Division of General Internal Medicine

 

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Short Courses: Statistical Considerations in Health Economic Evaluations

ISPOR 18th Annual Meeting
8:00 - 5:00, May 19, 2013

Course Description:

Adoption and diffusion of new medical treatments depend increasingly on analysis of costs and cost-effectiveness. During this course, we discuss design issues and applications of the collection of primary economic data as well as statistical considerations, including the effect of distributional assumptions, univariate and multivariable analyses of data, sample size and power calculations, and estimation of sampling uncertainty. Participants will be guided through applications of statistical considerations in economic analysis using specific hands-on exercises.Statistical analysis will be done by use of STATA. A trial version of the software will be distributed for those who do not have the software. Participants who wish to have hands-on experience must bring their laptops.ading for this course.

 

Lectures

Workshop-Specific Computer Programs and Data

Download EITHER the zip file (contains all of the following individual Stata files) OR the individual files themselves

Zip file of programs and data subdirectory

Analysis of cost

    • rchapter5.dta, Stata dataset
    • glmdiagnostic.do, .do file that loads the program glmdiag: glmdiag evaluates the link and family for generalized linear models
    • bsmultiv.do, bootstrap program custom written for rchapter5.dta. Users can modify the program for their own datasets
    • bsmvpred.ispor.dta, bootstrapped dataset constructed by use of bsmultiv.do (contains 3000 bootstrapped replications)

Sampling uncertainty (revised 05/03/13)

  • iprogs.do, (revised 05/03/13) immediate form programs for calculating confidence intervals for cost-effectiveness ratios, confidenceintervals for NMB , the acceptability curve, and the VOI curve
  • ceagraphs.do, (revised 05/03/13, works with revised iprogs.do only) programs that when used in conjunction with fielleri, accepti, and nmbi graphically display the point estimate and confidence limits for the cost-effectiveness ratio (fiellergraph), the acceptability graph (accgraph), the point estimate and confidence limits for NMB defined for varying levels of WTP (nmbgraph), and the VOI curve (voigraph).. The ceagraphsdoc program provides a brief overview of the programs and the syntax for running them
  • bsceaprogs.do, (last revised 04/30/13), programs for using a bootstrapped dataset to estimate confidence intervals for cost-effectiveness ratios, confidence intervals for NMB , the acceptability curve, and value of information. The bsceaprogsdoc program provides a brief overview of the programs and the syntax for running them
  • bsceagraphs.do: (last revised 05/03/2013), Stata .do file (works with bsceaprogs.do only). programs that when used in conjunction with bsciceri, bsaccept, bsnmb, and bsvoi graphically display the point estimate and confidence limits for the cost-effectiveness ratio (bscicergraph), the acceptability graph (bsaccgraph), the point estimate and confidence limits for NMB for the NMB graph (bsnmbgraph), and the VOI graph. The bsceagraphsdoc program provides a brief overview of the programs and the syntax for running them
  • dataforslides.dta Stata data used in uncertainty lecture
  • Bootstrap ordering problems

Sample size

  • ssizeprg.do, programs for estimating sample size for cost-effectiveness analysis (updated 4/1/10)
Faculty:
  • Jalpa Doshi, PhD, University of Pennsylvania
  • Henry Glick, PhD, University of Pennsylvania