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PREDICTIVE STUDIES V (PS V): Oxygen Tolerance and Toxicity.
Major Category: Pulmonary and neurologic O2 tolerance and toxicity (PS V)
Subcategory 8: Respiratory control. Chemoreflex. CO2 reactivity.

Expt. Title: Human tolerance to continuous O2 exposure at 1.5, 2.0, 2.5, and 3.0 ATA. Predictive Studies V (PS V). (Expt. 9.70)

Date: 1983-1987

Description: See "Experiment protocols and measurement modules" for general description.

Measurements:

    Ventilatory response to hypercapnia, ventilatory response to hypoxia, inspiratory duration, expiratory duration.

REPORT: Lambertsen, C.J., J.M. Clark, R. Gelfand, J.B. Pisarello, W.H. Cobbs, J.E. Bevilacqua, D.M. Schwartz, D.J. Montabana, C.S. Leach, P.C. Johnson, and D.E. Fletcher. Definition of tolerance to continuous hyperoxia in man. An abstract report of Predictive Studies V. In: Underwater and Hyperbaric Physiology IX. Proceedings of the Ninth International Symposium on Underwater and Hyperbaric Physiology. Edited by A.A. Bove, A.J. Bachrach, and L.J. Greenbaum. Bethesda: Undersea and Hyperbaric Medical Society, 1987. pp. 717-735.

REPORT: Gelfand, R., J.M. Clark, C.J. Lambertsen, and J.B. Pisarello. Effects on respiratory homeostasis of prolonged continuous hyperoxia at 1.5 to 3.0 ATA in man in Predictive Studies V. In: Underwater and Hyperbaric Physiology IX. Proceedings of the Ninth International Symposium on Underwater and Hyperbaric Physiology. Edited by A.A. Bove, A.J. Bachrach, and L.J. Greenbaum. Bethesda: Undersea and Hyperbaric Medical Society, 1987. pp. 751-761.

REPORT: Lambertsen, C.J. Extension of O2 tolerance in man: Philosophy and significance. Experimental Lung Research 14: 1035-1058, 1988.

REPORT: Lambertsen, C.J., J.M. Clark, R. Gelfand, J. Pisarello, R. Jackson, R. Marsh, W. Cobbs, R. Harner, J. Bevilacqua, D. Fletcher, and D. Montabana. Predictive Studies V - Tolerance of human organs and functions to continuous hyperoxia (ABSTRACT). Undersea Biomed. Res. 11 (Supp.): 34, 1984.

REPORT: Gelfand, R., J.M. Clark, C.J. Lambertsen, and J. Pisarello. Ventilatory response to hypoxia following prolonged hyperoxia at 1.5 ATA in man (ABSTRACT). Fed. Proc. 46 (3): 827, 1987.

REPORT: Gelfand, R., J.M. Clark, C.J. Lambertsen, and J.B. Pisarello. Ventilatory response to CO2 following prolonged hyperoxia at 1.5 ATA and 2.5 ATA in man. FASEB J. 2(5): A1508, 1988.

REPORT: Gelfand, R., J.M. Clark, C.J. Lambertsen, and J.B. Pisarello. Ventilatory response to hypoxia following prolonged hyperoxia at 2.5 ATA in man in Predictive Studies V. Undersea Biomed. Res. 15 (Supp.): 34-35, 1988.

REPORT: Gelfand, R., J.M. Clark, and C.J. Lambertsen. Respiratory control timing characteristics during prolonged hyperoxia at 1.5, 2.0, 2.5, and 3.0 ATA (Predictive Studies V). Undersea Biomed. Res. 16 (Supp.): 93-94, 1989.

REPORT: Gelfand, R., J.M. Clark, and C.J. Lambertsen. Ventilatory response to hypoxia is preserved following prolonged hyperbaric hyperoxia at 1.5, 2.0, and 2.5 ATA in man (Predictive Studies V). Undersea Biomed. Res. 17 (Supp.): 163, 1990.

REPORT: Gelfand, R., J.M. Clark, and C.J. Lambertsen. Ventilatory response to carbon dioxide is not diminished after human exposure to prolonged hyperbaric hyperoxia at 1.5, 2.0, and 2.5 ATA (Predictive Studies V). Undersea Biomed. Res. 18 (Supp.): 87, 1991.

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