Department of Anesthesiology and Critical Care

Research
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Pediatric Anesthesia Research

Ronald Litman, DO studies the Pathophysiology of upper airway obstruction during pediatric sedation and anesthesia using structural (MRI) and functional (Flow vs. Pressure curves) analyses to describe patient and agent-related factors that contribute to upper airway obstruction, and describe interventions to decrease or prevent upper airway obstruction in children.

David Jobes, MD is using outcomes research to study hemostasis and coagulation related to cardiac surgery for adult and pediatric patients.

Kha Tran, MD's area of research interest is in describing and characterizing anesthesia for fetal surgery. His primary focus involves quantifying fetal exposure to volatile anesthetic agents during open fetal surgery. As part of this, Dr. Tran is creating a registry of patients receiving anesthesia for minimally invasive fetoscopic surgery. He is also interested in optimal perioperative care of children born with sacrococcygeal teratoma.

Christopher Ward, MD is investigating anesthetic induced neurotoxicity in the developing brain using rodent models.  His work has involved examining histopathologic changes in the brain following anesthetic exposures, as well as the possible persistent learning and behavior deficits these changes cause in rats and mice.  Dr. Ward is also exploring possible biomarkers to detect anesthetic neurotoxicity.

Gordon Barr, PhD is a developmental psychobiologist who studies how nervous system maturation mediates the rapid changes in the behavior that occurs in development. He studies the mechanisms that mediate reinforcement, pain and stress, including studies on drugs that modulate these mechanisms.

Paul Stricker, MD is a clinical researcher whose interests focus on the perioperative management of children undergoing craniofacial surgery. Dr. Stricker is evaluating different techniques to minimize transfusion and associated risks in this surgical population, including the use of reconstituted blood rather than standard blood component therapy, transfusion protocols, and the use of the antifibrinolytic drug aminocaproic acid. Dr. Stricker is also actively involved in research relating to difficult airway management in pediatric patients.

Harshad Gurnaney, MD is involved in outcome studies regarding regional anesthesia techniques in pediatric patients and acute postoperative pain management research.  He is also involved in outcomes research related to neurological effects of general anesthesia and in research to evaluate simulation as an educational tool in the perioperative setting.

Scott Cook-Sather, MD has completed numerous studies on residual gastric fluid volume and pulmonary aspiration incidence as they relate to fasting guidelines for infants and children requiring anesthesia and surgery. His current research focus is the pharmacogenomics of opioids and benzodiazepines in children. As a departmental Patient Safety Officer at CHOP, he is also involved in outcome research centered on patient safety in the operating room.

Ari Y. Weintraub, MD 's area of research interest is in describing and characterizing the effects of exposure to anesthesia during the critical human neurodevelopmental period (birth to 3 years of age) on neurodevelopmental and behavioral outcomes.  His primary effort is as CHOP’s PI in the PANDAS (Pediatric Anesthesia NeuroDevelopmental Assessment Study) multicenter trial comparing exposed and unexposed siblings through neurodevelopmental testing in school age and early adolescence.  He is also interested in optimal perioperative management of diabetes, congenital hyperinsulinism, and other endocrine disorders in pediatric patients.

Jeffrey M. Feldman, MD is interested in the role of technology in pediatric patient care, especially anesthesia delivery systems and mechanical ventilation. Recent projects have evaluated anesthesia ventilators and non-invasive measurement of respiratory induced blood pressure variation. Current work includes evaluating methods for obtaining intravascular access and dosing errors when using multiple infusion pumps.