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Emile R. Mohler, III, MD

Emile R. Mohler, III, MDDirector, Vascular Medicine
Associate Professor of Medicine

E-Mail

Hospital of the University of Pennsylvania
4 Penn Tower
Philadelphia, PA 19104

Appointments
Contact: Mary Behan (215) 662-9994
Fax: (215) 662-3255

Clinical Specialty:

  • Cardiovascular Medicine

Practice Location:

  • Hospital of the University of Pennsylvania

Education:

  • MD: Georgetown University School of Medicine
  • Residency: Georgetown University Medical Center
  • Fellowship: Indiana University Medical Center

Research Interest:

  • Cardiovascular Disease
  • Peripheral Arterial Disease
  • Vascular Calcification
  • Endothelial Function

Selected Publications:

  1. Wolfe ML, Vartanian SF, Ross JL, Bansavich L, Mohler ER, Meagher E, Friedrich CA, Rader DJ. Safety and effectiveness of Niaspan when added sequentially to a statin for the treatment of dyslipidemia Am. J. Cardiol. 87:476-479, 2001.
  2. Mohler ER, Gannon FH, Reynolds C, Kaplan FS:  Bone Formation and Inflammation in Calcified Cardiac Valves.  Circulation 103:1522-1528, 2001.
  3. Mohler ER, Mitchell M, Carpenter JP, Strandness DE, Jaff MR, Beckman JA, Gerhard M. Therapeutic thrombin injection of pseudoaneurysms: A multi-center experience.  Vascular Medicine 6:241-244, 2001.
  4. Mohler ER.  Deep Venous Thrombosis.  American College of Physicians On-line Guidelines (PIER) 2002 (http://pier.acponline.org/physicians/diseases/d202/d202.html.)
  5. Hunt JL, Fairman R, Mitchell ME, Carpenter JP, Golden M, Khalapyan T, Wolfe M, Neschis D, Millner R, Scoll B, Cusack A, Mohler ER. Bone Formation In Carotid Plaques: A Clinicopathologic Study.  Stroke 33:1214-1219, 2002.
  6. Rajagopalan S, Trachtenberg J, Mohler E, Olin J, McBride S, Pak R, Rasmussen H, Crystal R. Phase I Study of Direct Administration of a Replication Deficient Adenorvirus Vector Containing the VEGF cDNA (CI-1023) to Patients with Claudication.  Am J Cardiol; 90; 5:512-516, 2002.
  7. Jian B, Narula N, Li Q, Mohler ER, Levy RJ.  Progression of Aortic Valve Stenosis:  TGF-β1 is Present in Calcified Aortic Valve Cusps and Promotes Aortic Valve Interstitial Cell Calcification Via Apoptosis. Ann Thorac Surg 75:457-66, 2003.
  8. Mohler ER, Rajagopalan S, Olin JW, Trachtenberg JD, Rasmussen H, , Pak R, Crystal RG.  Adenoviral-mediated gene transfer of vascular endothelial growth factor in cirtical limb ischemia-safety results from a phase 1 trial.  Vascular Medicine 8:2003.
  9. Mohler ER, Hiatt WR, Olin J, Wade M, Jeffs RA, Hirsch AT.  Treatment of Intermittent Claudication with Beraprost Sodium, an Orally Active Prostaglandin I2 Analogue:  A Double-Blind, Randomized, Controlled Trial. JACC.  41:1679-1686, 2003.
  10. Mohler, ER, Hiatt WR, and Creager MA. Cholesterol reduction with atorvastatin improves walking distance in patients with peripheral arterial disease. Circulation 108 (12):1481-1486, 2003.
  11. Rajagopalan S, Mohler ER, Lederman RJ, Mendelsohn FO, Saucedo JF, Goldman CK, Blebea J, Macko J, Kessler PD, Rasmussen HS, and Annex BH. Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. Circulation 108 (16):1933-1938, 2003.
  12. Mohler ER. Peripheral arterial disease: identification and implications. Arch.Intern.Med. 163 (19):2306-2314, 2003.
  13. Wu B, Elmariah S, Kaplan F, Mohler ER.  Paradoxical Effects of Statins on Aortic Valve Myofibroblasts and Osteoblasts: Implications for End-Stage Valvular Heart Disease.  Arterioscler Thromb Vasc Biol, 25:592-597, 2005.
  14. Yu G, Durduran T, Lech G, Zhou C, Chance B, Mohler ER, Yodh AG.  Time-dependent Blood Flow and Oxygenation in Human Skeletal Muscles Measured with Near-Infrared Diffuse Optical Spectroscopies. Journal of Biomedical Optics, 10: 0240271-02402712, 2005.
  15. Shaffer RG, Greene S, Arshi A, Supple G, Bantly A, Moore J, Mohler ER Flow Cytometric Measurement of Circulating Endothelial Cells: The Effect of Age and Peripheral Arterial Disease on Baseline Levels of Mature and Progenitor Populations.  Cytometry B. 70:56-62, 2006.
  16. Jones CE, Wolf RL, Detre JA, Das B, Saha PK, Wang J, Zhang Y, Song HK, Wright AC, 4Mohler ER, Fairman RM,  Zager EL, 5Velazquez OC 5Golden MA, Carpenter JP, FW Wehrli FW.  Structural MRI of Carotid Artery Atherosclerotic Lesion Burden and Characterization of Hemispheric Cerebral Blood Flow Before and After Carotid Endarterectomy.  NMR in Biomedicine. 19:198-208, 2006
  17. Mohler ER, Herrington D, Ouyang P, Mangano C, Ritter S, Davis P, Purkayastha D, Gaitlin M, Vogel RA for the EXPLORE Investigators.  A Randomized, Double-Blind Trial Comparing the Effects of Amlodipine Besylate/Benazepril HC1 vs. Amlodipine on Endothelial Function and Blood Pressure.  The Journal of Clinical Hypertension. 8: 692-698, 2006.
  18. Shaffer RG, Greene S, Arshi A, Supple G, Bantly A, Moore J, Parmacek M, Mohler ER Effect of acute exercise on endothelial progenitor cells in patients with peripheral arterial disease. Vascular Medicine. 11:219-226, 2006.
  19. Mohler ER, Schafer AI.  Atherothrombosis: Initiation, Progression and Treatment. Williams Textbook of Hematology Chapter 126, pp 2067-2088.
  20. Mohler ER.  Mechanisms of Aortic Valve Calcification.  The American Journal of Cardiology. 94;1396-1402, 2004.
  21. Mohler ER.  Segmental Pressures and Pulse Volume Recordings of the Limbs.  American College of Physicians On-line Guidelines (PIER) 2004 (http://pier.acponline.org/physicians/diseases/d202/d202.html.)
  22. Mohler ER. Venous Insufficiency. American College of Physicians On-line Guidelines (PIER) 2006 (http://pier.acponline.org/physicians/diseases/d202/d202.html
  23. Tzou W, Mohler ER. Peripheral Arterial Disease: Diagnosis and Medical Management.  Hospital Physician, 2006.
  24. Roman MJ, Naqvi TZ, Gardin JM, Gerhard-Herman M, Jaff M, Mohler ER.  Clinical Application of Noninvasive Vascular Ultrasound in Cardiovascular Risk Stratification:  A Report from the American Society of Echocardiography and the Society of Vascular Medicine and Biology.  J Am Soc Echocardiography 2006, 19:943-954. 
  25. Gerhard-Herman M, Gardin JM, Jaff M, Mohler E, Roman M, Naqvi TZ.  Guidelines for Noninvasive Vascular Laboratory Testing:  A Report from the American Society of Echocardiography and the Society of Vascular Medicine and Biology.  J Am Soc Echocardiography 2006, 19:  955-972. 

Books:

  1. Rajagopalan S, Mukherjee D, Mohler ER.  Manuel of Vascular Diseases, Lippincott Williams and Wilkins, 2004.
  2. Mohler ER, Gerhard-Herman M, Jaff M.  Essentials of Vascular Laboratory Diagnosis, Blackwell 2005.
  3. Mohler ER and Townsend R.  Advanced Therapy in Hypertension and Vascular Disease. BC Decker Publishing 2006.