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Wade H. Berrettini, M.D., Ph.D., Director
Department of Psychiatry
Perelman School of Medicine
415 Curie Boulevard, Clinical Research Building, Room 111
Philadelphia, PA 19104

phone: (215) 898-0092
fax: (215) 573-2041

B.S.: 1973, Dickinson College (cum laude)
M.D.: 1977, Jefferson Medical College
Ph.D.: 1979, Thomas Jefferson University (Pharmacology)


     The Berrettini lab studies the gnetics and pharmacogenetics of several complex traits, including nicotine dependence, opioid dependence and bipolar disorder through both animal model and human experiments.

Representative recent publications:

Lerman C, Jepson C, Wileyto EP, Epstein LH, Rukstalis M, Patterson F, Kaufmann V, Restine S, Hawk L, Niaura R, Berrettini WH: The role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials. Neuropsychopharmacology, in press.

Dahl JP, Weller A, Kampman KM, Oslin DW, Lohoff FW, Ferraro TN, O’Brien CP, Berrettini WH: Association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. Am J Med Genet 139:106-8, 2005.

Ferraro TN, Golden GT, Smith GG, Martin JF, Schwebel CL, Doyle GA, Buono RJ, Berrettini WH: Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strains. Neuropsychopharmacology 30:742-6, 2005.

Lohoff FW, Sander T, Ferraro TN, Dahl JP, Gallinat J, Berrettini WH: Confirmation of association between the Val66Met polymorphism in the brain- derived neurotrophic factor (BDNF) gene and bipolar I disorder. Am J Med Genet 139:51-3, 2005.