EBSDC Component 1 - Cerebral Circulatory Control

6. CEREBRAL CIRCULATORY CONTROL AND BRAIN METABOLISM (See also 3.00, 3.40)

#	Experiment Name
6.00	CEREBRAL BLOOD FLOW-GENERAL
6.10	HYPOXIA-CO2 INTERACTIONS-CBF, RESPIRATORY MINUTE VOLUME 1955-56, ABSTRACT, see figures in these references
	REPORT: Lambertsen, C.J. Effects of hyperoxia on organs and their tissues. In: Extrapulmonary Manifestations of Respiratory Disease. Robin, E., Ed. New York: Marcel Dekker, pp. 239-303, 1978.
	REPORT: Lambertsen, C.J. Chemical control of respiration at rest. In: Medical Physiology, 14th ed. Mountcastle, V.B., Ed., St. Louis: C.V. Mosby CO., pp. 1774-1827, 1980.
6.20	CBF - THIOPENTAL - HYPERVENTILATION
	REPORT: Pierce, E.C., C.J. Lambertsen, S. Deutsch, P.E. Chase, H.W. Linde, R.D. Dripps and H.L. Price. Cerebral circulation and metabolism during thiopental anesthesia and hyperventilation in man. J. Clin. Invest. 41: 1664-1671, 1962.
6.30	CEREBRAL BLOOD FLOW, SCHIZOPHRENIC PATIENTS. Secure.
6.40	BRAIN PO2 AT HIGH ALTITUDE-CO2 EFFECTS (44,000 FT)
	REPORT: Pierce, E.C., C.J. Lambertsen, M.J. Strong, S.C. Alexander and D. Steele. Blood PCO2 and brain oxygenation at reduced ambient pressure. J. Appl. Physiol. 17: 899-908, 1962.
6.60	BRAIN METABOLISM: DETAILED PROJECT DATA IN REPORTS
	REPORT: Kovachich, G.B. Inactivation by 6-hydroxydopamine of the cerebral factor(s) responsible for the inhibition of the autoxidation of norepinephrine in vitro. Neurosci. Lett. 58: 245-250, 1985.
	REPORT: Abemayer, E., G.B. Kovachich and N. Haugaard. Effects of dichloroacetate on brain pyruvate dehydrogenase. J. Neurochem. 42: 38-42, l984.
	REPORT: Kovachich, G.B. and O.P. Mishra. Stabilization of ascorbic acid and norepinephrine in vitro by the subcellular fractions of rat cerebral cortex. Neurosci. Lett. 52: 153-158, 1984.
	REPORT: Mishra, O.P. and G.B. Kovachich. Inhibition of the autoxidation of ascorbate and norepinephrine by extracts of Clostridium butyricum, Megasphera elsdenii and Escherichia coli. Life Sciences 35: 849-854, l984.
	REPORT: Mishra, O.P. and G.B. Kovachich. Inhibition of ascorbate autoxidation by a dialyzed, heat denatured extract of plant tissues. Life Sciences 34: 2207-2212, l984.
	REPORT: Kovachich, G.B., and O.P. Mishra. The effect of ascorbic acid on malonaldehyde formation, K+, Na+ and water content of brain slices. Exp. Brain Res. 50: 62-68, 1983.
	REPORT: Kovachich, G.B., and O.P. Mishra. Inhibition of norepinephrine autoxidation by a rat brain cortical factor. Neuroscience Lett. 37: 63-68, 1983.
	REPORT: Mishra, O.P. and G.B. Kovachich. Inhibition of ascorbate autoxidation by the dialyzed soluble fraction of mammalian nervous tissues. Neurosci. Lett. 43: 103-108, 1983.
	REPORT: Kovachich, G.B., and O.P. Mishra. Inhibition of ascorbate autoxidation by a rat brain cortical factor. Neurosci. Lett. 34: 83-87, 1982.
	REPORT: Kovachich, G.B., and O.P. Mishra. Partial inactivation of Na+, K-ATPase in cortical brain slices incubated in normal Krebs-Ringer phosphate medium at 1 and at 10 ATM oxygen pressures. J. Neurochem. 36: 333-335, 1981.
	REPORT: Kovachich, G.B., O.P. Mishra and J.M. Clark. Depression of cortical Na+, K+-ATPase activity in rats exposed to hyperbaric oxygen. Brain Res. 206: 229-232, 1981.
	REPORT: Kovachich, G.B. Depression of 14CO2 production from (U-14C) glucose in brain slices under high-pressure oxygen: relationship between metabolic rate and tissue sensitivity to oxygen. J. Neurochem. 34: 459-462, 1980.
	REPORT: Kovachich, G.B., and O.P. Mishra. Lipid peroxidation in rat brain cortical slices as measured by the thiobarbituric acid test. J. Neurochem. 35: 1449-1452, 1980.
	REPORT: Kovachich, G.B., and N. Haugaard. Pyruvate dehydrogenase activation in rat brain cortical slices by elevated concentrations of external potassium ions. J. Neurochem. 28: 923-927, 1977.
	REPORT: Kovachich, G.B., M.J. Schina and N. Haugaard. Inhibitory effect of high oxygen pressure on potassium-induced activation of pyruvate dehydrogenase and glucose metabolism in rat brain slices. Biochem. Biophys. Acta 462: 493-500, 1977.

08 February 2000 03:17:03 PM

For information, contact EBSDC: clambert@mail.med.upenn.edu