Emergency Medicine

Toxicology Research

The Toxicology Division has published many observational and descriptive studies on emerging trends and complications of drug abuse in urban populations. Most recently, the focus has been geared toward the implications and factors contributing to the expanding prescription drug epidemic and assessing and measuring factors aimed at mitigating morbidity. Students and residents are engaged in ongoing projects.

Selected Publications

Jang DH, Lampe J, Becker LB. The Potential Application of Mitochondrial Medicine in Toxicologic Poisoning. J Med Toxicol. 2015 Jun;11(2):201-7. PMID: 25907836.

Jang DH, Shofer FS, Weiss SL, et al. Impairment of Mitochondrial Respiration Following Ex-vivo Cyanide Exposure in Peripheral Blood Mononuclear Cells. Clin Tox. 2016 Feb 5:1-5. 26846815.

Jang DH, Greenwood J, Spyres MB, Eckmann DM. Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma and poisoning. Journal of Intensive Critical Care. In Press.

Jang DH, Spyres MD, Valente A, et al. Mitochondrial Inhibitors and Alteration in Bioenergetics-The Dose makes the Poison. Journal of Forensic Toxicology and Pharmacology. 2016. Accepted for publication.

Gugelmann HM Perrone J: Can prescription drug monitoring programs help limit opioid abuse? JAMA 306(20): 2258-9, Nov 2011.

Mazer M, Deroos F, Hollander JE, McCusker C, Peacock N, Perrone J: Medication history taking in emergency department triage is inaccurate and incomplete. Academic Emergency Medicine 18(1): 102-4, Jan 2011.

Mazer M, DeRoos F, Shofer F, Hollander J, McCusker C, Peacock N, Perrone J: Medications from the Web: Use of Online Pharmacies by Emergency Department Patients. The Journal of Emergency Medicine 42(2): 227-32. February 2012.

Perrone J, Nelson LS: Medication Reconciliation for Controlled Substances-An Ideal Prescription-Drug Monitoring Program. New England Journal of Medicine 10, June 2012.

Friend K, Milone MC, Perrone J: Hyponatremia Associated With Levamisole-Adulterated Cocaine Use in Emergency Department Patients. Annals of Emergency Medicine 60(1): 94-96. July 2012.

Nelson LS, Perrone J.: Curbing the opioid epidemic in the United States: the Risk Evaluation and Mitigation Strategy (REMS). JAMA 308: 457-8, August 2012.

Perrone J, DeRoos FJ, Nelson LS: Prescribing practices, knowledge, and use of Prescription Drug Monitoring Programs (PDMP) by a national sample of medical toxicologists, 2012. Journal of Medical Toxicology 8: 341-352, Dec 2012.

Wightman R, Perrone J, Portelli I, Nelson L: Likeability and Abuse Liability of Commonly Prescribed Opioids. Journal of Medical Toxicology 8(4): 335-340, Dec 2012.

Davis GG, Nelson LS, Aiken SS, Druid H, Gill JR, Goldberger BA, Melinek J, Middleberg RA, Middleton OL, Perrone J, Wax PM, Nolte KB. : National Association of Medical Examiners and American College of Medical Toxicology Expert Panel on Evaluating and Reporting Opioid Deaths. National Association of Medical Examiners Position Paper: Recommendations for the Investigation, Diagnosis, and Certification of Deaths Related to Opioid Drugs. Acad Forensic Pathol 3: 77-83, March 2013.

Gugelmann HM, Shofer FS, Meisel ZF, Perrone J: Multidisciplinary intervention decreases the use of opioid medication discharge packs from two urban emergency departments. American Journal of Emergency Medicine 31(9): 1343-8, July 2013.

Lapoint J, Perrone J, Nelson LS: Electronic Pharmacopoeia: A Missed Opportunity for Safe Opioid Prescribing Information? J Med Toxicol. 2013 Oct 1. October 2013.

Kilaru A, Perrone J, Barq F, Meisel Z: Narratives Outperform Summary Content in Promoting Recall of Opioid Prescription Guideline Recommendations. Academic Emergency Medicine May 2013.

Shutler L, Portelli I, Perrone J, Blanchford CR, Nelson LS: Prescription Opioids in the Twittersphere: A Contextual Analysis of Tweets About Prescription Drugs. American College of Emergency Physicians Annual Scientific Meeting Research Forum, Seattle Washington October 2013.

Gugelmann HM, Perrone J, Nelson LS: Windmills and Pill Mills: Can PDMPs Tilt the Prescription Drug Epidemic? Journal of Medical Toxicology 8: 378-386, Dec 2012.

Johnson NJ, Gaieski DF, Allen SR, Perrone J, DeRoos F: A review of emergency cardiopulmonary bypass for severe poisoning. Journal of Medical Toxicology; accepted December 2012 2012.

Weiner S, Perrone J, Nelson LS: Centering the Pendulum: The Evolution of Emergency Medicine Opioid Prescribing Guidelines. Annals of Emergency Medicine in press, April 2013.

Harvey V, Kim P, Perrone J: Does the Use of Tranexamic Acid Improve Trauma Mortality? Annals of Emergency Medicine November, 2013.

Nelson LS, Loh M, Perrone J.: Assuring Safety of Inherently Unsafe Medications: the FDA Risk Evaluation and Mitigation Strategies. J Med Toxicol, January 2014.

 

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