Assistant Professor of Medicine

E-Mail

Hospital of The University of Pennsylvania
Department of Medicine
Cardiovascular Medicine Division
6 Penn Tower
3400 Spruce Street
Philadelphia, PA 19104

Appointments

Clinical Specialty:

• Cardiovascular Medicine
• Heart Failure
• Heart Transplantation

Practice Location:

• Hospital of The University of Pennsylvania, Penn Tower

Education:

• MD: Harvard Medical School
• Residency: Brigham and Women’s Hospital
• Fellowship: Johns Hopkins Hospital
• Sc.M.: Johns Hopkins University (Clinical Investigation)

Research Interest:

Translational heart failure research including:

• Mechanisms of ventricular remodeling in humans
• Genetic and genomic approaches to studying ventricular remodeling in humans
• Role of xanthine oxidase and oxidative stress in human heart failure
• Novel therapeutics that alter cardiac structure and function

Selected Publications:

1. Cappola TP, Kass DA, Nelson GS, Berger RD, Rosas GO, Kobeissi ZA, Marbán E, Hare, JM, Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy. Circulation 2001; 104(20):2407-2411.
2. Barouch LA, Harrison RW, Skaf MM, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O’Rourke B, Rodriguez ER, Huang PL, Lima JAC, Berkowitz DE, Hare JM. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 2002; 416(6878):337-339.
3. Cappola TP, Felker GM, Kao WL, Hare JM, Baughman KL, Kasper EK. Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk. Circulation 2002; 105:1663-1668.
4. Barouch LA, Cappola TP, Harrison RW, Crone JK, Burnett AL, Hare JM. Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and hypertrophic cardiac remodeling in mice. J Mol Cell Cardiol 2003; Jun;35(6):637-44.
5. Cappola TP, Cope L, Cernetich A, Barouch LA, Irizarry RA, Parmigiani G, Durrani S, Lavoie T, Hoffman EP, Ye SQ, Garcia JGN, Hare JM. Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy. Physiological Genomics 2003; Jun 24;14(1):25-34.