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Andras Schaffer, M.D., Ph.D.
Instructor in Dermatology

3600 Spruce Street
2 Maloney Building
Philadelphia, Pennsylvania 19104-6142

Office: 215-349-5062
Fax: 215-615-5295
Email: andras.schaffer@uphs.upenn.edu

 
 

Education
1993     M.D.           University of Pecs School of Medicine, Hungary
2001     Ph.D.          Cornell University (Immunology)
2004     Residency    Massachusetts General Hospital
2006     Residency    University of Pennsylvania

Clinical Specialties
Dermatopathology
Cutaneous Inflammatory and Lymphoproliferative Disorders

Research Areas of Interest
Cell-Cell Fusion
Notch signaling in cutaneous inflammation and wound healing

Selected Publications

  1. Wang H.Y., A.D. Bossler, A. Schaffer, E. Tomczak, D. DiPatri, D. M. Frank, P. C. Nowell, and A. Bagg. 2007. A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma. Cancer Genet. Cytogenet. 172:45-53.

  2. Kim, E. C., C. R. Edmonston, X. Wu, A. Schaffer and P. Casali. 2004. The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells: Relevance to class switch DNA recombination. J. Biol. Chem. 279:42258.

  3. Schaffer, A., E. Kim, X. Wu, H. Zan, L. Testoni, S. Salamon, A. Cerutti and P. Casali. 2003. Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements. J. Biol. Chem. 278:23141-50.

  4. Cerutti A, H. Zan, E. Kim, S. Shah, E. Schattner, A. Schaffer and P. Casali. 2002. Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells. J. Immunol. 169:6594-603.

  5. Litinskiy MB, B. Nardelli, D. Hilbert, B. He, A. Schaffer, P. Casali and A. Cerutti. 2002. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol. 3:822-9.

  6. Cerutti, A., E. C. Kim, S. Shah, E. J. Schattner, H. Zan, A. Schaffer, and P. Casali. 2001. Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells. Nat. Immunol. 2:150-6.

  7. Zan, H., A. Komori, Z. - D. Li, A. Cerutti, A. Schaffer, M. F. Flajnik, M. Diaz, and P. Casali. 2001. The translesion DNA polymerase * plays a major role in Ig and bcl-6 somatic hypermutation. Immunity. 14:643-653.

  8. Cerutti, A., A. Schaffer, R.G. Goodwin, S. Shah, H. Zan, S. Ely and P. Casali. 2000. Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells. J. Immunol. 165:786-94.

  9. Schaffer, A., A. Cerutti, S. Shah, H. Zan, and P. Casali. 1999. The evolutionarily conserved sequence upstream of the human Ig Sγ region is an inducible promoter. Synergistic activation by CD40L and IL-4 via cooperative NF-kB and STAT-6 binding sites. J. Immunol. 162:5327-36.

  10. Zan, H., A. Cerutti, P. Dramatinos, A. Schaffer, Z.-D. Li, and P. Casali. 1998. Induction of somatic hypermutation and Ig class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: Definition of the requirements and modalities of the hypermutation. J. Immunol. 162:3437-47.

  11. Cerutti, A., A. Schaffer, S. Shah, H. Zan, H-C. Liou, R. G. Goodwin, and P. Casali. 1998. CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells. Immunity 9:247-256.

  12. Zan, H., A. Cerutti, P. Dramatinos, A. Schaffer, Z-D. Li, and P. Casali. 1998. CD40 engagement triggers switching to IgA1 and IgA2 in human B cells in the absence of other stimuli and through induction of endogenous TGF-β. Evidence for TGF-β but not IL-10-dependent direct Sμ-Sα and sequential Sμ-Sγ, Sγ-Sα DNA recombination. J. Immunol. 161:5217-25.

  13. Cerutti, A., H. Zan, A. Schaffer, L. Bergsagel, N. Harindranath, E.E. Max, and P. Casali. 1998. CD40 ligand and appropriate cytokines induce switching to IgG, IgA, IgE and coordinated germinal center and plasmocytoid phenotypic differentiation in a human monoclonal IgM+ IgD+ B cell line. J. Immunol. 160:2145-2157.

  14. Adler V., A. Schaffer, J. Kim, L Dolan, and Z. Ronai. 1995. UV irradiation and heat shock mediate JNK activation via alternate pathways. J. Biol. Chem. 270:26071-26077.



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