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PREDICTIVE STUDIES V (PS V): Oxygen Tolerance and Toxicity.
Major Category: Pulmonary and neurologic O2 tolerance and toxicity (PS V)
Subcategory 1: Predictive Studies V (PS V). (Expt. 9.70). Rates of development of pulmonary and neurologic systems hyperoxic poisoning. Rates of recovery.

Expt. Title: Predictive Studies V. Human tolerance to continuous O2 exposure at 1.5, 2.0, 2.5, and 3.0 ATA.

Date: 1983-1987

Description: Multiple physiological functions were measured at rest before, during, and after continuous O2 breathing in a pre-planned program of hyperoxic exposures at increased ambient pressures.

Experiment protocols, measurement modules, and detailed data for each O2 pressure are available.

Experiment: Oxygen exposure.

3.0 ATA - In 1983-84, 18 Subjects were studied at 3.0 ATA. Exposures of 2 initial Subjects were stopped at 2.0 hours with no measurable effects. Exposures of 14 Subjects were continued to 3.5 hours. One exposure was stopped at 2.5 hours (syncopal episode), and another was stopped at 3.0 hours (convulsion).

2.0 ATA - In 1985, 7 Subjects were exposed at 2.0 ATA for 8.0 to 11.9 hours.

1.5 ATA - In 1985, 9 Subjects were exposed at 1.5 ATA for 16.8 to 19.0 hours. One exposure at 1.5 ATA was stopped at 3.0 hours. All but 2 of these Subjects were exposed in pairs.

2.5 ATA - In 1986, 8 Subjects were exposed at 2.5 ATA for 5.1 to 6.0 hours.

2.0 ATA - In 1987, 8 Subjects were exposed at 2.0 ATA for 5.5 to 10.0 hours.

1.0 ATA - 1983-1984. Exposures on air at 1.0 ATA for 3.5 hours were completed in 10 Subjects, 8 of whom also had 3.0 ATA O2 exposures. These were used to compare with the effects of the O2 exposures.

1.0 ATA - In 1985 five of the 1.5 ATA Subjects also completed control exposures at 1.0 ATA on air for 19.2 to 20.3 hours.

07 February 2000 10:17:25 AM