University
of Pennsylvania
Division of Endocrinology,
Diabetes, & Metabolism
415 Curie Blvd., 752b CRB
Philadelphia, PA 19104-6149
Phone: (215) 898-4425
Fax: (215) 573-5809
E-mail: necooke@mail.med.upenn.edu
Education
Undergraduate:
Case Western Reserve University
Cleveland, Ohio
Degree: B.S.
Medical: Case Western Reserve University School of Medicine
Cleveland, Ohio
Degree: M.D.
Residency
Barnes
Hospital
St. Louis, Missouri
Fellowship:
Washington University School of Medicine
St. Louis, Missouri
Board Certification:
Internal Medicine
Biography
Nancy E. Cooke, M.D. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism at the University of Pennsylvania. Dr. Cooke received her B.S. in Chemistry from Wellesley College and Case Western Reserve University, and her M.D. from Case Western Reserve University School of Medicine. Before coming to Penn she was a resident in Medicine at Barnes Hospital, Washington University; a Clinical Fellow in Endocrinology and Metabolism at Washington University School of Medicine; a Research Associate in the Howard Hughes Medical Institute, Department of Biochemistry, University of California San Francisco, and an Assistant Professor in the Department of Medicine, University of California San Francisco. Dr. Cooke has been a member of the Penn faculty since 1982. She is a member of the American Society for Clinical Investigation, the American Association of Physicians, and the Interurban Clinical Club. She has served as Councilor of the Endocrine Society and as a member of two NIH review panels. She founded and directs the Transgenic & Chimeric Mouse Core Facility of the University of Pennsylvania.
Research in Dr. Cooke's laboratory focuses on molecular endocrinology. Specifically her lab studies the mechanisms involved in the regulation of growth hormone gene expression. This includes the effect of changes in the large chromatin domain surrounding the growth hormone family of genes caused by activation of its distal regulatory element, the locus control region (LCR). Studies also focus on the expression of the B-lymphocyte immunoglobulin receptor, Ig?, located within the growth hormone chromatin domain, in both normal lymphocytes and during the development of chronic lymphocytic leukemia (CLL), as well as the expression of the related chorionic somatomammotropin and growth hormone-variant genes expressed in the placenta during pregnancy.
