Antimicrobial Dosage Regimens

Drug

Dosage Regimen

Amikacin

15mg/kg x1 (round to the nearest 50mg increment)

click here to determine subsequent doses

Aztreonam*

2gm IV q 8 hr

Cefepime*

1gm IV q 8 hr

Levofloxacin*

750mg IV q 24 hr

Metronidazole

500mg IV q 12hr

Vancomycin

≤ 70kg = 1 gm x 1, > 70kg = 1.5gm x 1

click here to determine subsequent doses

*Dosage adjustments required with renal dysfunction.

 

Antimicrobial Administration and Compatibility

 

 

Infusion time

Not compatible

Amikacin

30 minutes

Metronidazole

Aztreonam

15 minutes

Vancomycin, metronidazole

Cefepime

IV push over 5 minutes

Vancomycin

Levofloxacin

500 mg- 60 minutes

750 mg- 90 minutes

Compatible with all agents coadministered per algorithm

Metronidazole

30 minutes

Aztreonam, amikacin

Vancomycin

60 minutes for 1 gram

90 minutes for > 1 gram

Aztreonam, cefepime

Reference: Trissel’s™2 Clinical Pharmaceuticals Database (Parental Compatibility)

 

Updated 3/09

Back to Table of Contents