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PREDICTIVE STUDIES V (PS V): Oxygen Tolerance and Toxicity.
Major Category: Pulmonary and neurologic O2 tolerance and toxicity (PS V)
Subcategory 7: Pulmonary function. Mechanical. Gas exchange.

Expt. Title: Human tolerance to continuous O2 exposure at 1.5, 2.0, 2.5, and 3.0 ATA. Predictive Studies V (PS V). (Expt. 9.70)

Description: See PS V "Experiment protocols and measurement modules" for general description.

Measurements:

Lung volumes and flow rates (forced expiratory vital capacity, one-second forced expired volume, maximal mid-expiratory flow rate, peak expiratory flow rate, slow vital capacity, inspiratory capacity, expiratory reserve volume), density dependence of flow rates (flow difference at 50% vital capacity, lung volume at equal flow rates), closing volumes, carbon monoxide diffusing capacity, arterial blood gases (PO2, PCO2, pH, HCO₃), alveolar-arterial PO2 differences at rest and during exercise, lung compliance, airway resistance, bronchoalveolar lavage (cells, protein).

REPORT: Lambertsen, C.J., J.M. Clark, R. Gelfand, J.B. Pisarello, W.H. Cobbs, J.E. Bevilacqua, D.M. Schwartz, D.J. Montabana, C.S. Leach, P.C. Johnson, and D.E. Fletcher. Definition of tolerance to continuous hyperoxia in man. An abstract report of Predictive Studies V. In: Underwater and Hyperbaric Physiology IX. Proceedings of the Ninth International Symposium on Underwater and Hyperbaric Physiology. Edited by A.A. Bove, A.J. Bachrach, and L.J. Greenbaum. Bethesda: Undersea and Hyperbaric Medical Society, 1987. pp. 717-735.

REPORT: Clark, J.M., R. Gelfand, N.D. Flores, C.J. Lambertsen, and J.B. Pisarello. Pulmonary tolerance in man to continuous O2 exposure at 3.0, 2.5, 2.0, and 1.5 ATA in Predictive Studies V. In: Underwater and Hyperbaric Physiology IX. Proceedings of the Ninth International Symposium on Underwater and Hyperbaric Physiology. Edited by A.A. Bove, A.J. Bachrach, and L.J. Greenbaum. Bethesda: Undersea and Hyperbaric Medical Society, 1987. pp. 737-749.

REPORT: Clark, J.M. Pulmonary limits of O2 tolerance in man. Experimental Lung Research 14: 897-910, 1988.

REPORT: Lambertsen, C.J. Extension of O2 tolerance in man: Philosophy and significance. Experimental Lung Research 14: 1035-1058, 1988.

REPORT: Clark, J.M., R.M. Jackson, C.J. Lambertsen, R. Gelfand, W.D.B. Hiller, and M. Unger. Pulmonary function in men after O2 breathing at 3.0 ATA for 3.5 h. J. Appl. Physiol. 71: 878-885, 1991.

REPORT: Clark, J. M., C. J. Lambertsen, R. Gelfand, N. D. Flores, J. B. Pisarello, M. D. Rossman, and J. A. Elias. Effects of prolonged O2 exposure at 1.5, 2.0, or 2.5 ATA on pulmonary function in men (Predictive Studies V). J. Appl. Physiol. 86(1): 243-259, 1999.

REPORT: Clark, J.M., C.J. Lambertsen, J. Pisarello, R. Jackson, and R. Gelfand. Cardiopulmonary effects of continuous O2 exposure at 3.0 ATA for 3.5 hours (ABSTRACT). Undersea Biomed. Res. 11 (Supp.): 29, 1984.

REPORT: Lambertsen, C.J., J.M. Clark, R. Gelfand, J. Pisarello, R. Jackson, R. Marsh, W. Cobbs, R. Harner, J. Bevilacqua, D. Fletcher, and D. Montabana. Predictive Studies V - Tolerance of human organs and functions to continuous hyperoxia (ABSTRACT). Undersea Biomed. Res. 11 (Supp.): 34, 1984.

REPORT: Jackson, R., J.M. Clark, R. Gelfand, J. Pisarello, and C.J. Lambertsen. Effects of hyperbaric hyperoxia (3.0 ATA for 3.5 hours) on human pulmonary function (ABSTRACT). Amer. Rev. Resp. Dis. 131 (4, pt. 2): A184, 1985.

REPORT: Clark, J.M., R. Gelfand, N. Flores, J. Pisarello, and C.J. Lambertsen. Pulmonary mechanics and gas exchange in man during and after O2 exposure at 1.5 ATA for 16 to 19 hours (ABSTRACT). Amer. Rev. Resp. Dis. 133 (4, pt. 2): A31, 1986.

REPORT: Clark, J.M., R. Gelfand, N.D. Flores, J. Pisarello, and C.J. Lambertsen. Pulmonary function alterations and symptoms in man during and after O2 exposure at 2.5 ATA for 5-6 hours (ABSTRACT). Amer. Rev. Resp. Dis. 135 (4): A265, 1987.

REPORT: Clark, J.M., R. Gelfand, and C.J. Lambertsen. Unexpected magnitude and rate of decline in human pulmonary mechanical function during O2 exposure at 2.5 ATA for 5-6 hours (ABSTRACT). Aerospace Medical Association 60th Annual Scientific Meeting, 1989. p. A45.

REPORT: Clark, J.M., R. Gelfand, W.C. Stevens, and C.J. Lambertsen. Comparison of human visual and pulmonary responses to continuous and intermittent O2 exposure at 2.0 ATA in Predictive Studies V and VI (ABSTRACT). Undersea Biomed. Res. 18 (Supp.): 86, 1991.

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