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Muredach Reilly, MBBCh

Muredach Reilly, MBAssistant Professor of Medicine and Pharmacology

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Hospital of the University of Pennsylvania
Cardiovascular Medicine Division
Molecular Cardiology Laboratory
909 BRB II/III, 421 Curie Boulevard
Philadelphia, PA 19104

Appointments
Contact: Samantha Halter (215) 898-3482

Clinical Specialty:

  • Preventive Cardiology

Practice Location:

  • Cardiovascular Risk Intervention Program, Suite 2A, PHI Bldg., Presbyterian Hospital

Education:

  • MBBCh: University College Dublin, Ireland
  • Residency: Hospital of University of Pennsylvania
  • Fellowship: Hospital of University of Pennsylvania
  • Postdoctoral Fellowship: Hospital of University of Pennsylvania

Research Interest:

  • Inflammation, insulin resistance and atherosclerosis
  • Biomarkers of atherosclerotic cardiovascular disease
  • Genetics of atherosclerosis in chronic kidney disease and type 2 diabetes
  • Genetics of dyslipidemia in antiretroviral treated HIV-1 infected patients
  • Non-invasive imaging of atherosclerosis

Selected Publications:

  1. Reilly MP, Rader DJ. The Metabolic Syndrome: More than the Sum of its Parts. Circulation 2003;108:1546-1551.
  2. Reilly MP, Wolfe ML, Localio AR, Rader DJ. C-Reactive Protein and Coronary Artery Calcification: The Study of Inherited Risk of Coronary Atherosclerosis. Arterioscler Thromb Vasc Biol 2003;23:1851-6.
  3. Reilly MP, Wolfe ML, Localio AR, Rader DJ. Coronary artery calcification and cardiovascular risk factors: Impact of analytic approach. Atherosclerosis 2004;173:69-78.
  4. Reilly MP, Wolfe ML, Rhodes T, Girman C, Mehta N, Rader DJ. Measures of insulin resistance add incremental value to the NCEP metabolic syndrome criteria in the association with coronary atherosclerosis. Circulation 2004;110:803-9.
  5. Reilly MP, Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, Rader DJ, Kimmel SK. Plasma Leptin Levels are Associated with Coronary Atherosclerosis in Type 2 Diabetes. J Clin Endocrin Metab 2004;89:3872-8.
  6. Reilly MP, Wolfe ML, Dykhouse J, Reddy K, A Russell Localio AR, Rader DJ. Intercellular Adhesion Molecule-1 K469E Polymorphism is Associated with Reduced Coronary Atherosclerosis Independent of Plasma Levels of Soluble ICAM-1. J Invest Med 2004; 52:515-22.
  7. Lehrke ML*, Reilly MP*, Millington SC, Iqbal N, Rader DJ, Lazar, MA. An inflammatory cascade leading to hyperresistinemia in humans. PLoS Medicine 2004: (2):e45. *equal contributors
  8. Reilly MP, Lehrke ML, Wolfe ML, Lazar, MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 2005; 111:932-9.
  9. Zhang YZ, Da Silva JR, Reilly MP, Billheimer JT, Rothblat GH, Rader DJ. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest 2005; 115:2870-4.
  10. Reilly MP, Foulkes AS, Wolfe ML, Rader DJ. Higher-order lipase gene association with plasma triglycerides. J Lipid Research 2005; 46:1914-22.
  11. Reilly MP, Rader DJ. Apolipoprotein E and Coronary Disease: A Puzzling Paradox. PLoS Medicine. 2006;3:e258.
  12. Foulkes AS, Wohl D, Frank I, Puleo E, Restine S, Wolfe ML, Parker R, Dube M, Tebas P, Reilly MP. Associations among Race/Ethnicity, APOC-III/APOA-I Genotypes and Lipids in HIV-1 Infected Individuals on anti-retroviral therapy. PLoS Medicine 2006;24;3(3):e52.
  13. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006;38:320-3.
  14. Reilly MP, Rohatgi A, McMahon K, Wolfe ML, Rhodes T, Girman C, Rader DJ. Plasma cytokines, metabolic syndrome and atherosclerosis in humans. J Invest Med 2007 (In Press).
  15. Lehrke M, Millington SC, Lefterova M, Gomes Cummaranatunge R, Szapary P, Wilensky R, Rader DJ, Lazar MA, Reilly MP. CXCL16 is a Marker of Inflammation, Atherosclerosis and Acute Coronary Syndromes in Humans. J Am Coll Cardiol 2007 (In Press).
  16. Bagheri R, Schutta M, Gomes Cumaranatunge R, Wolfe ML, Terembula K, Hoffman B, Schwartz S, Kimmel SE, Farouk S, Iqbal N, Reilly MP. Value of Electrocardiographic and Ankle Brachial Index Abnormalities for Prediction of Coronary Atherosclerosis in Asymptomatic Subjects with Type 2 Diabetes Mellitus. Am J Cardiol 2007 (In press).

Sponsored Research:

  • 5-R01-HL073278-02 (PI: Reilly) 4/01/03-3/31/07
    NIH/NHLBI-NIDDK
    Inflammation, the metabolic syndrome and atherosclerosis.
    The major goals of this project are to characterize and modulate pro-atherosclerotic responses related to activation of innate immunity in humans with the metabolic syndrome.

  • 1R01-DK071224-01A1 (PI: Reilly) 2/01/06-11/30/11
    NIH/NIDDK
    Genetics of atherosclerosis in kidney disease.
    The major goals of this project are to examine the relationship of candidate innate immune and insulin resistance genes with inflammation, insulin resistance, sub-clinical atherosclerosis and cardiovascular events in the Chronic Renal Insufficiency Cohort.

  • P50 HL-083799 (SCCOR PI: FitzGerald) 4/01/06-3/31/11
    NIH/ NHLBI
    SCCOR in Vascular Injury: Lipids as modulators of the response to vascular injury
    Project 4 (PI: Reilly): Inflammatory and Metabolic Insults to the Vasculature
    The major goals of SCCOR Project 4 are to examine the role of diet, drugs and genetics on evoked atherogenic responses in humans

  • R01 AI056982-01A2 (PI: Foulkes) 3/01/05-2/28/10
    NIH/NIAID
    Analytic methods for high dimensional data in HIV research
    PENN Sub-contract (PI: Reilly)
    The major goals of this project are to develop methods for characterizing the relationship between higher order genetic data (human and HIV) and clinical phenotypes in HIV-infected humans.

  • RFA-RM-06-002 (CTSA PI: FitzGerald) 9/01/06-8/31/11
    NIH/NCRR
    Clinical and Translational Science Award (CTSA)
    Reilly: Translational Core Laboratory Director
    The purpose of this initiative is to assist institutions to forge a unique transformative, novel, and integrative academic home for Clinical and Translational Science.

Teaching Responsibilities:

  • Director, FRONTIERS Course (523): Molecular Basis of Atherosclerosis & Risk Factors, Medicine 2005-present
  • Track Director, Cardiovascular Pharmacology (Pharm 570), Pharmacology 2005-present
  • Lecturer, Pharmacology (Pharm 600), Pharmacology 2002-present
  • Instructor, Cardiovascular Physiology, Medicine 2002-present