Short Courses: Economic Evaluation in Clinical Trials
Kurs i legemiddeløkonomi
Institutt for helseledelse og helseøkonomi
Oslo, 24.25. November 2008
Course Description: This 2day course will examine issues in the design of economic evaluations in clinical trials; sources of priceweights for the evaluation; common methods for the assessment of preference scores; evaluation of costs (didactic session and computer workshop); evaluation of sampling uncertainty for the comparison of cost and effect (didactic session, sampling uncertainty computer workshop, and sample size computer workshop), and the evaluation of the transferability of the results of the evaluation.
Lectures
Computer Programs and Data
Analysis of Cost
 rchapter5.dta Stata dataset
 glmdiagnostic.do do file that loadloads the program glmdiag: glmdiag evaluates the link and family for generalized linear models
 bsmultiv.do bootstrap program custom written for rchapter5.dta. Users can modify the program for their own datasets
 bsmvpred.dta bootstrapped dataset constructed by use of bsmultiv.do (contains 3000 bootstrapped replications)
Sampling Uncertainty / Sample Size
 iprogs.do, (revised 07/14/16) immediate form programs for calculating confidence intervals for costeffectiveness ratios (fielleri), confidence intervals for NMB (nmbi and nmb1i),the acceptability curve (accepti and accept1i) and the value of information curve (voii and voi1i). The iprogsdoc program provides a brief overview of the programs and the syntax for running them
 ceagraphs.do, (revised 07/14/16; works with revised iprogs.do only) programs that when used in conjunction with fielleri, accepti, accept1i, nmbi, nmb1i, and voii graphically display the point estimate and confidence limits for the costeffectiveness ratio (fiellergraph), the acceptability graph (accgraph and acc1graph), the point estimate and confidence limits for NMB defined for varying levels of WTP (nmbgraph) or a single level of WTP (nmb1graph), and the value of information curve (voigraph). The ceagraphsdoc program provides a brief overview of the programs and the syntax for running them
 bsceaprogs.do, (revised 07/22/15) programs for using a bootstrapped dataset to estimate confidence intervals for costeffectiveness ratios, confidenceintervals for NMB , and the acceptability curve
 bsceagraphs.do: (revised 07/22/15) Stata .do file ( works with revised bsceaprogs.do only). programs that when used in conjunction with bsciceri, bsaccept, and bsnmb graphically display the point estimate and confidence limits for the costeffectiveness ratio (bscicergraph), the acceptability graph (bsaccgraph), and the point estimate and confidence limits for NMB defined for varying levels of WTP (bsnmbgraph). The bsceagraphsdoc program provides a brief overview of the programs and the syntax for running them
 ssizeprg.do programs for estimating sample size for costeffectiveness analysis (last updated 4/1/10)
 ceapowersimulator.do program simulates trials for a given difference in cost, difference in effect, SEs of the difference in cost and effect, correlation of the difference in cost and effect, and alpha level and estimates power:
Faculty
Henry Glick, PhD, University of Pennsylvania
