Graduate Medical Education
University of Pennsylvania Medical Center Guidelines for Antimicrobial Therapy
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Graduate Medical Education
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| n | S | I | R | n | S | I | R | |
| Penicillin | 24 | 100 | 0 | 0 | 93 | 88 | 3 | 8 |
| Ceftriaxone | 24 | 100 | 0 | 0 | 36 | 83 | 14 | 3 |
| Levofloxacin | 24 | 100 | 0 | 0 | 92 | 96 | 1 | 3 |
| Erythromycin | 24 | 96 | 0 | 4 | 92 | 79 | 1 | 20 |
| Clindamycin* | 24 | 96 | 0 | 4 | 92 | 79 | 1 | 20 |
| Cotrimoxazole (Sulfa-TMP) | 24 | 92 | 0 | 8 | 92 | 84 | 1 | 15 |
| Vancomycin | 9 | 100 | 0 | 0 | 33 | 100 | 0 | 0 |
| *erythromycin-resistant isolates were tested for induction of clindamycin resistance - no induced resistance was detected |
| 2011 CLSI Breakpoints for S. pneumoniae | |||
S |
I |
R |
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| Penicillin G-pneumonia | <=2 | 4 | >=8 |
| Penicillin G- meningitis & PenVK for pneumonia | <=0.06 | 0.12-1 | >=2 |
| Levofloxacin | <=2 | 4 | >=8 |
| Ceftriaxone | <=1 | 2 | >=4 |
| Erythromycin | <=0.25 | 0.5 | >=1 |
| Clindamycin | <=0.25 | 0.5 | >=1 |
| Cotrimoxazole | <=0.5/9.5 | 1/19.-2/38 | >=4/76 |
| Vancomycin | <=1 | ||
| Isolates that are susceptible to penicillin can be considered susceptible to ampicillin, amoxicillin, amoxicillin/clavulanate, ampicillin/sulbactam, cefepime, cefotaxime, ceftriaxone, and imipenem for approved indications. Note that the CLSI changed the penicillin G breakpoints for pneumococcal pneumonia in 2008, which had the effect of placing many more isolates in the "S" category. There remain different breakpoints for pneumococcal meningitis, and there is a new category for the treatment of pneumococcal pneumonia with PenVK. |
View Inpatient Susceptibility Results
Archived pneumococcal susceptibility data January 2001-Dec2006
Archived pneumococcal susceptibility data 2007
Archived pneumococcal susceptibility data 2008
Archived pneumococcal susceptibility data 2010-2011
updated 4/10/13 P. Edelstein
