Department of Anesthesiology and Critical Care

Research
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Perioperative Cardiovascular Biology

The Department of Anesthesiology and Critical Care has broad representation in NIH-funded research in Vascular Biology.

David Eckmann, PhD, MD devotes his research effort to the understanding of the mechanobiology, biorheology, and experimental and computational thrombosis and thrombolysis associated with intravascular gas embolism. Dr. Eckmann has established strong educational and investigational linkages with the Institute for Medicine and Engineering here at Penn.

David Eckmann, PhD, MD devotes his research effort as PI in three major extramurally funded areas:

1. Targeted Drug Delivery using cell culture and multiscale computational methods to exploit molecular recognition and optimize drug carrier design for endothelial binding of micro- and nano-size particles.

 




2 .Understanding the mechanobiology, biorheology, and experimental and computational thrombosis and thrombolysis associated with Intravascular Gas Embolism.

 
3. Development of Biomimetic Endothelial Surface Layer hydrogels using biological macromolecule to construct biomaterial surface coatings to improve biocompatibility of vascular implants.

David Eckmann, PhD, MD has established strong educational and investigational linkages with faculty in Departments of Mechanical Engineering and Applied Sciences, Bioengineering, Materials Science and Engineering, Hyperbaric Medicine and Pharmacology as well as through the Institute for Translational Medicine and Therapeutics and the Institute for Medicine and Engineering here at Penn.

Also studying brain blood flow is William Armstead, PhD. Dr. Armstead's research focuses on characterizing mechanisms important in the control of cerebral hemodynamics under physiologic and pathologic conditions such as traumatic brain injury (TBI), stroke, and cerebral hypoxia/ischemia, particularly in the newborn. Current projects focus on interactions between the NMDA receptor and plasminogen activators after TBI, optimizing the efficacy/toxicity ratio of tPA, the only FDA approved treatment for stroke and translational research concerning the roles of sex and age in outcome after pediatric TBI.

Several industry-supported clinical projects involving cardiovascular medicine are taking place in the department. Albert Cheung, MD and Yianni (John) Augoustides, MD use echocardiography and pharmacology to understand better the multifaceted cardiopulmonary bypass period. Stuart Weiss, MD and Albertl Cheung, MD collaborate with members of the Department of Neurology to test methods for protection of the spinal cord during abdominal aortic aneurism surgery.

As with the other research themes in the department, perioperative cardiovascular biology relies on and exploits strong collaborations with other departments, schools and institutes.