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PREDICTIVE STUDIES VII (PS VII): Interactions of Hyperoxia, Exercise, and Immersion in Neurologic O2 Poisoning.
Major Category: Oxygen toxicity and oxygenation. Immersion. Exercise. (PS VII)
Subcategory 2: Methods: Calibration of middle cerebral artery blood flow velocity by Transcranial Doppler vs ¹³³Xe brain blood flow over wide P_aCO2 range.

Stressors: CO2, voluntary hyperventilation

Date: 1992

Expt. Title: Establishment of on-line method for quantitative indirect measurement of brain blood flow (Expt. 13.00)

Description:

See PS VII protocols. Reports. Simultaneous measurement in 8 Subjects at rest of middle cerebral artery blood flow velocity (McAvel) and brain blood flow by clearance of radioactive xenon, over an arterial PCO2 range of 25 to 50 mm Hg while breathing O2 at 1.0 ATA.

Measurements:

MCA blood flow velocity, brain blood flow (CBF₁₅, ISI, regional, global), arterial and end-tidal PCO2, arterial PO2 and pH, heart rate, systolic and diastolic blood pressures.

REPORT: Clark, J. M., B. E. Skolnick, R. Gelfand, R. E. Farber, M. Stierheim, W. C. Stevens, G. Beck, Jr., and C. J. Lambertsen. Relationship of ¹³³Xe cerebral blood flow to middle cerebral arterial flow velocity in men at rest. J. Cerebral Blood Flow Metab. 16: 1255-1262, 1996.

REPORT: Clark, J.M., B.E. Skolnick, R. Gelfand, R.E. Farber, M. Stierheim, W.C. Stevens, G. Beck, Jr., and C.J. Lambertsen. Correlation of middle cerebral artery blood flow velocities with ¹³³Xe cerebral blood perfusion rates during O2 breathing in man over a wide range of arterial PCO2 values. Undersea and Hyperbaric Med. 20(Supp.): 12, 1993.

REPORT: Stevens, W.C., J.M. Clark, R. Gelfand, G. Beck, M. Stierheim, R.E. Farber, and C.J. Lambertsen. Relationships of brain blood velocity to arterial PCO2 at rest and during exercise (ABSTRACTS). Med. Sci. Sports Exer. 25(5): S55, 1993.

REPORT: Farber, R. E., J. M. Clark, B. Skolnick, R. Gelfand, M. Stierheim, G. Beck, W. C. Stevens, and C. J. Lambertsen. Transcranial Doppler (TCD) flow monitoring at varying levels of CO2: Direct correlation with xenon blood flow over a wide range of PCO2 values (ABSTRACT). Neurology 43(4): A342, 1993.

07 February 2000 11:06:45 AM