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Division of General Internal Medicine

Short Courses: Applications of Statistical Considerations in Health Economic Evaluations

ISPOR 17th Annual Meeting
1:00 - 5:00, June 3, 2012

Course Description:

This course will provide applications of statistical considerations in economic analysis. Specific exercises will be conducted to illustrate univariate & multivariable analysis of costs (including the effect of distributional assumptions), sample size and power calculations for cost-effectiveness analysis, and estimation of confidence intervals for cost-effectiveness ratios and net monetary benefits as well as acceptability curves. Participants are encouraged to have hands-on experience and bring their laptops. Statistical analysis will be done by use of STATA. A trial version of the software will be distributed for those who do not have the software. The text “Economic Evaluation in Clinical Trials” (Oxford: OUP, 2007) is recommended reading for this course. The course, Statistical Considerations in Economic Evaluations, is a strong prerequisite for this course.

 

 

Lectures (Updated, May 9, 2008)

Computer Programs and Data

Zip file of programs and data subdirectory

Analysis of cost

    • rchapter5.dta, Stata dataset
    • glmdiagnostic.do, .do file that loads the program glmdiag: glmdiag evaluates the link and family for generalized linear models
    • bsmultiv.do, bootstrap program custom written for rchapter5.dta. Users can modify the program for their own datasets
    • bsmvpred.ispor.dta, bootstrapped dataset constructed by use of bsmultiv.do (contains 3000 bootstrapped replications)

Sampling uncertainty (revised 05/03/13)

  • iprogs.do, (revised 05/14/12) immediate form programs for calculating confidence intervals for cost-effectiveness ratios, confidenceintervals for NMB , and the acceptability curve
  • ceagraphs.do, (revised 05/14/12, works with revised iprogs.do only) programs that when used in conjunction with fielleri, accepti, and nmbi graphically display the point estimate and confidence limits for the cost-effectiveness ratio (fiellergraph), the acceptability graph (accgraph), and the point estimate and confidence limits for NMB defined for varying levels of WTP (nmbgraph). The ceagraphsdoc program provides a brief overview of the programs and the syntax for running them
  • bsceaprogs.do, (last revised 5/08/11), programs for using a bootstrapped dataset to estimate confidence intervals for cost-effectiveness ratios, confidenceintervals for NMB , and the acceptability curve
  • bsceagraphs.do: (last revised 06/11/2011), Stata .do file (works with revised bsceaprogs.do only). programs that when used in conjunction with bsciceri, bsaccept, and bsnmb graphically display the point estimate and confidence limits for the cost-effectiveness ratio (bscicergraph), the acceptability graph (bsaccgraph), and the point estimate and confidence limits for NMB defined for varying levels of WTP (bsnmbgraph). The bsceagraphsdoc program provides a brief overview of the programs and the syntax for running them
  • Bootstrap ordering problems

Sample size

  • ssizeprg.do, programs for estimating sample size for cost-effectiveness analysis (updated 4/1/10)
Faculty:
  • Jalpa Doshi, PhD, University of Pennsylvania
  • Henry Glick, PhD, University of Pennsylvania