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Division of General Internal Medicine

EPI 550, Spring 2012

Clinical Economics and Clinical Decision Making

Faculty

Henry Glick, Ph.D.

Sankey Williams, M.D.

About the Course

Course Syllabus

Course Readings

Session 1. 1/11/12. Introduction

Administrative details

Lecture 1. Revising the Pretest Probability of Disease

Homework 1. Test for Concussion

Session 2. 1/13/12. Lecture 2. Topics in Dichotomous Test Evaluation

Session 3. 1/18/12. Lecture 3. Introduction to Diagnostic Tests with Continuously Scaled Results

Homework 2. Amyloid beta peptide test for Alzheimer's disease

Session 4. 1/20/12. Lecture 4. Stratum-Specific Likelihood Ratios (SSLR)

Critical Appraisal:El-Moamly A, El-Sweify M, Hafeez M. Performance of  rK39 immunochromatography and freeze-dried direct agglutination tests in the diagnosis of imported visceral leishmaniasis.Parasitol Res. 2012;110:349-54.

Sessions 5 and 6. 1/25/12. Lecture 5. Developing a Prediction Rule

Homework 3. Amyloid beta 1 to 24 peptidesfor the diagnosis of AD

 

Session 7. 2/1/12. Critical Appraisal and Verifiction Bias

Critical Appraisal

Stiell et al. Derivation of a decision rule for the use of radiography in acute knee injuries. Ann Emerg Med. 1995;26:405-13.

Stiell et al.Prospective validation of a decision rule for the use of radiography in acute knee injuries. JAMA. 1996;275:611-15.

Stiell et al. Implementation of the Ottawa Knee Rule for the use of radiography in acute knee injuries. JAMA. 1997;278:2075-9.

Appraisal Guide

Lecture 6. Verification Bias

Session 8. 2/3/12. Lecture 7. 2x2 vs Stratum Specific Approaches

Session 9. 2/8/12

Lecture 8. Choice Among Tests

Lectuer 9. Stability of Test Characteristics

Session 10. 2/10/12. Lecture 10. Quiz 1 and Introduction to Economic Evaluation of Healthcare

1 hour quiz followed by lecture

Sessions 11-12. 2/15/12. Lecture 11. Topics in Cost-Effectiveness Analysis

Homework 4.Cost-Effectiveness Selection Algorithms

Session 13. 2/22/12. Lecture 12

Decision Tree Analysis: HIV Prophylaxis after Occupational Exposure.

Homework 5.Decision Tree for Screening with Whole-Body CT

Session 14. 2/24/12. Lecture 13 and Homework 6.

Using TreeAge programs to create and analyze decision trees

Calculating HIV Disutilities

Alternate Trees for Hepatitis C Problem

Session 15. 2/29/12. Lecture 14. Decision Tree Sampling Uncertainty

Sessions 16 and 17. 3/2/12 and 3/14/12. Lecture 15. Introduction to Markov Models

Session 18. 3/16/12. Lecture 16.  Using Treeage to Create and Analyze Markov Models and Homework 7

Lupus trex file for static analyses

Lupus trex file for probabilistic analyses

Session 19. 3/21/12. Critical Appraisal

Smith KJ, et al. Cost-effectivenes of adult vaccination strategies using pneumococcal Conjugae vaccine compared with pneumococcal poyscaccharide vacine. JAMA. 2012;307:804-12.

Session 20. 3/23/12. Quiz 2 and Lecture 17. Utility Assessment

Homework #8. Manuscript review

 Manuscript background information

 Manuscript to be reviewed: Rosas SE, Feldman HI. Synthetic Vascular Hemodialysis Access Versus Native Arteriovenous Fistula. Ann Surg. 2012;255: 181-86.

Session 21. 3/28/12. Preference Assessment (cont.)

Homework #9. Building an osteoporosis markov model

                            Beginnings of TreeAge osteoporosis model trex file

Session 22. 3/28/12. Costing and Discounting

Practical Costing

Discounting in Economic Evaluation

Session 23. 4/4/12. Univariate Analysis of Cost Data

Homework #10. Building an osteoporosis markov model (2)

  Beginnings of Tree for homework #10

Session 24. 4/6/12 Multivariable Analysis of Cost Data

       Cost and QALY Analysis Workshop

Session 25. 4/11/12. Sampling Uncertainty for Cost-Effectiveness Analysis (part I)

Homework #11. Building an osteoporosis markov model (3)

                             Beginnings of Tree for homework #11

Session 26. 4/13/13. Sampling Uncertainty for Cost-Effectiveness Analysis (part II)

           Sampling Uncertatiny Workshop