Philadelphia Veterans Affairs Medical Center
Assistant Professor of Medicine

E-Mail

Philadelphia Veterans Affairs Medical Center
Cardiology 8th Floor
University & Woodland Avenues
Philadelphia, PA 19104

Appointments
Contact: Janet Genovese (215) 823-4290

Clinical Specialty:

• Cardiovascular Medicine

Practice Location:

• Philadelphia Veterans Affairs Medical Center

Education:

• MD: Catholic University of Santa Maria School of Human Medicine
• Residency: University of Miami School of Medicine / Jackson Memorial Medical Center
• Fellowship: University of Miami School of Medicine / Jackson Memorial Medical Center
• Postdoctoral Training: University of Miami Schools of Medicine and Public Health

Research Interest:

• Role of arterial stiffness and central hemodynamics as predictors of cardiovascular risk and determinants of left ventricular load.
• Mechanical modeling of ventricular function.
• Mechanical and genetic determinants of Left ventricular remodeling.
• Assessment of ventricular-vascular coupling through echocardiography/arterial tonometry and magnetic resonance imaging.
• Arterial dysfunction in obesity and obstructive sleep apnea

Selected Publications:

1. Chirinos JA, Zambrano JP, Chakko SC, Schob A, Goldberg RB, Perez GO, Mendez AJ: Serum-mediated intracellular cholesterol efflux activity predicts cardiovascular outcomes. Circulation 2005; 112:2446-2453.
2. Chirinos JA, Heresi GA, Velasquez H, Jy W, Jimenez JJ, Ahn E, Horstman LL, Soriano A, Zambrano JP, Ahn YS. Elevated Endothelial Microparticles, Endothelial Microparticle-Monocyte conjugates, Leukocyte and Platelet activation in Humans with Venous Thromboembolism. Journal of the American College of Cardiology. 2005 May 45;9: 1467-1471.
3. Chirinos JA, Zambrano  JP, Chakko  S, Schob A, Veerani A, Willens H, Perez GO, Mendez AJ. Aortic pressure augmentation predicts adverse cardiovascular events in patients with established coronary artery disease.  Hypertension 2005; 45: 980-985.
4. Chirinos JA; Zambrano JP; Jimenez J; Jy W; Virani S, MD;  Ahn E, Horstman LL; Castellanos A  Myerburg RJ;  Ahn YS. Correlation between endothelial cell apoptosis and Interleukin-6 levels in healthy males. American Journal of Cardiology 2005 May 15; 95(10):1258-60.
5. Chirinos JA, Zambrano JP, Veerani A, Schob A, Perez GO, Mendez AJ, Chakko SC. Relation Between Ascending Aortic Pressures and Outcomes in Patients with Angiographically Demonstrated Coronary Artery Disease. American Journal of Cardiology 2005; 96: 645– 648.
6. Chirinos JA, Franklin SS, Townsend R, Raij L:  Body Mass Index and Hypertension Hemodynamic Subtypes in the United States Adult Population: The National Health and Nutrition Examination Survey. In press, Archives of Internal Medicine.
7. Chirinos JA, David R, Bralley JA et al: Endogenous nitric oxide synthase inhibitors, arterial hemodynamics and subclinical vascular disease: The PREVENCION study. In press, Hypertension.