Short Courses: Applications of Statistical Considerations in Health Economic Evaluations
ISPOR 16th Annual Meeting
1:00  5:00, May 22, 2011
Course Description:
This course will provide applications of statistical considerations in economic analysis. Specific exercises will be conducted to illustrate univariate & multivariable analysis of costs (including the effect of distributional assumptions), sample size and power calculations for costeffectiveness analysis, and estimation of confidence intervals for costeffectiveness ratios and net monetary benefits as well as acceptability curves. Participants are encouraged to have handson experience and bring their laptops. Statistical analysis will be done by use of STATA. A trial version of the software will be distributed for those who do not have the software. The text “Economic Evaluation in Clinical Trials” (Oxford: OUP, 2007) is recommended reading for this course. The course, Statistical Considerations in Economic Evaluations, is a strong prerequisite for this course.
Lectures (Updated, May 9, 2008)
Computer Programs and Data (revised 05/03/13)
Analysis of cost
 rchapter5.dta, Stata dataset
 glmdiagnostic.do, .do file that loads the program glmdiag: glmdiag evaluates the link and family for generalized linear models
 bsmultiv.do, bootstrap program custom written for rchapter5.dta. Users can modify the program for their own datasets
 bsmvpred.ispor.dta, bootstrapped dataset constructed by use of bsmultiv.do (contains 3000 bootstrapped replications)
Sampling uncertainty (revised 05/03/13)
 iprogs.do, (revised 05/05/11) immediate form programs for calculating confidence intervals for costeffectiveness ratios, confidenceintervals for NMB , and the acceptability curve
 ceagraphs.do, (revised 05/06/11, works with revised iprogs.do only) programs that when used in conjunction with fielleri, accepti, and nmbi graphically display the point estimate and confidence limits for the costeffectiveness ratio (fiellergraph), the acceptability graph (accgraph), and the point estimate and confidence limits for NMB defined for varying levels of WTP (nmbgraph). The ceagraphsdoc program provides a brief overview of the programs and the syntax for running them
 bsceaprogs.do, (last revised 5/08/11) programs for using a bootstrapped dataset to estimate confidence intervals for costeffectiveness ratios, confidenceintervals for NMB , and the acceptability curve
 bsceagraphs.do: Stata .do file ( works with revised bsceaprogs.do only). programs that when used in conjunction with bsciceri, bsaccept, and bsnmb graphically display the point estimate and confidence limits for the costeffectiveness ratio (bscicergraph), the acceptability graph (bsaccgraph), and the point estimate and confidence limits for NMB defined for varying levels of WTP (bsnmbgraph). The bsceagraphsdoc program provides a brief overview of the programs and the syntax for running them
 Bootstrap ordering problems
Sample size
 ssizeprg.do, programs for estimating sample size for costeffectiveness analysis (updated 4/1/10)
Faculty:
 Jalpa Doshi, PhD, University of Pennsylvania
 Henry Glick, PhD, University of Pennsylvania
