Department of Psychiatry University of Pennsylvania School of Medicine 415 Curie Boulevard, Clinical Research Building, Room 111 Philadelphia, PA 19104 phone: (215) 898-0092 fax: (215) 573-2041 wadeb@mail.med.upenn.edu

RESEARCH INTERESTS:

     The Berrettini lab studies the gnetics and pharmacogenetics of several complex traits, including nicotine dependence, opioid dependence and bipolar disorder through both animal model and human experiments.

Representative recent publications:

Lerman C, Jepson C, Wileyto EP, Epstein LH, Rukstalis M, Patterson F, Kaufmann V, Restine S, Hawk L, Niaura R, Berrettini WH: The role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials. Neuropsychopharmacology, in press.

Dahl JP, Weller A, Kampman KM, Oslin DW, Lohoff FW, Ferraro TN, O’Brien CP, Berrettini WH: Association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. Am J Med Genet 139:106-8, 2005.

Ferraro TN, Golden GT, Smith GG, Martin JF, Schwebel CL, Doyle GA, Buono RJ, Berrettini WH: Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strains. Neuropsychopharmacology 30:742-6, 2005.

Lohoff FW, Sander T, Ferraro TN, Dahl JP, Gallinat J, Berrettini WH: Confirmation of association between the Val66Met polymorphism in the brain- derived neurotrophic factor (BDNF) gene and bipolar I disorder. Am J Med Genet 139:51-3, 2005.