images using continuous, phase modulated and pulsed light with qantitation of blood and oxygenation. Ann. New Acad. Sci. 838:29-45.
  5. Li, X.D., T. Durduran, A.G. Yodh, B. Chance and D.N. Pattanayak (1997) Diffraction tomography for biochemical imaging with diffuse-photon density waves. Optics Lett. 22:573-575.
  6. Chance, B., Kang, K., He, L., Liu, H. and Zhou, S. (1996) Precision localization of hidden absorbers in body tissues with phased-array optical systems. Rev. Sci. Instru. 67:4324-4332.
  7. Yodh, A. and B. Chance (1995) Spectroscopy and imaging with diffusing photons. Phys. Today pp 34-40.



Directions to Dr. Chance's lab in the Anatomy-Chemistry Building