Assistant Professor of Medicine

E-Mail

Hospital of the University of Pennsylvania
Molecular Cardiology Research Center
907 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104

Contact: Samantha Halter (215) 898-3482

Clinical Specialty:

• Cardiovascular Medicine
• Cardiac Electrophysiology

Practice Location:

• Hospital of The University of Pennsylvania, Founders Pavilion

Education:

• PhD: University of Colorado
• MD: University of Colorado
• Residency: Hospital of the University of Pennsylvania
• Fellowship: Hospital of the University of Pennsylvania
• Postdoctoral Fellowship: University of Pennsylvania; Harvard University

Research Interest:

• Molecular Mechanisms of Cardiac Arrhythmias

Selected Publications:

1. Rho, R.W., V.V. Patel and D.Z. Kocovic. Current concepts of biventricular pacing in heart failure. In: Jessup M (ed): Heart Failure: A Clinicians Guide to Ambulatory Diagnosis and Treatment. Humana Press. 2002: 113-124.
2. Callans, D.J., F-J Ren, N. Narula, V. Patel, J. Michele, A. Gelzer and S.M. Dillon. (2002). Left ventricular catheter ablation using direct, intramural ethanol injection in swine. J. Interven. Card. Electrophysiol. 6:225-231, 2002.
3. Patel, V.V., J-F Ren and F.E. Marchlinski. A comparison of left atrial size by transthoracic echocardiography and magnetic catheter mapping. Pacing Clin. Electrophys. 25:14-17, 2002.
4. Patel, V.V., F-J Ren, M.E. Jeffery, T.J. Plappert, M.G. St. John Sutton and F.E. Marchlinski. A comparison of left atrial volume assessed by magnetic endocardial catheter mapping versus transthoracic echocardiography. Am. J. Cardiol. 91:351-354, 2003.
5. Rho, R.W., V.V. Patel, E.P. Gerstenfeld, S. Dixit, J.W. Poku, H.M. Ross, D.J. Callans and D.Z. Kocovic. Elevations in ventricular pacing threshold with the use of the Y adaptor: implications for biventricular pacing. Pacing Clin. Electrophysiol. 26:747-751, 2003.
6. Dixit, S., E.P. Gerstenfeld, R.W. Rho, V. Patel, D.J. Callans and F.E. Marchlinski. Change in distant atrial activation patterns during circumferential pacemapping of pulmonic vein ostium: implications for localizing triggers for atrial fibrillation.J. Interv. Card. Electrophysiol. 8:187-194, 2003.
7. Arad, M., I.P. Moskowitz, V.V. Patel, F. Ahmad, A.R. Perez-Atayde, D.B. Sawyer, M. Walter, G.H. Li, P.G. Burgon, C.T. Magurie, D. Stapleton, J.P. Schmidt, X.X. Guo, A. Pizard, S. Kupershmidt, D.M. Roden, C.I. Berul, C.E. Seidman and J.G. Seidman. Transgenic mice overexpressing mutant PRKAG2 defines the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation. 107:2850-2856, 2003.
8. Patel, V.V., M. Arad, I.P.G. Moskowitz, C.T. Maguire, D. Branco, J.G. Seidman, C.E. Seidman and C.I. Berul. Electrophysiological characterization and postnatal development of ventricular preexcitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome. J. Am. Coll. Cardiol. 42:942-951, 2003.
9. Maguire, C.T., H. Wakimoto, V.V. Patel, P.E. Hammer and C.I. Berul. Implications of ventricular arrhythmia vulnerability during murine electrophysiology studies.Physiol. Genomics. 15:84-91, 2003.
10. Rajawat, Y., E.P. Gerstenfeld, V.V. Patel, R.W. Rho, S. Dixit, D.J. Callans and F.E. Marchlinski. Surface ECG criteria for localizing the pulmonary vein origin of spontaneous atrial complexes: validation using intracardiac recordings.Pacing Clin. Electrophysiol. 2004; 27:182-188.
11. Moskowitz, I.P.G., A. Pizard, V.V. Patel, B.G. Bruneau, J.B. Kim, S. Kupershmidt, D. Roden, C.I. Berul, C.E. Seidman, J.G. Seidman. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development 131:4107-4116, 2004.
12. Patel, V.V., R.W. Rho, E.P. Gerstenfeld, H.H. Hsia, D.J. Callans, F.E. Marchlinski. Right bundle branch block ventricular tachycardias: septal versus lateral ventricular origin based on activation time to the right ventricular apex. Circulation 110:2582-2587, 2004.
13. Rajawat, Y., V.V. Patel, E.P. Gerstenfeld, H. Nayak, F.E. Marchlinski. Advantages and pitfalls of combining device-based and pharmacological therapies for the treatment of ventricular arrhythmias: experience from a large tertiary center. Pacing Clinical Electrophysiology 27:1670-1681, 2004.
14. Kostetskii, I., J. Li, Y. Xiong, R. Zhou, V.A. Ferrari, V.V. Patel, J.D. Molkentin, G.L. Radice. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circulation Research 96:346-54, 2005.
15. Russo, A.M., W. Sauer. E.P. Gerstenfeld, H.H. Hsia, D. Lin, J.M. Cooper, S. Dixit, R.J. Verdino, H.M. Nayak, D.J. Callans, V. Patel, F.E. Marchlinski. Defibrillation threshold testing: is it really necessary at the time of implantable cardioverter-defibrillator insertion? Heart Rhythm 2:456-61, 2005.
16. Ismat, F.A., Z. Maozhen, H. Kook, B. Huang, R. Zhou, V.A. Ferrari, J.A. Epstein, V.V. Patel. The homeobox protein Hop functions in the adult cardiac conduction system. Circulation Research 96:898-903, 2005.
17. Li, J.*, V.V. Patel*, I. Kostetskii, Y. Xiong, A.F. Chu, J.T. Jacobson, C. Yu, G.E. Morley, J.D. Molkentin, G.L. Radice. Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circulation Research 97:474-481, 2005. [Cover].
18. Li, J., V.V Patel, G.L. Radice. Dysregulation of cell adhesion molecules and cardiac arrhythmogenesis. Clin Med Research, 4:42-52, 2006.
19. Liu, F., F.A. Ismat, V.V. Patel. Role of homeodomain-only protein in the cardiac conduction system. Trends Cardiovasc Med, 2006 (in press).