University
of Pennsylvania
Division of Endocrinology,
Diabetes, & Metabolism
415 Curie Blvd., 752b CRB
Philadelphia, PA 19104-6149
Phone: (215) 898-4425
Fax: (215) 573-5809
E-mail: necooke@mail.med.upenn.edu
Education
Undergraduate:
Case Western Reserve University
Cleveland, Ohio
Degree: B.S.
Medical: Case Western Reserve University School of Medicine
Cleveland, Ohio
Degree: M.D.
Residency
Barnes
Hospital
St. Louis, Missouri
Fellowship:
Washington University School of Medicine
St. Louis, Missouri
Board Certification:
Internal Medicine
Biography
Nancy
E. Cooke, M.D. is a Professor of Medicine in the Division
of Endocrinology, Diabetes, and Metabolism at the
University of Pennsylvania. Dr. Cooke received her
B.S. in Chemistry from Wellesley College and Case
Western Reserve University, and her M.D. from Case
Western Reserve University School of Medicine. Before
coming to Penn she was a resident in Medicine at Barnes
Hospital, Washington University; a Clinical Fellow
in Endocrinology and Metabolism at Washington University
School of Medicine; a Research Associate in the Howard
Hughes Medical Institute, Department of Biochemistry,
University of California San Francisco, and an Assistant
Professor in the Department of Medicine, University
of California San Francisco. Dr. Cooke has been a
member of the Penn faculty since 1982. She is a member
of the American Society for Clinical Investigation,
the American Association of Physicians, and the Interurban
Clinical Club. She has served as Councilor of the
Endocrine Society and on several NIH review panels.
She founded and directs the Transgenic & Chimeric
Mouse Facility of the University of Pennsylvania.
Research in Dr. Cooke’s laboratory focuses on
molecular endocrinology. Specifically her lab studies
the mechanisms involved in the regulation of growth
hormone gene expression. This includes the effect
of changes in the large chromatin domain surrounding
the growth hormone family of genes caused by activation
of its distal regulatory element, the locus control
region (LCR). Studies also focus on the expression
of the B-lymphocyte immunoglobulin receptor, Igb,
located within the growth hormone chromatin domain,
in both normal lymphocytes and during the development
of chronic lymphocytic leukemia (CLL), as well as
the expression of the related chorionic somatomammotropin
and growth hormone-variant genes expressed in the
placenta during pregnancy. A second area of research
concerns the vitamin D binding protein (DBP). Its
expression and its functions in bone and mineral metabolism
are being studied in transgenic and DBP null mouse
models.
