Associate Professor of Medicine

E-Mail

University of Pennsylvania Medical Center
Department of Medicine
Cardiovascular Medicine Division
421 Curie Blvd., 952 BRB II/III
Philadelphia, PA 19104

Appointments
Contact: Nina Maschak (215) 898-9007

Clinical Specialty:

• Cardiovascular Medicine

Practice Location:

• VA Medical Center

Education:

• MD: Brown University
• Residency: Oregon Health Sciences University, Portland, OR
• Fellowship: UCSF, San Francisco, CA
• Postdoctoral Fellowship: UCSF, San Francisco, CA

Research Interest:

• Signaling Pathways in Vascular Development & Function
• Platelet Signaling

Selected Publications:

1. Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsia A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Joretzky GA, Kahn ML. (2003). Regulation of blood lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299(5604): 247-251.
2. Chen,H and Kahn M.L. (2003). Reciprocal signaling by integrin and non-integrin receptors during collagen activation of platelets. Molecular and Cellular Biology, 23(14): 4767-4777.
3. Larson MK, Chen H, Kahn ML, Taylor AM, Fabre JE, Mortensen RM, Conley PB, Parise LV. (2003). Identification of P2Y12-dependent and –independent mechanisms of glycoprotein V1-mediated Rap1 activation in platelets. Blood 101(4): 1409-1415.
4. Locke D, Liu C, Peng X, Chen H, Kahn ML. (2003). Fc Rgamma -independent Signaling by the Platelet Collagen Receptor Glycoprotein VI. Journal of Biological Chemistry. 278(17): 15441-8.
5. Boylan B, Chen H, Rathore V, Paddock C, Salacz M, Friedman KD, Curtis BR, Stapleton M, Newman DK, Kahn ML, Newman PJ. (2004). Newman PJ. Anti-GPVI-associated ITP: An acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. Blood. [Epub ahead of print]
6. Gardiner, E.E., Arthur, J.F., Kahn M.L., Berndt, M.C., Andres, R.K. (2004). Regulation of Platelet Membrane Levels of Glycoprotein VI by a Platelet-Derived Metaloproteinase. Blood 104(12):3611-7
7. Sarratt K, Chen H, Kahn M.L., Hammer D.A. (2004). Platelet receptor, glycoprotein VI-mediated adhesion to type I collagen under hydrodynamic flow. American Society for Biomedical Engineering 32(7):970-6
8. Xu, B., deWaal, R., Mor-Viknin, N., Hibbard, C., Markovitz, D.M., Kahn M.L. The endothelial-specific antibody PAL-E identifies a secreted form of vimentin in the blood vasculature. Molecular and Cellular Biology, 24 (20):9198-9206, 2004.
9. Frederick F. Samaha*Ý, Christopher Hibbard, Jay Sacks*, Hong Chen, Michael A. Varello*, Thomas George*, and Mark L. Kahn. Density of Platelet Collagen Receptors Glycoprotein VI and a2b1 in Patients with Myocardial Infarction, A Pilot Study. Atherosclerosis, Thrombosis and Vascular Biology, (11):e181-2.
10. Sarratt, KL, Chen, H, Zutter, MM, Santoro, SA, Hammer, DA, Kahn ML. GPVI and a2b1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood. 2005 Aug 15;106(4):1268-77.
11. Boylan B, Berndt MC, Kahn ML, Newman PJ. Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: Development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents. Blood. 2006 Mar 28; [Epub ahead of print]
12. Horii K, Kahn ML, Herr AB. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood. 2006 Apr 6; [Epub ahead of print]
13. Chen H, Zou Z, Sarratt KL, Zhou D, Lu MM, Hammer DA Kahn ML. In vivo integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. Genes and Development, 2006 Apr 15;20(8):927-32.
14. Abtahian, F., Bezman, N., Clemens, R., Sebzda, E., Cheng, L., Shattil, S.J., Kahn ML, G. A. Koretzky (2006). “Evidence for the requirement of ITAM domains but not SLP-76-GADS interaction for integrin signaling in hematopoietic cells.” Molecular and Cellular Biology, 2006 Sep;26(18):6936-49.
15. Sebzda E, Hibbard C, Sweeney S, Abtahian F, Bezman N, Clemens G, Maltzman J, Cheng L, Zhou D, Turner M, Tybulewicz V, Koretzky GA, Kahn ML, Syk and Slp-76 mutant mice reveal a cell autonomous hematopoietic cell contribution to vascular development. Developmental Cell, 2006 Sep; 11(3):349-61.
16. Samaha FF, and Kahn ML, Novel vascular roles for immunoreceptor signaling. Arterioscler Thromb Vasc Bio, in press.
17. Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, and Kahn ML. Klf2 is and essential regulator of vascular hemodynamic forces in vivo. Developmental Cell, 2006 December; 11, 845-57.