Chief, Division of Cardiovascular Medicine
Herbert C. Rorer Professor of Medical Sciences

E-Mail

Hospital of the University of Pennsylvania
Department of Medicine
Cardiovascular Medicine Division
9.123 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104

Appointments

Contact: Denice Susini (215) 662-3140

Clinical Specialty:

• Cardiovascular Medicine

Practice Location:

• Hospital of The University of Pennsylvania, Founders Pavilion

Education:

• MD: Northwestern University
• Residency: University of Michigan Medical School
• Fellowship: Northwestern University Medical School
• Postdoctoral Fellowship: Howard Hughes Medical Institute, University of Michigan

Research Interests:

• Molecular Cardiology
• Transcriptional Control of Vascular Smooth Muscle Cell and Cardiac Myocyte Differentiation
• Angiogenesis
• Diabetic Vascular Disease

Selected Publications:

1. Morrisey EE, Tang Z. Sigrist K, Lu, MM, Jiang F, Ip HS and M.S. Parmacek. GATA-6 regulates HNF4 and is required for dif-ferentiation of visceral endoderm in the mouse embryo. Genes Dev. 12(22):3579-3590, 1998.
2. Morrisey EE, Musco S, Chen M Y-Z, Lu M M, Leiden JM, Parmacek MS: The gene encoding the motogen-responseive phos-phoprotein Bab2 is differentially regulated by GATA-6 and GATA-4 in the visceral endoderm. J Biol Chem 275(26):19949-19954, 2000.
3. Camoretti-Mercado, B., Liu, H.W., Halayko, A.J., Forsythe S.M., Kyle J., Fu, Y., McConville, J., Kogut, P., Vieira, J.E., Patel, N.M., Hershenson, M.B., Miano, J.M., Parmacek, M. S., Solway, J. Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor. J. Biol. Chem. 275(39):30387-30393, 2000.
4. Aoki, K., Ayurek, L. M., San, H., Leung, K., Parmacek, M. S., Nabel, E. G., Nabel, G. J. Restricted expression of an adenoviral vector encoding fas ligand (CD95L) enhances safety for cancer gene therapy. Molecular Therapy. 1(6):555-565, 2000.
5. Parmacek, M. S. Transcriptional programs regulating vascular smooth muscle cell development and differentiation. Current Top-ics in Developmental Biology 51:69-80, 2001.
6. Zhang , J., Kim, S.,Helmke, B.P., Yu, W.W., Du, K., Lu, M.-M., Strobeck, M. Yu, Q-C., Parmacek, M.S. Analysis of Sm22a-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Mol Cell Biol 21(4):1336-1344, 2001.
7. Li, W.E.I, Waldo, K., Linask, K.K., Wessels A., Parmacek., M.S., Kirby, M.L., Lo, C.W. An essential role for connexin43 gap junctions in mouse coronary artery development. Development 129:2031-2042. 2002.
8. Epstein, J.A., Rader, D.J., Parmacek, M.S. Perspective: Cardiovascular Disease in the postgenomic era – Lessons learned and challenges ahead. Endocrinology 143(6):2045-2050.
9. Mohler, E.R., Sehgal, C.M., Ferrari, V.A., Parmacek, M.S., Shih, A., Wilensky, R.L. A novel ultrasound method for evaluation of angiogenesis. Vascular Medicine 2002 (in press).