The Cellular and Molecular Neuropathology Program seeks to discover the cellular and molecular bases of severe psychiatric illnesses, cognitive changes in aging, and neurodegenerative dementias. Given the uniquely human nature of these conditions, use of human postmortem tissues is a major approach as well as olfactory biopsy, neuron culture, and neuropathological examination of select mouse models of neurobehavioral dysfunction. In this mission, we seek insights that will translate into new and more effective therapies.