Associate Professor

E-Mail

Hospital of the University of Pennsylvania
Department of Medicine
Cardiovascular Medicine Division
Molecular Cardiology Laboratory
956 Biomedical Research Building II/III
Philadelphia, PA 19104-6160

Appointments
Contact: Nina Maschak (215) 573-3010

Clinical Specialty:

• Cardiovascular Medicine

Practice Location:

• Hospital of The University of Pennsylvania, Biomedical Research Building II/III

Education:

• PhD: Northwestern University (Molecular Biology) Evanston, Illinois
• Postdoctoral Fellowship: University of Chicago, Department of Medicine, Chicago, IL

Research Interest:

• Vascular Development
• Lung Development

Selected Publications:

1. Shu W, Jiang YQ, Lu MM., Morrisey EE Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development (2002) 129: 4831-4842.
2. Li S, Zhou D, Lu MM, Morrisey EE Advanced cardiac morphogenesis does not require heart tube fusion. Science (2004) 305:1619-1622.
3. Shu W, Cho J, Jiang Y, Zhang M, Haroutunian V, Weisz D, Perl D, Morrisey EE*, Buxbaum JD*. Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Proceedings of the National Academy of Sciences (2005) 102:9643-9648. *these laboratories contributed equally to these studies.
4. Shu W, Wang Z, Lu MM, Whitsett JA, Millar SE, Morrisey EE Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Developmental Biology (2005) 283: 226-239.
5. Wang Z, Shu W, Lu MM, Millar SE, Morrisey EE Wnt7b regulates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Molecular and Cellular Biology (2005) 25: 5022-5030.
6. Rath N, Wang Z, Lu MM, Morrisey EE LMCD1/dyxin is a novel transcriptional co-factor that restricts GATA6 function by inhibiting DNA binding. Molecular and Cellular Biology (2005) 25: 8864-8873.
7. Lobov IB, Rao S, Carroll TJ, Vallance JE, Ito M, Ondr JK, Kurup S, Glass DA, Pate MS, Shu W, Morrisey EE, McMahon AP, Karsenty G, Lang RA WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 437:417-421.
8. Yin Z, Gonzales L, Kolla V, Rath N, Zhang Y, Lu MM, Kimura S, Ballard PL, Beers MF, Epstien JA, Morrisey EE. Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. American Journal of Physiology-Lung Cell and Molecular Physiology (2006) 291: L191-199.
9. Lepore JJ, Mericko PA, Cheng L, Lu MM, Morrisey EE, Parmacek MS. GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. Journal of Clinical Investigation (2006) 116: 929-939.
10. Shen Q, Wang Y, Dimos JT, Fasano CA, Phoenix TN, Lemischka IR, Ivanova NB, Stifani S, Morrisey EE, Temple S. The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nature Neuroscience (2006) 9: 743-751.
11. Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstien JA, Morrisey EE, Margulies KB, Cappola TP. Activation of FOX transcription factors in human heart failure determined by transcriptional genomics. Circulation (2006) 114: 1269-1276.
12. Li S, Lu MM, Zhou, D., Hammes Sr, Morrisey EE. GLP-1: a novel zinc finger protein required for somatic cells of the gonad for germ cell development. Developmental Biology (2007) 301: 106-116.
13. Zhang Y, Rath N, Hannenhalli S, Wang Z, Cappola TP, Kimura S, Atochina-vasserman E, Lu MM, Beers MF, Morrisey EE. GATA and Nkx factors synergistically regulate tissue specific gene expression and development in vivo. Development (2007) 134: 189-198.
14. Shu W, Lu MM, Zhang Y, Tucker PW, Morrisey EE. Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development (2007-in press).
15. Cohen ED, Wang Z, Lepore JJ, Lu MM, Epstien JA, Morrisey EE. Wnt/b-catenin signaling promotes expansion of Isl-1 positive cardiac progenitor cells through regulation of FGF10. Under revision-Journal of Clinical Investigation.