Assistant Professor of Medicine
Director, Cardiovascular Genetics Core Laboratory

E-Mail

Hospital of The University of Pennsylvania
Department of Medicine
Cardiovascular Medicine Division
6 Penn Tower
3400 Spruce Street
Philadelphia, PA 19104

Appointments

Clinical Specialty:

• Cardiovascular Medicine
• Heart Failure
• Heart Transplantation

Practice Location:

• Hospital of The University of Pennsylvania, Penn Tower

Education:

• MD: University of Wisconsin
• Residency: University of Colorado Health Sciences Centerl
• Fellowship:
  Johns Hopkins Hospital (General Internal Medicine)
  NHLBI / Georgetown University Hospital (Cardiology)
  Brigham and Women's Hospital (Heart Failure / Transplantation)
• M.P.H.: Johns Hopkins School of Hygeine and Public Health

Research Interest:

• Genetic determinants of hypertensive remodeling, incident heart failure and heart failure progression
• Molecular and genetic determinants of natriuretic peptide physiology in advanced heart failure
• Corin-mediated regulation of natriuretic peptide processing
• Cis-acting regulatory variants and heart failure progression
• Epigenetic modifications in advanced heart failure

Selected Publications:

1. Markham DW, Dries DL, King LP, Leonard D, Yancy CW, Peshock RM, Willett D, Cooper RS, Drazner MH. Blacks and whites have a similar prevalence of reduced left ventricular ejection fraction in the general population: The Dallas Heart Study. Am Heart J, 2008, in press.
2. Dries DL. Relevance of molecular forms of brain natriuretic peptide for natriuretic peptide research. Hypertension. 2007 May;49(5):971-3.
3. Rame JE, Drazner, MH, Post W, Peshock R, Lima J, Cooper R, Dries, DL. Corin I555(P569) Allele is Associated with Enhanced Cardiac Hypertrophic Response to Increased Systemic Afterload. Hypertension 2007; 49: 1-8.
4. Dries DL, Victor RG, Rame JE, Cooper RS, Wu X, Zhu X, Leonard D, Ho SI, Wu Q, Post W, Drazner MH. Corin gene minor allele defined by two missense mutations is common in blacks and associated with high blood pressure and hypertension. Circulation 2005: 112 (16): 2403-10; Epub 2005, October 10.
5. Das DR, Drazner MH, Yancy CW, Stevenson LW, Gersh BJ, Dries DL. Effects of diabetes mellitus and ischemic heart disease on the progression from asymptomatic left ventricular dysfunction to symptomatic heart failure: a restrospective analysis from the Studies of Left Ventricular Dysfunction (SOLVD) Prevention Trial. Am Heart J 2004; 148 (5): 883-8.
6. Drazner MH, Rame JE, Marino EK, Gottdiener JS, Kitzman DW, Gardin JM, Manolio TA, Dries DL, Siscovick DS. Increased left ventricular mass is a risk factor for the development of a depressed ejection fraction within five years: the Cardiovascular Health Study. J Am Coll Cardiol 2004; 43 (12): 2207-15.
7. Dries DL, Yancy CW, Strong MA, Drazner MH. Racial response to angiotensin-converting enzyme therapy in systolic heart failure. Congest Heart Fail 2004; 10: 30-33.
8. Drazner MH, Rame JE, Dries DL. Third heart sound and elevated jugular venous pressure as markers of subsequent development of heart failure in patients with asymptomatic left ventricular dysfunction. Am J Med 2003; 114(6): 431-7.
9. Dries DL, Strong M, Cooper R, Drazner HL. Efficacy of ACE-inhibition in reducing progression of asymptomatic left ventricular dysfunction to symptomatic heart failure in black and white patients. J Am Coll Cardiol 2002; 40 (2): 311-17.
10. Drazner MH, Rame EJ, Stevenson LW, Dries DL. Prognostic importance of elevated jugular venous pressure and a third heart sound in patients with heart failure.  N Engl J Med 2001; 345:574-81.
11. Dries DL, Sweitzer NK, Drazner MH, Stevenson LW, Gersh BJ. Prognostic impact of diabetes mellitus in patients with heart failure according to the etiology of left ventricular systolic dysfunction.  J Am Coll Cardiol 2001; 38: 205.
12. Exner DV, Dries DL, Domanski MJ, Cohn JN. Lesser response to angiotensin-converting-enzyme inhibitor therapy in black as compared to white patients with left ventricular dysfunction. N Engl J Med 2001; 344 (18):1351.
13. Dries DL, Exner DV, Gersh BJ, Cooper HA, Carson PE, Domanski MJ. Racial differences in the outcome of left ventricular dysfunction. N Engl J Med 1999; 25: 340(8): 609-16.
14. Dries DL, Exner DV, Gersh BJ, Domanski MJ, Waclawiw MA, Stevenson LW. Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: a retrospective analysis of the SOLVD trials. J Am Coll Cardiol 1998; 32(3): 695-703.
15. Dries DL, Rosenberg YD, Waclawiw MA, Domanski MJ. Ejection fraction and risk of thromboembolic events in patients with systolic dysfunction and sinus rhythm: evidence for gender differences in the studies of left ventricular dysfunction trials. J Am Coll Cardiol 1997; 29(5): 1074-80.