Division of General Internal Medicine

 

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FDA, Spring 2015

Pharmacoeconomics

Faculty: Henry Glick, PhD

Course Syllabus

Session 1. Introduction

Part 1. Overview: Cost minimization, cost effectiveness, and cost benefit analysis; direct cost, productivity cost, intangible cost; perspective

Reading: Eisenberg. "Clinical Economics: a Guide to the Economic Analysis Of Clinical Practices."

Part 2. Cost-Effectiveness Analysis: Average and incremental ratios; choice criteria; strategies for identifying the cost effective therapy

Reading: Glick, Doshi, Sonnad, and Polsky. Economic Evaluation in Clinical Trials, Chapter 7

Session 1 Exercise #1

     

  Session 2. Costing, Theory and Practice

Part 1. Average versus incremental costs; fixed and variable costs; readily available sources of inpatient and outpatient cost data

Reading: Glick, Doshi, Sonnad, and Polsky. Economic Evaluation in Clinical Trials, Chapter 3.

Meyers AL, et al. Hospital cost analysis of a prospective, randomized trial of early vs interval appendectomy for perforated appendicitis in children. J Am Coll Surg. 2012; 214: 427-35.

Part 2. Inflation and Discounting

Session #2  Exercise #2

Lieu TA, et al. Cost-effectiveness of varicella serotesting versus presumptive vaccination of school-age children and adolescents. Pediatrics. 1995;95:632-8. Critical appraisal guide

The following 2 articles may help you identify key features that should be reported in economic evaluations

Drummond MF, et al. Users' Guides to the Medical Literature XIII. How to Use an Article on Economic Analysis of Clinical Practice A. Are the Results of the Study Valid? JAMA.1997;277:1557

O'Brien BJ, et al.Users' Guides to the Medical Literature XIII. How to Use an Article on Economic Analysis of Clinical Practice B. What Are the Results and Will They Help Me in Caring for My Patients? JAMA. 1997;277:1802-6.

Critical appraisal checklist

 

Session 3. Patient Preferences, Theory and Practice

Reading: Glick, Doshi, Sonnad, and Polsky. Economic Evaluation in Clinical Trials,Chapter 4.

Gold, Siegel, Russell, Weinstein, Cost-Effectiveness in Health and Medicine, Chapter 4.

Session #3  Exercise #3

Patel HY, Wagschal LD, Trope GE, Buys YM. Economic analysis of the Ex-PRESS miniature glaucoma device versus trabeculectomy. J Glaucoma. 2014; 23: 385-90.

Introduction to Sampling Uncertainty

Session 4.  Designing Economic Evaluations in Clinical Trials

Readings: Glick, Doshi, Sonnad, and Polsky. Economic Evaluation in Clinical Trials, Chapters 2 and 11
Glick, "Sample Size and Power for Cost-Effectiveness Analysis"

Session 5.  Analysis of Patient Level Outcomes

Part 1. Analysis of patient level cost data

Part 2. Sampling Uncertainty and Patient-Level Cost-Effectivenss Analysis

Readings: Glick, Doshi, Sonnad, and Polsky. Economic Evaluation in Clinical Trials, Chapter 5.

Glick, Doshi, Sonnad, and Polsky. Economic Evaluation in Clinical Trials, Chapter 8.

Final Project

Potential articles for final project

The link above describes the final group project that you will present on Wednesday, October 23. Ideally, you will form groups and identifty an article by next Wednesday (October 9) so that you will have 2 weeks to prepare your presentation.