Associate Professor of Medicine

E-Mail

Hospital of the University of Pennsylvania
Department of Medicine
Cardiovascular Medicine Division
422 Curie Boulevard, 709 Stellar Chance
Philadelphia, PA 19104

Appointments
Contact: Christine Malloy (215)-573-2999

Clinical Specialty:

• Cardiovascular Medicine

Practice Location:

• Hospital of The University of Pennsylvania, 6 Penn Tower

Education:

• MD: Jefferson Medical College
• Residency: Mayo Graduate School of Medicine
• Fellowship: Mayo Clinic
• Postdoctoral Fellowship: Mayo Clinic

Research Interest:

• Myocardial remodeling and reverse remodeling
• Heart failure with preserved ejection fraction
• E-C coupling and regulation of contractility
• Endogenous cardiac repair
• Natriuretic peptide biology

Selected Publications:

1. Margulies KB and Burnett JC Jr:  Cyclic GMP phosphodiesterases limit renal responses to atrial natriuretic factor in congestive heart failure.  Journal of Cardiac Failure 1:71-80, 1994.
2. Margulies KB, Barclay PL and Burnett JC Jr:  The role of neutral endopeptidase in dogs with evolving congestive heart failure.  Circulation 91:2036-2042, 1995.
3. Dipla K, Mattiello J, Jeevanandam V, Houser SR and Margulies KB:  Myocyte Function following mechanical support of the left ventricle in humans with severe heart failure.  Circulation 97:2316-1322,1998.
4. Zafeiridis A, Jeevanandam V, Houser SR and Margulies, KB:  Regression of cellular hypertrophy following left ventricular assist device support.  Circulation 98:656-662, 1998.
5. Crabbe DL, Dipla K, Ambati S, Zafeiridis A, Welsh DC, Furukawa S, Houser SR, Margulies KB:  Gender differences in post-infarction hypertrophy in end-stage failing hearts.  J Am Coll Cardiol 41:300-306, 2003.
6. McGowan B, Scott CB, McCormick RJ, Mu A, Thomas DP, Margulies KB.  Unloading-induced remodeling in the normal and hypertrophic left ventricle.  Am J Physiol 284: H2061-H2068, 2003.
7. Chaudhary KW, Rossman EI, Piacentino V III, Kenessey A, Weber C, Gaughan JP, Ojamaa K, Klein I, Bers DM, Houser SR, Margulies KB.  Functionally significant reductions in sodium-calcium exchanger following mechanical circulatory support.  J Am Coll Cardiol 44:837-45, 2004.
8. Margulies KB, Matiwala S, Cornejo C, Olsen H, Craven WA, Bednarik D.   Mixed messages: transcription patterns in failing and recovering human myocardium. Circ Res 18;96(5):592-9, 2005.
9. Jung AS, Kubo H, Wilson RM, Houser SR, Margulies KB.  Modulation of Contractility by Myocyte-Derived Arginase in Normal and Hypertrophied Feline Myocardium. Am J Physiol Heart Circ Physiol. 290:H1756-62. 2006. 
10. Litvin J, Blagg A, Mu A, Matiwala S, Montgomery M, Berretta R, Houser S, Margulies K.  Periostin and periostin-like factor in the human heart: possible therapeutic targets.  Cardiovasc Pathol. 15(1):24-32, 2006.
11. Petre RE, Quaile MP, Rossman EI, Ratcliffe SJ, Bailey BA, Houser SR, Margulies KB.  Sex-based differences in myocardial contractile reserve.  Am J Physiol Heart Circ Physiol. 2007; (epub ahead of print)