Emergency Medicine

Emergency Ultrasound Research - Grants

Grant Funded Research

Randomized Control Trial of Ultrasound Guided IV Access Versus Intraosseous Access in Stable Difficult Access Patients.
Date: 07/01/13 – current
Funding: EMF
Summary: This is a randomized control trial of stable difficult access patients comparing ultrasound guided IV access versus intraosseous access.  Outcome measures include achievement of successful access, time to access, time to therapy, complications, patient satisfaction and physician satisfaction.  Additionally, a novel sub-study within this grant is a patient centered assessment of how media, text versus video, affects patient’s understanding of procedures and their preference for ultrasound guided IV versus intraosseous access.
Role: PI – Nova Panebianco, Co-Investigator – Anthony Dean

Study of Tomography of Nephrolithiasis Evaluation (“STONE”)
Date:  01/01/12 – 09/29/13
Funding: NIH - AHRQ
Summary: This project was a randomized control trial of patients presenting to the ED with signs or symptoms of acute nephrolithiasis.  Patients were randomized into abdominal CT, radiology ultrasound or ED bedside ultrasound.  This study aimed to compare several measures of effectiveness including a) morbidity related to patient’s underlying disease or complications related to delayed diagnosis, b) patient functional status c) utilization of health care resources based on patient’s randomization to one of the three study arms.  Additionally, the study aimed to compare measures of safety including cumulative radiation exposure, and lifetime attributable risk of cancer from medical imaging radiation.  Comparisons of cost and accuracy of each of the imaging modalities was also compared.
Role: Site PI – Anthony Dean, Co-Investigator – Nova Panebianco 

Risk Factors as Predictors of Ectopic Pregnancy
Date: 07/01/06-06/30/11
Funding: NIH
Summary:  This study  prospectively enrolled patients presenting to the emergency department with symptoms of ectopic pregnancy (a positive pregnancy test and abdominal pain and/or vaginal bleeding).  In addition to the usual ED management of such patients (pelvic ultrasound and blood tests as indicated), serum markers were  obtained and analyzed for significant association with the presence or absence of ectopic pregnancy as well as with abnormal intrauterine gestation. 
Role: Co-Investigator – Anthony Dean

Randomized clinical trial on management of early pregnancy failure
Date: 4/01/00-04/31/04
Funding: NIH
Summary: RCT of patients with pregnancy loss before 13 weeks gestation (including ectopic pregnancy, spontaneous, incomplete, and inevitable abortion) randomized to receive either out-patient medical management with intravaginal misoprostyl or routine operative management.  The 2 arms were compared for outcomes including resolution of symptoms, complications and days of hospitalization.
Role: Co-Investigator – Anthony Dean

Perfusion by Thrombolytic and Ultrasound.
Date: 2002-2003
Funding: Industry 
A randomized multicenter trial of transcutaneous, low-energy ultrasound therapy with thrombolysis for patients with acute myocardial infarction.         
Summary: Patients with ST-elevation MI were randomized to receive thrombolysis with or without the adjunctive application of transcutaneous, low-energy ultrasound therapy.  Outcomes were analyzed  to assess for evidence of revascularization as well as the composite end-points of death, stroke, hemorrhage or myocardial infarction. 
Role: Subinvestigator – Anthony Dean