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PREDICTIVE STUDIES II (PS II): Normoxic Nitrogen, 4.0 ATA. 14 Days.
Major Category: Inert Gas Effects-Density / Hydrostatic Pressure / Narcosis
Subcategory: Predictive Studies II (Expt. 12.30). Prolonged exposure to normoxic nitrogen at 4.0 ATA.

Date: Summer, 1970

Expt. Title: Predictive Studies II. Chronic Nitrogen Exposure, 4 ATA.

Description:

A 14-day saturation exposure of 6 Subjects to 5.2% O2 in N2 at 4.0 ATA (100 FSW) in laboratory pressure chambers of the Institute for Environmental Medicine, University of Pennsylvania. Purpose was to perform the first study for cumulative effects or adaptation in a demonstrated narcotic, normoxic increase of atmospheric N2 pressures and density. Emphasis was given to integrated broad CNS-related studies of Performance, respiratory and cardiovascular control functions, and respiratory-pulmonary mechanical adaptation to increased work of breathing in rest and work.

Measurements:
Medical Examinations (Expt. 12.30.1)

General Medical
Auditory-Vestibular
Neurological
Ophthalmological
Radiological
Cardiac Electrical
Body Fluid
Dental
Psychological Evaluation

Pulmonary and Ventilatory Functions (Expt. 12.30.2)
    Lung Mechanics

Expiratory & Inspiratory Flow Rates
Pulmonary Resistance
Work of Breathing
Static and Dynamic Pulmonary Compliance
Esophageal Pressures

Lung Volumes

Capacities (Vital, Inspiratory, Total Lung, Functional Residual)
Expiratory Reserve Volume
Residual Volume

Lung Dynamics

Flow rates
Maximum Voluntary Ventilation

Lung Diffusion

          Diffusion Capacity for CO

Respiratory Control (N2 and He as background gases) (Expt. 12.30.3)

Respiratory Homeostasis
Rest and Exercise
Ventilation
Tidal Volume
Respiratory Frequency
End-Tidal PCO₂
Arterial Blood Gas & Acid-Base Parameters
Body Temperature
Cardiac Rate
Ventilatory Response to CO2
Tidal Volume Response to CO2
Respiratory Frequency Response to CO2

Decompression (Expt. 12.30.4)

From Nonsaturation Exposures
From Saturation Exposures

Blood and Urine Studies (Expt. 12.30.5)

Hematology
Biochemistry
Immunology
Endocrine
Body Fluid Volumes

Mental Performance (Nitrogen Narcosis) (Expt. 12.30.6) Cognitive Function

Wexler Adult Intelligence Scale
Minnesota Multiphasic Personality Inventory
Arithmetic Test
Number Comparison Test
Letterset Test
Card Rotation Test
Memory Test

Psychomotor Functions (in preparation: C.R. Coler and E.C. Lampkin)

Information Processing
Response Latency
Short Term Memory

Taste & Olfactory Sensation

Glucose
NaCl
Citric Acid
Quinine Sulfate

REPORT: Alexander, W. C., C. S. Leach, C. L. Fischer, C. J. Lambertsen, and P. C. Johnson. Hematological, biochemical, and immunological studies during a 14-day continuous exposure to 5.2% O2 in N2 at pressure equivalent to 100 FSW (4 ATA). Aerosp. Med. 44: 850-854, 1973.

REPORT: Elcombe, D. D., and J. H. Teeter. Nitrogen narcosis during a 14-day continuous exposure to 5.2% O2 in N2 at pressure equivalent to 100 FSW (4 ATA). Aerosp. Med. 44: 864-869, 1973.

REPORT: Johnson, P. C., Driscoll, T. B., W. C. Alexander, and C. J. Lambertsen. Body fluid volume changes during a 14-day continuous exposure to 5.2% O2 in N2 at pressure equivalent to 100 FSW (4 ATA). Aerosp. Med. No. 7, Sect. II. 44: 860-863, 1973.

REPORT: Lambertsen, C. J., and H. Bardin. Decompression from acute and chronic exposure to high nitrogen pressure. Aerosp. Med. 44: 834-836, 1973.

REPORT: Lambertsen, C. J., R. Gelfand, M. J. Lever, G. Bodammer, N. Takano, T. A. Reed, J. G. Dickson, and P. T. Watson. Respiration and gas exchange during a 14-day continuous exposure to 5.2% O2 in N2 at pressure equivalent to 100 FSW (4 ATA). Aerosp. Med. 44: 844-849, 1973.

REPORT: Lambertsen, C. J., and W. B. Wright. Multiday exposure to 5.2 per cent O2 at 4 ATA. Scope of program. Aerosp. Med. 44(7): 828-833, 1973.

REPORT: Leach, C. S., W. C. Alexander, C. L. Fischer, C. J. Lambertsen, and P. C. Johnson. Endocrine studies during a 14-day continuous exposure to 5.2% O2 in N2 at pressure equivalent to 100 FSW (4 ATA). Aerosp. Med. 44: 855-859, 1973.

REPORT: Wright, W. B., A. B. Fisher, P. L. Hendricks, J. S. Brody, and C. J. Lambertsen. Pulmonary function studies during a 14-day continuous exposure to 5.2% O2 in N2 at pressure equivalent to 100 FSW (4 ATA). Aerosp. Med. 44: 837-843, 1973.

07 February 2000 10:06:22 AM